Stimulation by parathyroid hormone of the mitochondrial utilization of reduced pyridine nucleotide

Parathyroid Hormone and the Reactions of Mitochondria to Cations*

“…Practically all the known effects of parathyroid hormone upon mitochondria, including the data of Aurbach et al (1964) and that of DeLuca (1964, 1965), can be accounted for in terms of its effects upon cation transport, the associated movements of anions, the associated uncoupling of electron transport from oxidative phosphorylation, and the accompanying mitochondrial swelling. The observations of Aurbach et al (1964) concerning an effect of hormone upon 14C02 production from succinate 1,4-14C can be explained by the uncoupling effect of the hormonally stimulated ion transport. A careful study of this system in this laboratory has shown a striking correspondence between its properties and those of the ion transport systems altered by hormone.…”

“…This particular aspect of parathyroid action is being reinvestigated in the light of these more recent findings. Most of the known facts concerning ion transport in mitochondria (Chappell et al, 1963;Chance, 1963;Chance and Yoshioka, 1965;Judah et al, 1965; Rossi and Lehninger, 1964;Chappell and Crofts, 1965;Lehninger, 1962;Rasmussen and DeLuca, 1963;Saris, 1963) and the effects of parathyroid hormone (DeLuca et al, 1962;Sallis et al, 1963;Rasmussen et al, 1964b;Fang and Rasmussen, 1964;Rasmussen et al, 1964a;Aurbach et al, 1964;DeLuca, 1964, 1965), Valinomycin (Moore and Pressman, 1964;Press-man, 1965; Ogata and Rasmussen, 1966), and…”

“…c X^onsiderable recent evidence indicates that the parathyroid hormone influences numerous parameters of mitochondrial metabolism (DeLuca et al, 1962;Sallis et al, 1963;Rasmussen et al, 1964b;Fang and Rasmussen, 1964;Rasmussen et al, 1964a;Aurbach et al, 1964; DeLuca, 1964, 1965; Rasmussen and DeLuca, 1963;. Most, but not all (Aurbach et al, 1964), of these effects have been attributed to the effect of hormone upon ion exchanges.…”

“…c X^onsiderable recent evidence indicates that the parathyroid hormone influences numerous parameters of mitochondrial metabolism (DeLuca et al, 1962;Sallis et al, 1963;Rasmussen et al, 1964b;Fang and Rasmussen, 1964;Rasmussen et al, 1964a;Aurbach et al, 1964; DeLuca, 1964, 1965; Rasmussen and DeLuca, 1963;. Most, but not all (Aurbach et al, 1964), of these effects have been attributed to the effect of hormone upon ion exchanges. In fact, a major emphasis has been placed upon hormonally stimulated anion accumulation (Sallis et al, 1963;Rasmussen et al, 1964b), leading Sallis and DeLuca (1965) to propose a primary action of the hormone upon anion transport in spite of the fact that recent studies of the mitochondrial accumulation of calcium and manganese have emphasized the primacy of energy-linked cation transport with anion transport apparently a secondary and passive process (Chappell et al, 1963.…”

Binding of Calcium by Liver Mitochondria: An Effect of Steroid Hormones in Vitamin D-Depleted and Parathyroidectomized Rats

“…This effect of the hormone is dependent either on prior treatment with or the in vitro presence of vitamin D (7). Furthermore, parathyroid hormone has been shown to facilitate mitochondrial swelling, to increase the accumulation of inorganic phosphate, magnesium and potassium, and to increase the nonphosphorylative oxidation of respiratory substrate (8)(9)(10)(11)(12)(13)(18)(19)(20).…”