Stimulation of regulatory T cell circuits by immunoglobulin‐dependent structures on activated B cells

L’age-Stehr, Johanna; Teichmann, Herbert; Gershon, Richard K.; Cantor, Harvey

doi:10.1002/eji.1830100105

Cited by 52 publications

(20 citation statements)

References 22 publications

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“…This perturbation of the "steady-state'' could be an antigenic stimulus for suppressor cells recognizing the expanded set of Id, whose activation would result in a control of B cell clonal expansion. This hypothetical series of events has, in fact, recently been confirmed concerning the activation of Id helper T cells [41] and antigen-specific suppressor cells [42].…”

Section: Discussionmentioning

confidence: 92%

Idiotype regulation: evidence for the involvement of Igh‐C‐restricted T cells in the M‐460 idiotype suppressive pathway

et al. 1982

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Allotypic restriction of idiotype suppression has been shown in several idiotypic systems. It has also been demonstrated that naive BALB/c mice contain naturally occurring suppressor T cells capable of inhibiting the M-460 idiotype expressed on BALB/c B cells, and that T cells from allotype-congenic mice have no effect on this expression. Since we have previously shown that upon polyclonal activation B cells of all mice tested are capable of secreting M-460-positive anti-2,4,6-trinitrophenyl (TNP) antibodies, we postulated that idiotype suppressor cells may recognize idiotypes in conjugation with products of the Igh loci. In the present study we tested this hypothesis. The data clearly showed that regardless of their allotypic haplotype all strains of mice do possess suppressor cells capable of recognizing the M-460 idiotype. However, mixing experiments indicated that the functional potential of these suppressor cells can only be expressed when T and B lymphocytes come from allotype-matched animals. Efficient suppression in those cultures containing allotype-matched but incompatible B and T cells at the I-J region of the H-2 locus could be detected. Finally, using allotypic recombinant strains of mice, we found evidence that the restrictive elements in idiotypic suppression are the product of genes mapping in the Igh-C locus, or closely linked to it.

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Section: Discussionmentioning

confidence: 92%

Idiotype regulation: evidence for the involvement of Igh‐C‐restricted T cells in the M‐460 idiotype suppressive pathway

et al. 1982

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“…There, it was found that the i.v. injection of syngeneic B cell blasts, but not T cell blasts, into normal mice resulted in the activation of Lytl T cells which produced a GvH or HvG reaction in syngeneic recipient mice [15]. We found T cell-mediated in vivo responses to transferred syngeneic T and B cell blasts with identical numbers of injected blast-response relationship and identical kinetics [9].…”

Section: Discussionmentioning

confidence: 84%

Lymphoblastogenesis stimulates proliferation of interacting Lyt1 T cells in a syngeneic system

1981

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The intravenous transfer of polyclonally activated lymphoblasts elicited a proliferative response of host-derived Lyt1 T cells in the spleens of syngeneic recipient mice. These Lyt1 T cells (responding in vivo to a syngeneic lymphoblast graft) stimulated proliferation of resting, syngeneic splenic Lyt1 T cells, derived from uninjected mice, in a one-way syngeneic mixed lymphocyte culture in vitro. The data are discussed in the context of T cell activation induced by lymphoblastogenesis in a syngeneic system.

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“…It is possible that T cells in the normal spleen cell population interact with the antigenspecific immune spleen cells to generate idiotype-specific suppressor T cells (21). It is known that Ig-associated structures on activated B cells can trigger Ly-1+2 -inducer cells to stimulate Ly-2 ÷ T suppressor activity (22). Mechanisms such as these could explain how the removal of T cells from the normal spleen cell population can decrease suppression.…”

Section: Discussionmentioning

confidence: 99%

Cellular interactions in immune regulation. Hapten-specific suppression by non-T cells and T cell-mediated reversal of suppression

Dekruyff¹,

Simonson²,

Siskind³

1981

The Journal of Experimental Medicine

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The ability of lymphoid cells from immunized animals to regulate the response of naive B ceils to the immunizing hapten was studied. Mice were immunized with trinitrophenylated (TNP) bovine gamma globulin (BGG) in complete Freund's adjuvant, and their spleen cells were examined in vivo and in vitro for the presence of specific inhibitory activity. This activity was found to peak 1 wk after immunization, was active against TNP on both T-dependent (BGG) and T-independent (Ficoll and polyacrylamide beads) carriers, and was demonstrable both by mixed cell transfers and mixed cell culture experiments. In in vitro studies, it was shown that the inhibition of the response to TNP- polyacrylamide beads by immune spleen cells was mediated by a non-T cell, possibly a B cell, because the suppressor activity was enriched in a purified B cell preparation. A role for macrophages was not formally ruled out. A specific suppressor factor was produced in vitro by immune spleen cells cultured in the absence of antigen. The suppressor activity was modulated by T .cells because elimination of T cells from the normal spleen cell population decreased suppression; elimination of T cells from the immune spleen cell population did not effect suppression, but elimination of T cells from both the normal and immune spleen cell populations allowed the expression of marked specific suppression. Thus, T cells present in the normal spleen cell population augment the degree of suppression, whereas T cells present in the immune spleen cell population decrease the degree of suppression; that is, T cells present in the immune spleen cell population had the ability to specifically abrogate suppression ("abrosuppression") in a T-independent immune response. It is proposed that the response to a T- independent antigen is regulated by specific suppressor activity generated by a non-T cell and augmented by the interaction of this cell with a T cell. The suppressor activity can be blocked by a specific abrosuppressor T cell. It is suggested that, because suppressor activity appears dominant in the naive state of the immune system, the induction of specific abrosuppressor activity may be essential if an immune response is to take place.

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Stimulation of regulatory T cell circuits by immunoglobulin‐dependent structures on activated B cells

Cited by 52 publications

References 22 publications

Idiotype regulation: evidence for the involvement of Igh‐C‐restricted T cells in the M‐460 idiotype suppressive pathway

Idiotype regulation: evidence for the involvement of Igh‐C‐restricted T cells in the M‐460 idiotype suppressive pathway

Lymphoblastogenesis stimulates proliferation of interacting Lyt1 T cells in a syngeneic system

Cellular interactions in immune regulation. Hapten-specific suppression by non-T cells and T cell-mediated reversal of suppression

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