Stimulation and analysis of the immune response in calves from vaccinated pregnant cows

Abstract

The effect of vaccinating pregnant cows with an inactivated vaccine against Mannheimia haemolytica, BRSV and PI3V infections on selected immune responses in their offspring was examined. Blood samples were collected weekly for 12 weeks from six newborn calves from each of vaccinated (experimental) and unvaccinated (control) dams. Specific antibodies to M. haemolytica, BRSV and PI3V and mean values of IgA, IgG concentrations were significantly higher in the experimental calves compared with the controls. However, specific antibody titres to adenovirus type 3, BHV1 and BVDV in the experimental calves had constant levels while the control group levels changed. The IgM, Hp and SAA concentrations generally increased until week 8 in the experimental group, but the control group titres became higher after week 9. This study demonstrates that specific immunisation of cows pre-partum significantly stimulated parameters associated with immunity and it also controlled the acute phase response intensity in their offspring. Therefore the vaccination of dams may provide additional antibody protection against infection to their offspring.

Evaluation of Passive Immunity Induced by Immunisation Using Two Inactivated gE-deleted Marker Vaccines against Infectious Bovine Rhinotracheitis (IBR) in Calves

“…Significantly (P = 0.0021; P = 0.0013) elevated titres were also observed at PVD120. These findings are in agreement with those of other studies in which an increased colostral antibody production against BoHV-1 and various pathogens were detected after the vaccination of pregnant cattle during the pre-partum period [13,21,22,27]. In contrast, in a study conducted by Lemaire et al, a low level of antibodies against BoHV-1 was observed in two cows after two vaccinations with inactivated gE-deleted marker vaccines [28].…”

Influência da vacinação materna na transferência de imunidade passiva contra as viroses respiratórias dos bovinos

“…O bezerro VAC 10 manifestou infecção natural ao BPI3-V entre o D10 e o D15 (Martin e Bohac, 1986). Dudek et al (2014) encontraram maiores concentrações de ACs séricos contra o BRSV e o BPI3-V em filhos de vacas vacinadas no período pré-parto, porém estes autores detectaram os ACs séricos pelo teste imunoenzimático indireto, que geralmente é mais sensível que a VN (Brodersen, 2010;Ellis, 2010). Em geral, os bezerros apresentaram perfil sorológico semelhante às suas mães.…”

Effect of suckler cow vaccination against glycoprotein E (gE)-negative bovine herpesvirus type 1 (BoHV-1) on passive immunity and physiological response to subsequent bovine respiratory disease vaccination of their progeny

“…BoHV-1 virus causes respiratory infections and abortions in cattle, and is an important component of the bovine respiratory disease complex, which causes a considerable economic loss worldwide (Chowdhury, Wei, Weiss, Pannhorst, and Paulsen, 2016). Pre-partum vaccination programs have been reported to increase colostral antibodies and protect newborn calves from viruses associated with calf pneumonia, for example, Mannheimia haemolytica, BRSV, and PI3V (Makoschey, Ramage, Reddick, Fraser, and Donachie, 2012;Dudek, Bednarek, Ayling, and Szacawa, 2014). M. haemolytica is a primary bacterial pathogen associated with BRD (Reddy et al, 2012).…”