Stimulation and transient inactivation of ventral tegmental area modify reinstatement of acquisition phase of morphine-induced conditioned place preference in male rats

Alaei, Hojjatollah; Pour, Mozhgan Ghobadi

doi:10.1016/j.brainresbull.2021.08.014

Cited by 5 publications

(10 citation statements)

References 38 publications

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“…Our laboratory investigated several current intensities for reducing addiction in animal models ( 24 30 33 ), and the intensity of the current used in this study was determined according to a similar methodology used by Alaei et al . ( 26 ). Alaei’s study showed that the e-stim of VTA by the intensity of the current of 150 μA could suppress morphine-induced CPP in male rats ( 26 ).…”

Section: Methodsmentioning

confidence: 99%

“…( 26 ). Alaei’s study showed that the e-stim of VTA by the intensity of the current of 150 μA could suppress morphine-induced CPP in male rats ( 26 ).…”

Section: Methodsmentioning

confidence: 99%

“…In addition, it was connected to the back of chambers A and B by a guillotine door. When all guillotine doors were removed, the animal could freely move between chambers A and B through chamber C 26 ).…”

Section: Methodsmentioning

confidence: 99%

“…Deep brain stimulation (DBS) is used for understanding brain function in animal models of addiction ( 15 24 ). Some animal studies have revealed that the e-stim of various brain nuclei such as NAc ( 25 ), VTA ( 26 ), and BLA ( 27 ) with high intensity could decrease drug-seeking behavior, suppress morphine-induced CPP, and reduce addiction. The mechanism of DBS activity is partially understood.…”

Section: Introductionmentioning

confidence: 99%

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The electrical stimulation of the central nucleus of the amygdala in combination with dopamine receptor antagonist reduces the acquisition phase of morphine-induced conditioned place preference in male rat

Jokar

Khatamsaz

Alaei

et al. 2023

Research in Pharmaceutical Sciences

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Background and purpose: The central nucleus of the amygdala (CeA) is one of the nuclei involved in the reward system. The aim of the current study was to investigate the electrical stimulation (e-stim) effect of the CeA in combination with dopamine D1 receptor antagonist on morphine-induced conditioned place preference (CPP) in male rats. Experimental approach: A 5-day procedure of CPP was used in this study. Morphine was administered at an effective dose of 5 mg/kg, and SCH23390 as a selective D1 receptor antagonist was administrated into the CeA. In addition, the CeA was stimulated with an intensity of the current of 150 μA. Finally, the dependence on morphine was evaluated in all experimental groups. Findings /Results: Morphine significantly increased CPP. While the blockade of the D1 receptor of the CeA reduced the acquisition phase of morphine-induced CPP. Moreover, the combination of D1 receptor antagonist and e-stim suppressed morphine-induced CPP, even it induced an aversion. Conclusion and implication: The current study suggests that the administration of dopamine D1 receptor antagonist into the CeA in combination with e-stim could play a prominent role in morphine dependence.

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Section: Methodsmentioning

confidence: 99%

“…( 26 ). Alaei’s study showed that the e-stim of VTA by the intensity of the current of 150 μA could suppress morphine-induced CPP in male rats ( 26 ).…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The electrical stimulation of the central nucleus of the amygdala in combination with dopamine receptor antagonist reduces the acquisition phase of morphine-induced conditioned place preference in male rat

Jokar

Khatamsaz

Alaei

et al. 2023

Research in Pharmaceutical Sciences

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“…A rostral-caudal incision was made to expose the skull and, the three-dimensional stereotaxic coordinates for the VTA were determined according to the Paxinos and Watson atlas: the incisor bar -3.3 mm, -5.8 mm posterior to the bregma, ±0.8 mm lateral to the sagittal suture, and -9.3 mm down from the top of the skull ( 22 ). Two 23-gauge stainless steel guide cannulas were bilaterally implanted in each rat for microinjection ( 23 ). The cannulas were secured with dental cement and affixed to two stainless steel jewelers' screws fastened to the exposed skull.…”

Section: Methodsmentioning

confidence: 99%

The reinstatement of the expression phase of morphine-induced conditioned place preference in male Wistar rats under ventral tegmental area stimulation and brief inactivation

Pour,

Alaei

2023

Research in Pharmaceutical Sciences

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Background and purpose: Previous research has found that the electrical stimulation of the ventral tegmental area (VTA) is involved in drug-dependent behaviors and plays a role in reward-seeking. However, the mechanisms remain unknown, especially the effect of electrical stimulation on this area. Therefore, this study aimed to investigate how the electrical stimulation and the temporary inactivation of VTA affect the morphine- dependent behavior in male rats. Experimental approach: The adult Wistar male rats were anesthetized with ketamine and xylazine. The stimulation electrode (unilaterally) and the microinjection cannula (bilaterally) were implanted into the VTA, stereotaxically. Then, the rats underwent three-day of repeated conditioning with subcutaneous morphine (0.5 or 5 mg/kg) injections, in the conditioned place preference apparatus, followed by four-day forced abstinence, which altered their conditioning response to a morphine (0.5 mg/kg) priming dose on the ninth day. On that day, rats were given high- or low-intensity electrical stimulation or reversible inactivation with lidocaine (0.5 pL/site) in the VTA. Findings/Results: Results showed that the electrical stimulation of the VTA with the high intensity (150 μA/rat), had a minimal effect on the expression of morphine-induced place conditioning in rats treated with a high dose (5 mg/kg) of morphine. However, the reversible inactivation of the VTA with lidocaine greatly increased place preference in rats treated with a low dose (0.5 mg/kg) of morphine. Additionally, the reinstatement of 0.5 mg/kg morphine-treated rats was observed after lidocaine infusion into the VTA. Conclusion and implications: These results suggest that VTA electrical stimulation suppresses neuronal activation, but the priming dose causes reinstatement. The VTA may be a potential target for deep brain stimulation-based treatment of intractable disorders induced by substance abuse.

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Deep brain stimulation of the lateral hypothalamus to block morphine reward: Does the intensity of stimulation matter?

Nikbakhtzadeh

Ashabi²,

Keshavarz³

et al. 2023

Behavioural Brain Research

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Stimulation and transient inactivation of ventral tegmental area modify reinstatement of acquisition phase of morphine-induced conditioned place preference in male rats

Cited by 5 publications

References 38 publications

The electrical stimulation of the central nucleus of the amygdala in combination with dopamine receptor antagonist reduces the acquisition phase of morphine-induced conditioned place preference in male rat

The electrical stimulation of the central nucleus of the amygdala in combination with dopamine receptor antagonist reduces the acquisition phase of morphine-induced conditioned place preference in male rat

The reinstatement of the expression phase of morphine-induced conditioned place preference in male Wistar rats under ventral tegmental area stimulation and brief inactivation

Deep brain stimulation of the lateral hypothalamus to block morphine reward: Does the intensity of stimulation matter?

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