Stimulation by α-Lipoic acid of glucose transport activity in skeletal muscle of lean and obese zucker rats

Henriksen, Erik J.; Jacob, Stephan; Streeper, Ryan S.; Fogt, Donovan L.; Hokama, Jason Y.; Tritschler, Hans

doi:10.1016/s0024-3205(97)00562-6

Cited by 100 publications

(46 citation statements)

References 17 publications

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“…Recent studies have found that LA treatment decreases hyperglycemia and enhances glucose uptake, a result of stimulated insulin action, in skeletal muscle of obese rats [11,18]. Likewise, in this experiment, a decrease in plasma glucose that might be attributable to enhanced glucose uptake by peripheral tissue was observed in the LA-treated chickens.…”

Section: Metabolic Responses Of La-fed Chickens To Cle Challengesupporting

confidence: 71%

Influence of lipoic acid on lipid metabolism and ?-adrenergic response to intravenous or oral administration of clenbuterol in broiler chickens

Hamano

2002

Reprod. Nutr. Dev.

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Section: Metabolic Responses Of La-fed Chickens To Cle Challengesupporting

confidence: 71%

Influence of lipoic acid on lipid metabolism and ?-adrenergic response to intravenous or oral administration of clenbuterol in broiler chickens

Hamano

2002

Reprod. Nutr. Dev.

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“…In this context, previous studies have described that LA stimulates glucose transport activity and insulin signaling in skeletal muscle of lean and obese female Zucker rats [30,31], as observed in other model of obese male rats [32].…”

Section: Discussionmentioning

confidence: 51%

Lipoic acid inhibits leptin secretion and Sp1 activity in adipocytes

Prieto-Hontoria

Pérez-Matute

Fernández‐Galilea

et al. 2011

Molecular Nutrition Food Res

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“…In animal models of diabetes, chronic LA administration increased GLUT-4 protein level in muscle membranes, improved insulin-stimulated 2-deoxyglucose uptake into isolated skeletal muscles, and reduced blood glucose level indicating that LA might enhance the capacity of insulin stimulated glucose transport and utilization in skeletal muscle (6 -8). However, LA itself was also shown to enhance glucose uptake into epitrochlearis muscles isolated from both obese (fa/fa) and lean (fa/Ϫ) Zucker rats (9).…”

mentioning

confidence: 94%

R-α-Lipoic Acid Action on Cell Redox Status, the Insulin Receptor, and Glucose Uptake in 3T3-L1 Adipocytes

Moini

Tirosh

Park

et al. 2002

Archives of Biochemistry and Biophysics

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The insulin signaling pathway has been reported to mediate R-␣-lipoic acid-(R-LA-)-stimulated glucose uptake into 3T3-L1 adipocytes and L6 myotubes. We investigated the role of the thiol antioxidant dihydrolipoic acid (DHLA) and intracellular glutathione (GSH) in R-LA-stimulated glucose transport and explored the hypothesis that R-LA could increase glucose uptake into 3T3-L1 adipocytes in an oxidant-mimetic manner. R-LA pretreatment of 3T3-L1 cells stimulated glucose transport at early time points (30 min-6 h), whereas it inhibited glucose uptake at later time points. Analysis of the oxidized and reduced content of LA in cells and medium showed that >90% of lipoic acid present was in its oxidized form. Furthermore, all oxidized forms of LA (S-, R-, and racemic LA) stimulated glucose uptake, whereas the reduced form, dihydrolipoic acid, was ineffective. Intracellular GSH levels were not changed at the early time points (before 12 h), while longer preincubation (24 -48 h) of cells with R-LA significantly increased intracellular GSH. Pretreatment of adipocytes with R-LA increased intracellular peroxide levels at early time points (30 min-6 h), after which it was decreased (12-48 h). R-LA also increased tyrosine phosphorylation of immunoprecipitated insulin receptors from 3T3-L1 adipocytes. These results indicate that (i) 3T3-L1 adipocytes have a low capacity to reduce R-LA and the oxidized form of lipoic acid is responsible for stimulating glucose uptake, (ii) R-LA modulates glucose uptake by changing the intracellular redox status, and (iii) the insulin receptor is a potential cellular target for R-LA action.

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Stimulation by α-Lipoic acid of glucose transport activity in skeletal muscle of lean and obese zucker rats

Cited by 100 publications

References 17 publications

Influence of lipoic acid on lipid metabolism and ?-adrenergic response to intravenous or oral administration of clenbuterol in broiler chickens

Influence of lipoic acid on lipid metabolism and ?-adrenergic response to intravenous or oral administration of clenbuterol in broiler chickens

Lipoic acid inhibits leptin secretion and Sp1 activity in adipocytes

R-α-Lipoic Acid Action on Cell Redox Status, the Insulin Receptor, and Glucose Uptake in 3T3-L1 Adipocytes

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