1996
DOI: 10.1159/000203787
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Stimulation of Newborn-Like Hemoglobin Synthesis in Adult Rats by Recombinant Human Erythropoietin and Suppression by Aspirin

Abstract: A study was carried out to determine whether recombinant human erythropoietin can induce newborn-like hemoglobin synthesis in adult rats. A fixed dose of recombinant erythropoietin was administered each time intravenously in each rat for altogether 5 weeks. Blood samples drawn at 7-day intervals were analyzed by DEAE-cellulose chromatography. Hematological parameters like red blood cell counts, hematocrit values and reticulocyte counts were evaluated and compared. A significant changing pattern for certain hem… Show more

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