Stimulation of the phagocytic function in guinea pig peritoneal macrophages by physical activity stress

Ortega, Eduardo; Collazos, M.E.; Barriga, C.; Fuente, Mónica De la

doi:10.1007/bf00636219

Cited by 46 publications

(28 citation statements)

References 21 publications

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“…Other results also support this idea with respect to chemotaxis. For example it has been observed that, after swimming until exhaustion, guinea-pig peritoneal macrophages showed an increased chemotactic capacity with a concomitant increase in plasma corticosterone concentration (Ortega et al 1992). In the present experiments, 0-72 ,smol 1I1 of corticosterone not only stimulated macrophage chemotaxis but also acted as a chemoattractant for these cells (see Fig.…”

Section: Discussionsupporting

confidence: 51%

Exercise‐induced stimulation of murine macrophage chemotaxis: role of corticosterone and prolactin as mediators.

Ortega

Forner

Barriga

1997

The Journal of Physiology

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1. Exercise provokes changes in the immune system, including macrophage activity. Chemotaxis is a necessary function of macrophages if they are to reach the focus of infection and strenuous acute exercise may modulate chemotaxis. However, the precise mechanisms remain unknown. 2. Three experiments were performed in the present study. (1) The effect of strenuous acute exercise (swimming until exhaustion) on the chemotactic capacity of macrophages was evaluated. (2) Peritoneal macrophages from control mice were incubated with plasma from exercised mice or control (no exercise) mice. The differences in the resulting chemotactic capacity were measured. (3) Changes in the concentration of plasma corticosterone and prolactin after exercise were also measured, and the effect of incubation with the post‐exercise levels of plasma corticosterone and prolactin on the chemotactic capacity of the peritoneal macrophages was then studied in vitro. 3. Exercise induced an increase in the macrophage chemotaxis index (103 +/‐ 8 vs. 47 +/‐ 11 in controls). Incubation with plasma from exercised mice led to an increased level of chemotaxis (68 +/‐ 18 vs. 40 +/‐ 6 with plasma from controls). Incubation with concentrations of corticosterone and prolactin similar to those observed in plasma immediately after exercise (corticosterone, 0.72 mumol l‐1; prolactin, 88 pmol l‐1) raised the chemotactic capacity with respect to that following incubation with the basal concentrations of the hormones in control animals (90 +/‐ 9 vs. 37 +/‐ 4 for corticosterone; 72 +/‐ 9 vs. 41 +/‐ 4 for prolactin). 4. It is concluded that corticosterone and prolactin may mediate the increased chemotaxis of peritoneal macrophages induced by exercise.

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Section: Discussionsupporting

confidence: 51%

Exercise‐induced stimulation of murine macrophage chemotaxis: role of corticosterone and prolactin as mediators.

Ortega

Forner

Barriga

1997

The Journal of Physiology

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“…Stress from noise can reduce release of superoxide ion and interleukin-1 from macrophages, whereas stress imposed by restraint or opioid dependency can produce reduction of "phagocytic activity (24)(25)(26). On the other hand, the stress of physical activity can actually enhance certain macrophage functions such as cytostatic activity, chemotaxis and phagocytosis (27,28). The potential mediator loop or loops that control these effects remain to be established.…”

Section: Molecular Biology Of Macrophage Activationmentioning

confidence: 96%

Molecular biology of macrophage activation: a pathway whereby psychosocial factors can potentially affect health.

Adams¹

1994

Psychosomatic Medicine

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Over the past decade, numerous links between the mind, the immune system, and the nervous system have been clearly elucidated in regard to the lymphoid elements of the immune system. Recently, attention has been given to the suggestion that such links exist to mononuclear phagocytes. The fundamental biology and physiology of these cells are clearly consonant with such a role. Mononuclear phagocytes bear receptors on their surface for numerous ligands, including neuroendocrine peptides and hormones. Furthermore, macrophages can be modulated by a variety of life-style choices such as smoking, ingestion of alcohol, and dietary lipid. Mononuclear phagocytes are key cells in the development of atherosclerosis and play significant roles in host protection against neoplasia and in the development of certain autoimmune diseases. In regard to atherogenesis, stress can potentiate the effects of a high lipid diet in initiating formation of the macrophage-laden lesions of early atherosclerosis. We have been able to show that oxidized lipids, acting in concert with stress as modeled pharmacologically in terms of catecholamines, induces a macrophage phenotype which would likely promote the development of atherosclerosis but lower host resistance to neoplasia. We are currently testing this hypothesis critically. Over the coming decade, it will be important for numerous investigators to examine the broad hypothesis that mononuclear phagocytes are one key element in the induction of psychosocially produced diseases. A clear understanding of the biology and molecular biology of these cells will provide a potent tool for analyzing these problems.

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“…Particle ingestion: Evaluated by the counts of the number of neutrophils ingesting at least one particle of latex and the number of particles inside 100 neutrophils after incubation at 37ºC on Kartell plates for 30 min of 200 µl of the dilution of the neutrophils in Hank liquid and the addition and re-incubation of 20 µl of latex to 1% in Hank, and the fixation and staining of plates (De La Fuente 1985;Ortega et al 1992). technique (1985), measuring by spectrophotometry at 525 nm of λ the reduction of nitroblue of tetrazolium to formazan by oxygenated compounds liberated by the neutrophil in samples stimulated by phagocytosis with latex particles (stimulated digestion) compared to others in which only Hank liquid (unstimulated digestion) had been added.…”

Section: Immunology Testsmentioning

confidence: 99%

Benefits of moderate training to the nonspecific immune response of colts

Escribano¹,

Agüera²,

Vivo³

et al. 2002

Equine Veterinary Journal

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SummaryThe aim of this work was to assess whether progressive training caused an improvement in the nonspecific immune response of colts because several unusual infections are due to defects inherent in the neutrophilic function among which respiratory diseases are a major defect in the performance of athletes taking part in professional sports activities. A group of 7 Anglo-Arabian colts belonging to the Army was selected. These animals carry out training programmes for their participation in National Jumping Competitions. During a submaximal exercise test (heart rate 150 beats/min and lactate levels maintained at aerobic-anaerobic threshold of 3 mmol/l), they were compared with 5 colts of the same breed, just beginning training exercises. Immediately after the test, the nonspecific immune capacity of neutrophilic polymorphonuclear cells was valued by adherence, chemotaxis, ingestion and digestion of foreign substances tests. The results showed significant differences between trained and nontrained animals for the adherence and foreign particle digestion tests and, beginning with a greater adherence in untrained animals, a superior effectiveness was achieved in the immune function in trained colts, whose digestive capactiy was increased with respect to the untrained ones. It was, therefore, concluded that moderate training and exercise improves and reinforces the response of the nonspecific immune system against future infections in the organisms.

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Stimulation of the phagocytic function in guinea pig peritoneal macrophages by physical activity stress

Cited by 46 publications

References 21 publications

Exercise‐induced stimulation of murine macrophage chemotaxis: role of corticosterone and prolactin as mediators.

Exercise‐induced stimulation of murine macrophage chemotaxis: role of corticosterone and prolactin as mediators.

Molecular biology of macrophage activation: a pathway whereby psychosocial factors can potentially affect health.

Benefits of moderate training to the nonspecific immune response of colts

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