Stimulation of the nucleus accumbens as behavioral reward in awake behaving monkeys

Bichot, Narcisse P.; Heard, Matthew; Desimone, Robert

doi:10.1016/j.jneumeth.2011.05.025

Cited by 20 publications

(14 citation statements)

References 32 publications

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“…One surprising results from stimulation of the striatum is that we did not find improved appetitive behavior, as observed previously during stimulation of the vSTR (Bichot et al, 2011) and Caudate nucleus (Williams & Eskandear, 2006). This discrepancy with previous results may reflect differences in the stimulation period that we chose (CS presentation vs. outcome delivery) and the context (appetitive-aversive) of the stimulation.…”

Section: Microstimulation During Css Presentation Is An Effective Toocontrasting

confidence: 85%

Disturbance of approach‐avoidance behaviors in non‐human primates by stimulation of the limbic territories of basal ganglia and anterior insula

Saga

Ruff

Tremblay

2018

Eur J of Neuroscience

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The basal ganglia (BG) are involved in motivation and goal‐directed behavior. Recent studies suggest that limbic territories of BG not only support reward seeking (appetitive approach) but also the encoding of aversive conditioned stimuli (CS) and the production of aversive‐related behaviors (avoidance or escape). This study aimed to identify inside two BG nuclei, the striatum and pallidum, the territories involved in aversive behaviors and to compare the effects of stimulating these territories to those resulting from stimulation of the anterior Insula (aIns), a region that is well‐known to be involved in aversive encoding and associated behaviors. Two monkeys performed an approach/avoidance task in which they had to choose a behavior (approach or avoidance) in an appetitive (reward) or aversive (air‐puff) context. During this task, either one (single‐cue) or two (dual‐cue) CS provided essential information about which context‐adapted behavior should be selected. Microstimulation was applied during the CS presentation. Stimulation generally reduced approaches in the appetitive contexts and increased escape behaviors (premature responses) and/or passive avoidance (noninitiated action) in aversive context. These effects were more pronounced in ventral parts of all examined structures, with significant differences observed between stimulated structures. Thresholds to induce effects were lowest in the pallidum. Striatal stimulation led to the largest diversity of effects, with a subregion even leading to enhanced active avoidance. Finally, aIns stimulations produced stronger effects in the dual‐cue context. These results provide causal evidence that limbic territories of BG, like aIns, play crucial roles in the selection of context‐motivated behaviors.

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Section: Microstimulation During Css Presentation Is An Effective Toocontrasting

confidence: 85%

Disturbance of approach‐avoidance behaviors in non‐human primates by stimulation of the limbic territories of basal ganglia and anterior insula

Saga

Ruff

Tremblay

2018

Eur J of Neuroscience

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“…These regions include NA, striatum, amygdala, OFC, lateral hypothalamus, mediodorsal nucleus, and locus coeruleus [38, 39, 41–43]. Interestingly, the majority of these sites contain a high density of dopamine receptors and many of these same regions showed increased fMRI activity in response to VTA-EM and unexpected juice rewards (see Figure 4, Table S2).…”

Section: Comparison With Reinforcing Stimulation In Monkeymentioning

confidence: 99%

Role of the Primate Ventral Tegmental Area in Reinforcement and Motivation

et al. 2014

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Summary Monkey electrophysiology [1, 2] suggests that the activity of the ventral tegmental area (VTA) helps regulate reinforcement learning and motivated behavior, in part by broadcasting prediction-error signals throughout the reward system. However, electrophysiological studies do not allow causal inferences regarding the activity of VTA neurons with respect to these processes, as this requires artificial manipulation of neuronal firing. Rodent studies fulfilled this requirement by demonstrating that electrical and optogenetic VTA stimulation can induce learning and modulate downstream structures [3–7]. Still, the primate dopamine system has diverged significantly from that of rodents, exhibiting greatly-expanded and uniquely-distributed cortical and subcortical innervation patterns [8]. Here we bridge the gap between rodent perturbation studies and monkey electrophysiology using chronic electrical microstimulation of macaque VTA (VTA-EM). VTA-EM was found to reinforce cue selection in an operant task and to motivate future cue selection using a Pavlovian paradigm. Moreover, by combining VTA-EM with concurrent functional magnetic resonance imaging (fMRI), we demonstrated that VTA-EM increased fMRI activity throughout most of the dopaminergic reward system. These results establish a causative role for primate VTA in regulating stimulus-specific reinforcement and motivation as well as modulating activity throughout the reward system.

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“…The carbon-PEEK stimulation chamber was designed for bilateral stimulation of reward-related structures of the brain (e.g., nucleus accumbens, VTA) near the midline [10]. Like the recording chamber, the guide holes for the screws are encased within the wall of the chamber itself, preventing the need for the use of protruding feet for securing the chamber to the skull and instead allowing for a smooth and uninterrupted interface between the edge of the device and the skin margin.…”

Section: Resultsmentioning

confidence: 99%

Custom-fit radiolucent cranial implants for neurophysiological recording and stimulation

Mulliken

Bichot

Ghadooshahy

et al. 2015

Journal of Neuroscience Methods

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Background Recording and manipulating neural activity in awake behaving animal models requires long-term implantation of cranial implants that must address a variety of design considerations, which include preventing infection, minimizing tissue damage, mechanical strength of the implant, and MRI compatibility. New Method Here we address these issues by designing legless, custom-fit cranial implants using structural MRI-based reconstruction of the skull and that are made from carbon-reinforced PEEK. Results We report several novel custom-fit radiolucent implant designs, which include a legless recording chamber, a legless stimulation chamber, a multi-channel microdrive and a head post. The fit to the skull was excellent in all cases, with no visible gaps between the base of the implants and the skull. The wound margin was minimal in size and showed no sign of infection or skin recession. Comparison with Existing Methods Cranial implants used for neurophysiological investigation in awake behaving animals often employ methyl methacrylate (MMA) to serve as a bonding agent to secure the implant to the skull. Other designs rely on radially extending legs to secure the implant. Both of these methods have significant drawbacks. MMA is toxic to bone and frequently leads to infection while radially extending legs cause the skin to recede away from the implant, ultimately exposing bone and proliferating granulation tissue. Conclusions These radiolucent implants constitute a set of technologies suitable for reliable long-term recording, which minimize infection and tissue damage.

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Stimulation of the nucleus accumbens as behavioral reward in awake behaving monkeys

Cited by 20 publications

References 32 publications

Disturbance of approach‐avoidance behaviors in non‐human primates by stimulation of the limbic territories of basal ganglia and anterior insula

Disturbance of approach‐avoidance behaviors in non‐human primates by stimulation of the limbic territories of basal ganglia and anterior insula

Role of the Primate Ventral Tegmental Area in Reinforcement and Motivation

Custom-fit radiolucent cranial implants for neurophysiological recording and stimulation

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