Stimulation of the secretion of dehydroepiandrosterone by melatonin in mouse adrenals in vitro

Haus, Erhard; Nicolau, G Y; Ghinea, E; Dumitriu, L; Petrescu, E; Sackett-Lundeen, L

doi:10.1016/0024-3205(96)00079-3

Cited by 18 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our experiments, neither activation of the HPA-axis by rhu IL-1 injection nor physiologically elevated melatonin levels influence DHEA-S (and DHEA) concentrations in the serum of different mouse strains in vivo. These in vivo data are in contrast to data showing a stimulation of DHEA secretion by melatonin in murine adrenal cells in vitro [54].…”

Section: Discussioncontrasting

confidence: 83%

Altered Circadian Rhythms of the Stress Hormone and Melatonin Response in Lupus-prone MRL/MP-fasIpr Mice

Lechner

Dietrich

Santos

et al. 2000

Journal of Autoimmunity

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 83%

Altered Circadian Rhythms of the Stress Hormone and Melatonin Response in Lupus-prone MRL/MP-fasIpr Mice

Lechner

Dietrich

Santos

et al. 2000

Journal of Autoimmunity

View full text Add to dashboard Cite

“…DHEA was measured from the liquid media of cultured glands. The in vitro assay protocol, including dosage and time points, was chosen based on slight modifications of a previous protocol ( [40]; electronic supplementary material). Serum DHEA and CORT, DHEA and CORT content from adrenal gland homogenates, and DHEA in media were quantified using commercially available enzyme immunoassays (electronic supplementary material).…”

Section: (G) In Vitro Melatonin Administrationmentioning

confidence: 99%

The agonistic adrenal: melatonin elicits female aggression via regulation of adrenal androgens

et al. 2015

View full text Add to dashboard Cite

Classic findings have demonstrated an important role for sex steroids as regulators of aggression, but this relationship is lacking within some environmental contexts. In mammals and birds, the adrenal androgen dehydroepiandrosterone (DHEA), a non-gonadal precursor of biologically active steroids, has been linked to aggression. Although females, like males, use aggression when competing for limited resources, the mechanisms underlying female aggression remain understudied. Here, we propose a previously undescribed endocrine mechanism regulating female aggression via direct action of the pineal hormone melatonin on adrenal androgens. We examined this in a solitary hamster species, Phodopus sungorus, in which both sexes are highly territorial across the seasons, and display increased aggression concomitant with decreased serum levels of sex steroids in short 'winter-like' days. Short-but not long-day females had increased adrenal DHEA responsiveness co-occurring with morphological changes in the adrenal gland. Further, serum DHEA and total adrenal DHEA content were elevated in short days. Lastly, melatonin increased DHEA and aggression and stimulated DHEA release from cultured adrenals. Collectively, these findings demonstrate that DHEA is a key peripheral regulator of aggression and that melatonin coordinates a 'seasonal switch' from gonadal to adrenal regulation of aggression by direct action on the adrenal glands.

show abstract

“…Melatonin enhances microcirculatory structure and hence function in muscle,89 and also protects it from potentially damaging ischemic, oxidative stress‐related, and hormonal (eg, hyperthyroid) effects 89,90. Moreover, melatonin's stimulatory effects on other key substances, including DHEA,91 growth hormone (and consequently IGF‐1),92 and zinc93 may play an important role in protective and regenerative effects on both bone and muscle.…”

Section: The Revolution In Stem Cell and Regenerative Biology And Thementioning

confidence: 99%

From Molecular Biology to Anti‐aging Cognitive‐Behavioral Practices: The Pioneering Research of Walter Pierpaoli on the Pineal and Bone Marrow Foreshadows the Contemporary Revolution in Stem Cell and Regenerative Biology

Bushell

2005

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

Evidence is accruing that a cognitive‐behavioral regimen integrating cognitive techniques (meditation‐based anti‐stress, anti‐inflammatory techniques, others), dietary modification (“dietary restriction” or modified dietary restriction), and certain forms of aerobic exercise, may prolong the healthy life span in humans. Recent research has identified some of the likely molecular mediators of these potentially broad‐ranging, health‐enhancing and anti‐aging effects; these include DHEA, interleukins ‐10 and ‐4 (IL‐10, 1L‐4), and especially melatonin. Relatedly, what some are calling a revolution in biology and medicine has been emerging from research on stem cells and regeneration processes more generally. Dogma regarding limitations on the regenerative capacities of adult vertebrates is being cautiously yet enthusiastically revised in the wake of rapidly accumulating discoveries of more types of adult stem cells in mammals, including humans. For example, a recent review by D. Krause of Yale concluded that “in the [adult] bone marrow, in addition to hematopoietic stem cells and supportive stromal cells, there are cells with the potential to differentiate into mature cells of the heart, liver, kidney, lungs, GI tract, skin, bone, muscle, cartilage, fat, endothelium and brain” In addition, very recent studies have shown that DHEA, ILs‐10 and ‐4, and melatonin all possess potential regenerative, including stem cell‐activating, properties. More than a quarter of a century ago, Walter Pierpaoli initiated a series of extraordinary studies that demonstrated in experimental animals the potential for dramatic regeneration associated with changes in the pineal gland and bone marrow. This appeared to be not only retardation of aging, but also its reversal. Furthermore, as Pierpaoli was attempting to understand both anti‐aging regeneration and oncogenesis, he was focusing on both pro‐ and anti‐mitotic mechanisms: recent research now suggests that there is a nonpathologic, “healthy” form of regeneration that is actually antagonistic to oncogenesis, and that melatonin may be important in this form of regeneration. This paper explores Pierpaoli's pioneering studies in light of recent developments in stem cell and regenerative biology, particularly as related to the regenerative potential associated with certain cognitive‐behavioral practices, and includes evidence on this subject presented for the first time.

show abstract

Stimulation of the secretion of dehydroepiandrosterone by melatonin in mouse adrenals in vitro

Cited by 18 publications

References 8 publications

Altered Circadian Rhythms of the Stress Hormone and Melatonin Response in Lupus-prone MRL/MP-fasIpr Mice

Altered Circadian Rhythms of the Stress Hormone and Melatonin Response in Lupus-prone MRL/MP-fasIpr Mice

The agonistic adrenal: melatonin elicits female aggression via regulation of adrenal androgens

From Molecular Biology to Anti‐aging Cognitive‐Behavioral Practices: The Pioneering Research of Walter Pierpaoli on the Pineal and Bone Marrow Foreshadows the Contemporary Revolution in Stem Cell and Regenerative Biology

Contact Info

Product

Resources

About