Stimulation of a Proteinase Synthesis in Bacillus Megaterium by Netropsin

Kučerová, Helena; Chaloupka, J.

doi:10.1007/978-1-4684-1274-1_10

Extracellular Enzymes of Microorganisms 1987

DOI: 10.1007/978-1-4684-1274-1_10

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Stimulation of a Proteinase Synthesis in Bacillus Megaterium by Netropsin

Helena Kučerová¹,

J. Chaloupka²

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1988

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“…The antibiotic also stimulated the synthesis of the proteinase mRNA during growth. It failed, however, to abolish its repression by amino acids or by increased temperature (KUCEROVA and CHALOUPKA 1987). Here we describe the effect of netropsin on the level of mRNA coding for the proteinase during growth and sporulation of B. megaterium.…”

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confidence: 91%

Netropsin increases formation of mRNA coding for a neutral metalloproteinase in Bacillus megaterium

Chaloupka

Kučerová

1988

J. Basic Microbiol.

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The anticancer drug netropsin increases the synthesis of an exocellular metalloproteinase during exponential growth as well as in the stationary phase of a sporulating strain of Bacillus megaterium. Its effect is due to a stimulation of the synthesis of the mRNA coding for the proteinase, determined as a residual synthesis of the enzyme in the presence of actinomycin D. The half-life of the proteinase mRNA (5-6 min at 35 degrees C) is not affected by netropsin. Netropsin relieves partially the repression of the proteinase mRNA caused by amino acids, whereas the repression brought about by an increased temperature is almost unaffected by the drug.

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mentioning

confidence: 91%

Netropsin increases formation of mRNA coding for a neutral metalloproteinase in Bacillus megaterium

Chaloupka

Kučerová

1988

J. Basic Microbiol.

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Stimulation of a Proteinase Synthesis in Bacillus Megaterium by Netropsin

Cited by 1 publication

References 6 publications

Netropsin increases formation of mRNA coding for a neutral metalloproteinase in Bacillus megaterium

Netropsin increases formation of mRNA coding for a neutral metalloproteinase in Bacillus megaterium

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