Stimulation of the immune response against SRBC by reduction of corticosterone plasma levels

Dijk, Hans van; Testerink, Janwillem; Noordegraaf, E. M.

doi:10.1016/0008-8749(76)90092-7

Cited by 14 publications

(3 citation statements)

References 9 publications

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“…Plasma corticoid levels regulate the effector part of immunity against several pathogens, and elevated plasma corticoid levels decrease the number of circulating lymphocytes and monocytes, which are important for control of malaria [45,46]. Cortisol reduces the adherence of infected erythrocytes to monocytes [47].…”

Section: Discussionmentioning

confidence: 99%

Cortisol and susceptibility to malaria during pregnancy

Bouyou-Akotet

Adegnika

Agnandji

et al. 2005

Microbes and Infection

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Section: Discussionmentioning

confidence: 99%

Cortisol and susceptibility to malaria during pregnancy

Bouyou-Akotet

Adegnika

Agnandji

et al. 2005

Microbes and Infection

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“…However, it is possible that the effect of stress may be initially to inhibit the access of mobilising signals to the site or sites of release of the mononuclear celts by changing vascular permeability. The existence of a htimoral regulatory mechanistn that controls monocyte production has been demonstrated (Van Waarde, Hulsing-Hesselink and Van Furth, 1976;1977a and b). Kmc, M, G, (1973) The production of mdcrophages in the rat.'…”

Section: Discussionmentioning

confidence: 99%

The Effect of Stress on the Migration of Leucocytes Into the Peritoneal Cavity of Rats Following Injection of an Inflammatory Agent

Bassett

Tait

1981

Aust J Exp Biol Med

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Summary. Although previous studies have shown ihal Ihe injection of exogenous corliccsteroids suppresses the infliimmatory response, no study has been made on the effecl on inflammation of endoeenous cortieosieroids released in response to stress, [n the present study ;i reduction was observed in the total number of leucocytes migtaling into the peritoneal cavity of stressed rats in response to the injection of an inllammalary agent. The reduction in tolal counts was due to & stress-induced reduction of both polymorph and mononuclear cells. Permeability studies iind blood leucocyte counts were conducted to deiermine the mode of action of the stress induced reduction of leucocyte migr.ition. In ihe case of the polymorphs. evidence is presented lo implicate both a reduced release of these cells into the blood stream from storage sites and a blockade of the increased vascular permeability. The situation is not as clear for the mononuclear cells where no change in the circulating levels of these cells was observed in either stressed or control rats following induction of an inflammatory response.

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“…T-cells and macrophages are important in malaria immunity (19,26,41,44,52), and changes in activity of these cells during pregnancy could lead to loss of immunity. It is well known that elevated plasma corticoid levels decrease the number as well as the activity of circulating lymphocytes and monocytes (2,43,(47)(48)(49)). Since T-suppressor cells are less sensitive to corticoid (54), a relative increase of suppressor T-cells during pregnancy (29) has been taken to explain pregnancy-associated immunodepression (7,14).…”

Section: Recrudescence During Pregnancy a High Per-mentioning

confidence: 99%

Corticosterone regulation of the effector function of malarial immunity during pregnancy

Zon¹,

Eling²,

Hermsen³

et al. 1982

Infect Immun

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In the experimental Plasmodium berghei mouse model, as in human malaria, reduced maternal responsiveness and even loss of immunity were observed during pregnancy. Loss of immunity in the second half of pregnancy occurred during a period of elevated plasma corticoid levels. Further analysis showed that plasma corticoid levels were significantly higher in immunodepressed mice than in mice that remained immune throughout pregnancy. Plasma corticosterone levels differed increasingly from those in mice with persistent immunity towards recrudescence. In nonimmune infected controls, however, only a slight increase in plasma corticosterone, already present during the subpatent period, was measured. Blocking of maternal corticoid production by adrenalectomy delayed the increase of plasma corticosterone (fetoplacental origin) and reduced the number of mice that lost immunity during pregnancy considerably. The role of various plasma corticoid levels in the regulation of effector function of immunity during pregnancy is discussed.

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Stimulation of the immune response against SRBC by reduction of corticosterone plasma levels

Cited by 14 publications

References 9 publications

Cortisol and susceptibility to malaria during pregnancy

Cortisol and susceptibility to malaria during pregnancy

The Effect of Stress on the Migration of Leucocytes Into the Peritoneal Cavity of Rats Following Injection of an Inflammatory Agent

Corticosterone regulation of the effector function of malarial immunity during pregnancy

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