Stimulation of glucose uptake byMusasp. (cv. elakki bale) flower and pseudostem extracts in Ehrlich ascites tumor cells

Abstract

Banana flower and pseudostem extracts are able to promote glucose uptake into the cells, presumably through glucose transporters 1 and 3, which could be beneficial in diabetes. Glucose uptake is likely promoted by phenolic acids besides other bioactives. It can be hypothesized that consumption of nutraceutical-rich extract of banana flower and pseudostem could replace some amount of insulin being taken for diabetes.

Antidiabetic potential of Musa spp. inflorescence: a systematic review

“…cv. Elakki bale and M. paradisiaca flowers on the improvement in glucose uptake . Both evaluated the uptake of glucose using its fluorescent analogue 2‐[N‐(7‐nitrobenz‐2‐oxa‐1,3‐diazol‐4‐yl)amino]‐2‐deoxy‐D‐glucose (2‐NBDG).…”

“…Ehrlich ascites tumour (EAT) cells were chosen as a cellular model by Bhaskar and colleagues . This model was also utilized in other studies of glucose transport .…”

“…In the sequence, the cells were centrifuged, washed with buffer, lysed, suspended in buffer with Triton X‐100 and sonicated. Finally, they were centrifuged again and the supernatant was analysed by spectrofluorimeter to measure the fluorescent analogue of glucose …”

“…They were obtained by subtracting the values of the control from that of the cells pretreated with the extract and 2‐NBDG. The basal glucose uptake (EAT cells + 2‐NBDG) was considered as a control …”

Anti-cancer potential of banana flower extract: An <i>in vitro</i> study

“…The extract has anti-oxidant property that prevents free radicals and control cell and tissue damage. Bhaskar et al, (2011) reported that glucose uptake in Ehrlich ascites tumor cells was stimulated by banana (Musa sp.) flower and pseudostem extracts.…”