2020
DOI: 10.3389/fcell.2020.00445
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Stimulating Factors and Origins of Precursor Cells in Traumatic Heterotopic Ossification Around the Temporomandibular Joint in Mice

Abstract: The contributing factors and the origins of precursor cells in traumatic heterotopic ossification around the temporomandibular joint (THO-TMJ), which causes obvious restriction of mouth opening and maxillofacial malformation, remain unclear. In this study, our findings demonstrated that injured chondrocytes in the condylar cartilage, but not osteoblasts in the injured subchondral bone, played definite roles in the development of THO-TMJ in mice. Injured condylar chondrocytes without articular disc reserves mig… Show more

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Cited by 5 publications
(3 citation statements)
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References 39 publications
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“…M2M and TGF-β were reported to be capable of preventing tissue damage and stimulating differentiation of MSCs into osteoblasts and cartilage. 32,37,38…”
Section: Bone Protection By Man-pmtx In Ra Micementioning
confidence: 99%
“…M2M and TGF-β were reported to be capable of preventing tissue damage and stimulating differentiation of MSCs into osteoblasts and cartilage. 32,37,38…”
Section: Bone Protection By Man-pmtx In Ra Micementioning
confidence: 99%
“…The typical clinical features of HO include the limited range of motion around the involved joint, complete bony ankylosis in severe cases, and deformity in the cervical spine, elbow, shoulder, fingers, jaw exostosis, or temporomandibular joint ankylosis (TMJA) ( Zhao et al, 2020 ). HO could occur almost anywhere in the body, as long as it is associated with the periosteum.…”
Section: Clinical Features Of Heterotopic Ossificationmentioning
confidence: 99%
“…It is known as a complication of trauma, surgery, blast, spinal cord injury, and other stress damages ( Shimono et al, 2011 ; Regard et al, 2013 ; Ranganathan et al, 2015 ). HO clinical features include limited motion range around the involved joint; bony ankylosis in severe cases; deformity in the cervical spine, elbow, shoulder, and fingers, jaw exostosis; and temporomandibular joint ankylosis ( Zhao et al, 2020 ).…”
Section: Introductionmentioning
confidence: 99%