Stimulation of arachidonic acid metabolism by CCl4 in isolated rat hepatocytes

TNF-alpha dependent production of inducible nitric oxide is involved in PGE1 protection against acute liver injury

“…PGE 1 reduces plasma membrane microviscosity induced by lipid peroxidation in rat hepatocytes, suggesting that it has a stabilising effect 15. Marinovich and colleagues16 have shown that prostaglandin E 2 modifies the arachidonic acid cascade profile after activation of phospholipase A 2 by carbon tetrachloride in rat hepatocyte cultures. The antifibrotic activity of prostaglandin E 2 has also been proved 8…”

TNF-alpha but not IL-1alpha are Correlated with PGE1-Dependent Protection Against Acute D-Galactosamine-Induced Liver Injury

“…Different hypotheses have been suggested to explain the protective effect of prostaglandins in liver injury according to the different experimental models used. Among those cited are increased vascularization (5,12), reduced plasma membrane microviscosity (13), modification of the arachidonic acid cascade profile (14), antifibrotic activity (6) and immunomodulatory activity (15).…”