Stimulation of Prostaglandin Production by Quinolone Phototoxicity in Balb/c 3T3 Mouse Fibroblast Cells in Vitro

Use of human reconstituted epidermis Episkin® for assessment of weak phototoxic potential of chemical compounds

“…The lower toxic effect of ofloxacin is related to its chemical structure: UVA radiation easily degrade quinolones, which possess fluorine at the 8 position of the quinolone ring, increasing their toxicity. Ofloxacin, without fluorine at this position, therefore shows a weaker phototoxic activity (26).…”