Stimulation of sensory neurons improves cognitive function by promoting the hippocampal production of insulin-like growth factor-I in mice

Harada, Naoaki; Narimatsu, Noriko; Kurihara, Hiroki; Nakagata, Naomi; Okajima, Kenji

doi:10.1016/j.trsl.2009.05.001

Cited by 22 publications

(15 citation statements)

References 46 publications

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“…Capsaicin intracisternal injection increased the expression of c‐Fos in TNC in guinea pigs, and this response was inhibited by valproic acid, an established antimigraine drug 116,117 . When CGRP‐knockout mice were challenged with capsaicin, there was a significantly decreased expression of c‐Fos compared to the wild‐type mice 118 . Furthermore, when capsaicin was injected unilaterally in the face of rat, olcegepant pretreatment decreased neuronal activation in the TNC, but not in the TG, 119 indicating a central site of action.…”

Section: Calcitonin Gene‐related Peptide and Migrainementioning

confidence: 99%

Chemical Mediators of Migraine: Preclinical and Clinical Observations

2011

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Migraine is a neurovascular disorder, and although the pathophysiology of migraine has not been fully delineated, much has been learned in the past 50 years. This knowledge has been accompanied by significant advancements in the way migraine is viewed as a disease process and in the development therapeutic options. In this review, we will focus on 4 mediators (nitric oxide, histamine, serotonin, and calcitonin gene-related peptide) which have significantly advanced our understanding of migraine as a disease entity. For each mediator we begin by reviewing the preclinical data linking it to migraine pathophysiology, first focusing on the vascular mechanisms, then the neuronal mechanisms. The preclinical data are then followed by a review of the clinical data which support each mediator’s role in migraine and highlights the pharmacological agents which target these mediators for migraine therapy.

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Section: Calcitonin Gene‐related Peptide and Migrainementioning

confidence: 99%

Chemical Mediators of Migraine: Preclinical and Clinical Observations

2011

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“…Moreover, CGRP seems to set in motion an array of other neuroprotective processes: It activates antiapoptotic signaling via the cyclic AMP response element‐binding transcription factor (CREB) and B cell lymphoma 2 survival protein (Bcl‐2), promotes neurotrophic signaling via insulin‐like growth factor‐1 (IGF‐1), basic fibroblast growth factor (bFGF), and nerve growth factor (NGF), reduces brain edema by inhibiting overexpression of aquaporin‐4 and, as noted, strengthens the BBB …”

Section: Neuroprotective Properties Of Cgrp Within the Brainmentioning

confidence: 96%

“…The antidepressant properties seem to be mediated by increased NGF and markedly increased angiogenesis in the hippocampus . Further, the CGRP‐mediated release of hippocampal IGF‐1 improves neurogenesis and cognition . Conversely, CGRP knockout mice seem to have impaired spatial learning, apparently because of lower IGF‐1 levels …”

Section: Neuroprotective Properties Of Cgrp Within the Brainmentioning

confidence: 99%

“…Further, the CGRP‐mediated release of hippocampal IGF‐1 improves neurogenesis and cognition . Conversely, CGRP knockout mice seem to have impaired spatial learning, apparently because of lower IGF‐1 levels …”

Section: Neuroprotective Properties Of Cgrp Within the Brainmentioning

confidence: 99%

“…CGRP is involved in pain transmission from the periphery through the trigeminal ganglion to the trigeminal nucleus caudalis within the brain. However, capsaicin‐sensitive pain fibers from the periphery also transmit signals to the parabrachial nuclei, which in turn relay the signal to the dentate gyrus of the hippocampus, increasing neurogenesis, angiogenesis, synaptic function, and cognitive performance . That is, there is a rather direct link between nociceptive stimulation in the periphery and neurogenesis in the hippocampus.…”

Section: Neuroprotective Consequences Of Cgrp Outside the Blood‐brainmentioning

confidence: 99%

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CGRP and Brain Functioning: Cautions for Migraine Treatment

Borkum

2019

Headache

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Background Calcitonin gene‐related peptide has emerged as a therapeutic target in migraine. Monoclonal antibodies and small molecule receptor antagonists (gepants) directed against CGRP have been approved or are in Phase II or III clinical trials. For monitoring the long‐term safety of these drugs, it is helpful to consider the role of CGRP in brain functioning. Methods Qualitative review of the preclinical literature on CGRP in brain physiology and pathophysiology. Results Within the brain, CGRP is upregulated by stresses such as ischemia, injury, hyperthermia, and seizure, and activates neuroprotective processes. Thus, CGRP buffers intracellular calcium, triggers antiapoptotic signaling, upregulates a number of neurotrophins (including insulin‐like growth factor‐1/IGF‐1, basic fibroblast growth factor/bFGF, and nerve growth factor/NGF), reduces brain edema, and likely increases antioxidant defenses. When released outside the blood‐brain barrier, CGRP likely protects the endothelium, upregulates growth factor signaling from the endothelium to the brain parenchyma, strengthens the blood‐brain barrier, protects the immune privilege of the brain by inhibiting the movement of neutrophils and monocytes, and facilitates neurogenesis and angiogenesis at stem cell niches. Conclusions CGRP participates in a wide range of neuroprotective processes. In theory, migraineurs with comorbid brain pathology might be at increased risk from CGRP inhibition. However, the extent of compensating processes is unknown and will determine whether these risks materialize in practice.

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Vegetable Fruits: A Cornucopia of Health Benefits

Lister

2013

Bioactives in Fruit

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Stimulation of sensory neurons improves cognitive function by promoting the hippocampal production of insulin-like growth factor-I in mice

Cited by 22 publications

References 46 publications

Chemical Mediators of Migraine: Preclinical and Clinical Observations

Chemical Mediators of Migraine: Preclinical and Clinical Observations

CGRP and Brain Functioning: Cautions for Migraine Treatment

Vegetable Fruits: A Cornucopia of Health Benefits

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