Stimulation of Sulfonamides Antibacterial Drugs Activity as a Result of Complexation with Ru(III): Physicochemical and Biological Study

Spisz, Paulina; Chylewska, Agnieszka; Królicka, Aleksandra; Ramotowska, Sandra; Dąbrowska, Aleksandra; Makowski, Mariusz

doi:10.3390/ijms222413482

Cited by 15 publications

(13 citation statements)

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“…The EB is described by a high value of the binding constant to the DNA, and its thermodynamic characteristic of binding to the said biomolecule has been well described in other types of experiments. − The sulfonamides have been selected as the main research object due to their proven antibiotic and anticancer properties. − Therefore, the second small compound that has been selected for the research was sulfathiazole (STZ), a chemotherapeutic agent with a strong bacteriostatic effect. Its interaction with DNA in solutions was proven by our group using spectrophotometric titration . It was previously confirmed that STZ was also a promising ligand for the formation of complexes with transition metal ions (e.g., Ru(III)) and that the complexation improved its antimicrobial and anticancer properties .…”

Section: Introductionmentioning

confidence: 95%

Application of the SwitchSense Technique for the Study of Small Molecules’ (Ethidium Bromide and Selected Sulfonamide Derivatives) Affinity to DNA in Real Time

et al. 2022

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The discovery and introduction of the switchSense technique in the chemical laboratory have drawn well-deserved interest owing to its wide range of applications. Namely, it can be used to determine the diameter of proteins, alterations in their tertiary structures (folding), and many other conformational changes that are important from a biological point of view. The essence of this technique is based on its ability to study of the interactions between an analyte and a ligand in real time (in a buffer flow). Its simplicity, on the other hand, is based on the use of a signaling system that provides information about the ongoing interactions based on the changes in the fluorescence intensity. This technique can be extremely advantageous in the study of new pharmaceuticals. The design of compounds with biological activity, as well as the determination of their molecular targets and modes of interactions, is crucial in the search for new drugs and the fight against drug resistance. This article presents another possible application of the switchSense technique for the study of the binding kinetics of small model molecules such as ethidium bromide (EB) and selected sulfonamide derivatives with DNA in the static and dynamic modes at three different temperatures (15, 25, and 37 °C) each. The experimental results remain in very good agreement with the molecular dynamics docking ones. These physicochemical insights and applications obtained from the switchSense technique allow for the design of an effective strategy for molecular interaction assessments of small but pharmaceutically important molecules with DNA.

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Section: Introductionmentioning

confidence: 95%

Application of the SwitchSense Technique for the Study of Small Molecules’ (Ethidium Bromide and Selected Sulfonamide Derivatives) Affinity to DNA in Real Time

et al. 2022

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“…Bacteriostatic dosages of sulfonamides are used to prevent or limit bacterial proliferation. Sulfonamides hinder bacteria from producing folic acid, which has a bacteriostatic effect (Sánchez-Osuna et al, 2019;Nunes et al, 2020;Spisz et al, 2021). Bacteria produce folic acid on their own, by using endogenous chemicals and enzymes.…”

Section: Sulfa Drugs Used In the Treatment Sulfa Drugs Act As An Anti...mentioning

confidence: 99%

“…In the early twentieth century, antibiotics were first utilised as growth enhancers in farm animals, which led to their introduction into the everyday human diet. As a result, a significant and hitherto unforeseen phenomenon emerged: the emergence of antibiotic resistance in bacteria (Dodds, 2017;Spisz et al, 2021). Antibiotic resistance causes 2.8 million illnesses in the United States every year.…”

Section: Introductionmentioning

confidence: 99%

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The Role of Sulfa Drugs in our Life

Merali¹,

AL-Hadedi²,

Abood³

2022

RJS

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Gerhardt Dumac discovered in 1932 that Prontosyl kills bacteria while testing dyes, and in 1934, he began using Prontosyl as a treatment. This was in Germany, and experiments in France showed that the effect of Prontosyl is due to the presence of sulfanilamide in it. In 1908, Gelmo was the first to attend a sulfa drug conference in Germany. Sulfanilamide's medicinal usefulness was endorsed in 1936 by researchers at Johns Hopkins University in the United States, including Long and Plus, Marshall, and others. Sulfa drugs are used to treat a range of diseases caused by bacteria, with which it has been possible to save countless lives. It is believed that the effect of sulfa is to stop the growth of bacteria, meaning that these drugs prevent the growth and reproduction of bacteria, which creates an opportunity for the body's defensive forces to eliminate them. Humans are currently treated with sulfonamides for specific disorders, such as urinary system infections. However, sulfonamides are more typically seen in veterinary medicine. Therefore we attempted to explain the role and importance of sulfa drugs in our lives because of their widespread use in medical therapy.

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“…Through simple ligands substitution or modification, ruthenium complexes with different properties can be achieved. [ 18,28,29 ] Therefore, optimizing the properties of ruthenium complexes by changing the coordinated ligands has aroused a considerable research interest. [ 30 ] Previously, we have designed and synthesized some ruthenium complexes bearing different functional ligands with good antibacterial activities against Gram‐positive bacteria.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and antibacterial against Staphylococcus aureus of new ruthenium (II) polypyridine complexes containing pyrene groups

Wei

Wang

et al. 2022

Applied Organom Chemis

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As the treatment of Staphylococcus aureus infection becomes more and more difficult, it is particularly important to develop new antibacterial agents against S. aureus infection. Herein, three ruthenium (II) complexes containing pyrene groups, [Ru (bpy)2(PYIP)](PF6)2 (Ru‐1), [Ru (dtbpy)2(PYIP)](PF6)2 (Ru‐2), and [Ru (ttbpy)2(PYIP)](PF6)2 (Ru‐3) (PYIP = 2‐(pyren‐1‐yl‐1H‐imidazo[4,5‐f][1,10]phenanthroline, bpy = 2,2′‐bipyridine, dtbpy = 4,4′‐dimethyl‐2,2′‐bipyridine and ttbpy = 4,4′‐di‐tert‐butyl‐2,2′‐bipyridine) were designed and synthesized. The antibacterial activities of them against S. aureus were evaluated by determining the minimum inhibitory concentration and minimum bactericidal concentration. The results showed that three ruthenium complexes had excellent antibacterial activities against S. aureus. Among them, Ru‐2 exhibited the best bacteriostatic concentration and bactericidal activities, which was selected for the further antibacterial mechanism exploring. Ru‐2 can obviously inhibit the growth of bacterial biofilm, and the drug resistance results showed that Ru‐2 can effectively prevent the development of bacterial resistance. Moreover, the in vivo antibacterial activity of Ru‐2 was evaluated by establishing mouse infection model with the results that Ru‐2 could effectively inhibit the growth of bacteria and make mouse wounds heal faster.

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Stimulation of Sulfonamides Antibacterial Drugs Activity as a Result of Complexation with Ru(III): Physicochemical and Biological Study

Cited by 15 publications

References 72 publications

Application of the SwitchSense Technique for the Study of Small Molecules’ (Ethidium Bromide and Selected Sulfonamide Derivatives) Affinity to DNA in Real Time

Application of the SwitchSense Technique for the Study of Small Molecules’ (Ethidium Bromide and Selected Sulfonamide Derivatives) Affinity to DNA in Real Time

The Role of Sulfa Drugs in our Life

Synthesis and antibacterial against Staphylococcus aureus of new ruthenium (II) polypyridine complexes containing pyrene groups

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