Stimulation of Na+/K+-ATPase with an Antibody against Its 4thExtracellular Region Attenuates Angiotensin II-Induced H9c2 Cardiomyocyte Hypertrophy via an AMPK/SIRT3/PPARγSignaling Pathway

Xiong, Shaojun; Sun, Hai-Jian; Cao, Lei; Zhu, Mengyuan; Liu, Tengteng; Wu, Zhiyuan; Bian, Jun

doi:10.1155/2019/4616034

Cited by 23 publications

(14 citation statements)

References 60 publications

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“…The cell apoptosis was also caused by protein produced by the heat of burn (Papaliagkas et al 2007, Nielson et al 2017. Hypernatremia condition was signed of osmotic injury that could accelerate the apoptosis process of cell (Elmore 2007, Xiong et al 2019. Without sufficient perfusion of recipient bed, revascularization was not achieved, thus caused disrupt of healing process of skin graft.…”

Section: Discussionmentioning

confidence: 99%

High Risk of Failed Skin Graft on Major Burn Patients with Complication of Hypernatremia

Hariani

Budi

Wulandari

2021

FMI

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The rate of failed skin graft in Dr. Soetomo General Academic Hospital Surabaya was around 26% of the cases, and it became a concern because skin graft was the main procedure to close large burn wounds. Many problems might affect this event; one of them was electrolyte imbalance. Hypernatremia was found in major burn patients. This condition disrupted the wound healing process of skin graft. This cross-sectional study evaluated patients with burns admitted to the Burn Centre of Dr. Soetomo Hospital between January 2014 and December 2018. 143 subjects participated in this study. Hypernatremia was found in 16% of all subjects (23 subjects), 19% with hypernatremia (28 subjects), and the majority of it, 65% with normonatremia (92 subjects). This study found that the risk of failed skin graft was higher on hypernatremia than normonatremia subjects. This risk was higher if the skin graft procedure took more than 10%.

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Section: Discussionmentioning

confidence: 99%

High Risk of Failed Skin Graft on Major Burn Patients with Complication of Hypernatremia

Hariani

Budi

Wulandari

2021

FMI

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“…Sirt3 can also maintain the redox balance and metabolism of mitochondria under physiological and pathological conditions plays a crucial role in the pathogenesis of cardiovascular diseases [20]. In most mammalian cells, sodium potassium Na + -K + -ATPase is an energy-transducing ion pump across the plasma membrane [21]. Na + and K + channels are closely related to electro cardio and are involved in maintaining and stabilizing electrical activity features of myocardial cells and myocardium [22].…”

Section: Discussionmentioning

confidence: 99%

Mongolian Medicinal Formula Anshen-Buxin-Liuwei Pill Alleviate Cardiomyocyte Hypoxia/Reoxygenation Injury via Mitochondrion Pathway

Huang

Tong

Huang

et al. 2021

Preprint

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Anshen Buxin Liuwei pill (ABLP), a Mongolian medicinal formula, composed of the six medicinal materials of Mongolian medicine Bos taurus domesticus Gmelin, Choerospondias axillaris (Roxb. ) Burtt et Hill, Myristica fragrans Houtt., Eugenia caryophµllata Thunb., Aucklandia lappa Decne., Liqui dambar formosana Hance, is considered to have a therapeutic effect on the symptoms such as coronary heart disease, angina pectoris, arrhythmia, depression and irritability, palpitation, and shortness of breath. Therefore, the present study was employed a network pharmacology approach to identify the potentially active ingredients and to evaluate the protective effect of ABLP on hypoxia/reoxygenation (HR)-induced H9c2 cardiomyocytes, and its influence on cell viability, apoptosis, oxidative stress. H9c2 cardiomyocytes were used to construct a HR injury model. CCK-8 assay and AnnexinV-FITC cell apoptosis assays were used for cell viability and cell apoptosis determination. The levels of LDH, SOD, MDA, CAT, CK, GSH-Px, Na+-K+-ATPase, and Ca2+-ATPase in the cells were determined to assess the effect of ABLP. the mRNA levels of Sirtuin3 (Sirt3) and Cytochrome C (Cytc) in H9c2 cells were determined by quantitative real-time PCR. The finding of this study indicates that HR treatment cells began to shrink from the spindle in an irregular shape with some floated in the medium, well by increasing the therapeutic dose of ABLP (5 µg/mL, 25 µg/mL, and 50 µg/mL), the cells gradually reconverted in a concentration-dependent manner. The release of CK in HR-treated cells was significantly increased, indicating that ABLP exerts a protective effect in H9c2 cells against HR injury and can improve the mitochondrial energy metabolism and mitochondrial function integrity. The present study scrutinized the cardio-protective effect of ABLP against the HR-induced H9c2 cells injury through antioxidant and mitochondrion pathways. ABLP could be a promising therapeutic drug for the treatment of myocardial ischemic cardiovascular disease. The results will provide reasonable information for clinical use of the ABLP.

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“… 73 Leucine-zipper and sterile-α motif kinase selective inhibitor 3h demonstrated promising in vivo anti-HCM efficacy in a rat disease model and showed that the clinical drug–drug interaction potential could be well monitored for 3 h. 74 Stimulation of Na + /K + -ATPase with DR-Ab attenuated angiotensin II-induced cardiomyocyte hypertrophy by activating the AMPK/Sirt-3/PPARγ pathway. 75 …”

Section: Hypertrophic Cardiomyopathymentioning

confidence: 99%

Cardiomyopathies in China: A 2018–2019 state‐of‐the‐art review

Hua

Zhang

2020

Chronic Diseases and Translational Medicine

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Cardiomyopathies are diseases of the cardiac muscle and are often characterized by ventricular dilation, hypertrophy, and cardiac arrhythmia. Patients with cardiomyopathies often experience sudden death and cardiac failure and require cardiac transplantation during the course of disease progression. Early diagnosis, differential diagnosis, and genetic consultation depend on imaging techniques, genetic testing, and new emerging diagnostic tools such as serum biomarkers. The molecular genetics of cardiomyopathies has been widely studied recently. The discovery of mechanisms underlying heterogeneity and overlapping of the phenotypes of cardiomyopathies has revealed the existence of disease modifiers, and this has led to the emergence of novel disease-modifying therapy. This 2018–2019 state-of-the-art review outlines the pathogenesis, diagnosis, and treatment of cardiomyopathies in China.

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Stimulation of Na⁺/K⁺-ATPase with an Antibody against Its 4^thExtracellular Region Attenuates Angiotensin II-Induced H9c2 Cardiomyocyte Hypertrophy via an AMPK/SIRT3/PPARγSignaling Pathway

Cited by 23 publications

References 60 publications

High Risk of Failed Skin Graft on Major Burn Patients with Complication of Hypernatremia

High Risk of Failed Skin Graft on Major Burn Patients with Complication of Hypernatremia

Mongolian Medicinal Formula Anshen-Buxin-Liuwei Pill Alleviate Cardiomyocyte Hypoxia/Reoxygenation Injury via Mitochondrion Pathway

Cardiomyopathies in China: A 2018–2019 state‐of‐the‐art review

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