Stimulation and recording of neural tissue, closing the loop on the artifact

Brown, E.A.; Ross, Jonathan; Blum, R.A.; DeWeerth, Stephen P.

doi:10.1109/iscas.2008.4541428

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…One of the main barriers to overcome in the quest to better understand DBS and the functioning of the basal ganglia is the large stimulus artefact that tends to mask the immediate response of neural tissue to stimulation. The artefact in neural recordings is mainly due to accumulated charge in the electrode-tissue interface and usually takes the shape of a large decaying exponential that lasts several milliseconds [10]. The problem of artefact has only recently been overcome thanks to new custom-built stimulator/recording devices but very few are capable of accurately measuring responses less than 1 ms after the stimulus onset.…”

Section: Introductionmentioning

confidence: 99%

A new biomarker for subthalamic deep brain stimulation for patients with advanced Parkinson’s disease—a pilot study

et al. 2015

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Section: Introductionmentioning

confidence: 99%

A new biomarker for subthalamic deep brain stimulation for patients with advanced Parkinson’s disease—a pilot study

et al. 2015

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“…In this method, anodic-first biphasic stimulation pulses are followed by cathodic-first biphasic ones, or vice-versa. Active discharge through a transconductance driver with custom feedback of residual voltage is reported for reduced artifact time within 3 ms [1], [12], [13]. Temporary disconnection of recording path or amplifier blanking technique is a popular method to reduce stimulus artifacts [14], [15].…”

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confidence: 99%

Sensing of Stimulus Artifact Suppressed Signals From Electrode Interfaces

et al. 2015

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Stimulus artifacts inhibit reliable acquisition of biological evoked potentials for several milliseconds if an electrode contact is utilized for both electrical stimulation and recording purposes. This hinders the measurement of evoked short-latency biological responses, which is otherwise elicited by stimulation in implantable prosthetic devices. We present an improved stimulus artifact suppression scheme using two electrode simultaneous stimulation and differential readout using high-gain amplifiers. Substantial reduction of artifact duration has been shown possible through the common-mode rejection property of an instrumentation amplifier for electrode interfaces. The performance of this method depends on good matching of electrode-electrolyte interface properties of the chosen electrode pair. A novel calibration algorithm has been developed that helps in artificial matching of impedance and thereby achieves the required performance in artifact suppression. Stimulus artifact duration has been reduced down to 50 µs from the stimulationcum-recording electrodes, which is ∼6× improvement over the present state of the art. The system is characterized with emulated resistor-capacitor loads and a variety of in-vitro metal electrodes dipped in saline environment. The proposed method is going to be useful for closed-loop electrical stimulation and recording studies, such as bidirectional neural prosthesis of retina, cochlea, brain, and spinal cord.Index Terms-Stimulus artifact suppression, biphasic constant current stimulator, electrode-electrolyte interface, instrumentation and differential amplifier.

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Stimulation and recording of neural tissue, closing the loop on the artifact

Cited by 2 publications

References 17 publications

A new biomarker for subthalamic deep brain stimulation for patients with advanced Parkinson’s disease—a pilot study

A new biomarker for subthalamic deep brain stimulation for patients with advanced Parkinson’s disease—a pilot study

Sensing of Stimulus Artifact Suppressed Signals From Electrode Interfaces

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