2003
DOI: 10.1530/eje.0.1490397
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Stimulating effect of growth hormone on cytokine release in children

Abstract: Objective: The aim of the present study was to investigate the effect of exogenously administered GH on serum levels of interleukin (IL)-1b, IL-2, IL-12, tumor necrosis factor (TNF)-a and interferon (IFN)-g and their relation with IGF-I levels in normal short stature children. Design and methods: 23 short prepubertal non GH-deficient children (10 females and 13 males) whose mean^S.D. chronological age was 11.95^1.85 years (from 8.80 to 14.89 years), and mean^S.D. bone age was 10.48^2.44 years, were evaluated d… Show more

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Cited by 32 publications
(27 citation statements)
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“…Our results suggest that GH administration has a deep impact on cytokine synthesis in children with complete or partial GH deficiency. The increase in TNF-a levels confirmed our previous findings that demonstrated high cytokine levels 6 h after hGH injection in GHD children (5) and after the 4th hGH injection in short non-GHD children (6).…”
Section: Discussionsupporting
confidence: 91%
See 1 more Smart Citation
“…Our results suggest that GH administration has a deep impact on cytokine synthesis in children with complete or partial GH deficiency. The increase in TNF-a levels confirmed our previous findings that demonstrated high cytokine levels 6 h after hGH injection in GHD children (5) and after the 4th hGH injection in short non-GHD children (6).…”
Section: Discussionsupporting
confidence: 91%
“…However, supporting the effect of GH on immune cells, the release of interleukin (IL)-1b and tumour necrosis factor-a (TNF-a) is increased in response to an acute GH administration in GHD children (5). Furthermore, cytokine release can be affected by short-term human GH (hGH) administration in short non-GHD children indicating a direct effect of GH on the immune function (6). The aim of the present study was to evaluate the effect of short-and long-term hGH administration on in vivo production of a large body of cytokines, by monitoring serum IL-4, IL-6, IL-12 and TNF-a concentrations in GHD children, before and during hGH treatment.…”
Section: Introductionmentioning
confidence: 99%
“…These findings suggest a role for GH in priming macrophages for TNF α synthesis [3]. Similarly, studies conducted in both normal statured and GH deficient children have illustrated significant increases in cytokine release, specifically TNF α, after short term GH administration [5] [6].…”
Section: Introductionmentioning
confidence: 89%
“…GH has been found to stimulate TNF α release in adults and children [5] [6]; however, there has been inconsistent documentation within the literature [7]- [9]. Research in hypophysectomized rats demonstrate a significant reduction in in vitro macrophage production of TNF α after stimulation with lipopolysaccharide [3].…”
Section: Introductionmentioning
confidence: 99%
“…Although GH interacts with the immune system [1,2,3], recent analysis of a large database of GH-treated patients indicates no immunological anomalies attributable to GH treatment [4]. However, it was important during clinical trials to determine if GH therapy had any impact on the progression of JIA.…”
Section: Influence Of Gh Therapy On the Course Of Jiamentioning
confidence: 99%