2014
DOI: 10.1109/tnsre.2013.2267936
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Stimulation Selectivity of the “Thin-Film Longitudinal Intrafascicular Electrode” (tfLIFE) and the “Transverse Intrafascicular Multi-Channel Electrode” (TIME) in the Large Nerve Animal Model

Abstract: Neural prostheses are limited by the availability of peripheral neural electrodes to record the user's intention or provide sensory feedback through functional electrical stimulation. Our objective was to compare the ability of the novel “transverse intrafascicular multi-channel electrode” (TIME) and an earlier generation “thin-film longitudinal intrafascicular electrode” (tfLIFE) to selectively stimulate nerve fascicles and activate forelimb muscles in pigs. TIME was designed to access a larger subpopulation … Show more

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Cited by 67 publications
(62 citation statements)
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“…The tfLIFE and TIME (Boretius et al, 2010; Yoshida et al, 2000) are also both relatively simple to deploy and are less invasive and much more compliant (Badia et al, 2011b; Lago et al, 2007) than the Utah Slanted Electrode Array, but transverse deployment of the TIME across fascicles may limit the ability of fascicles to glide with respect to eachother (Millesi et al, 1990). Both the tfLIFE and the TIME have multiple contacts and therefore may provide access to discrete populations within a fascicle (Badia et al, 2011a; Badia et al, 2011b; Kundu et al, 2014), but the spatial distribution of the sites on each device is small and therefore the range of sensations and/or control sites may be limited. For applications that require access to distributed sites, the key concepts of the system described here (bundling of leads and a management system) could be adopted to facilitate the deployment of several tfLIFE or TIME devices.…”
Section: Discussionmentioning
confidence: 99%
“…The tfLIFE and TIME (Boretius et al, 2010; Yoshida et al, 2000) are also both relatively simple to deploy and are less invasive and much more compliant (Badia et al, 2011b; Lago et al, 2007) than the Utah Slanted Electrode Array, but transverse deployment of the TIME across fascicles may limit the ability of fascicles to glide with respect to eachother (Millesi et al, 1990). Both the tfLIFE and the TIME have multiple contacts and therefore may provide access to discrete populations within a fascicle (Badia et al, 2011a; Badia et al, 2011b; Kundu et al, 2014), but the spatial distribution of the sites on each device is small and therefore the range of sensations and/or control sites may be limited. For applications that require access to distributed sites, the key concepts of the system described here (bundling of leads and a management system) could be adopted to facilitate the deployment of several tfLIFE or TIME devices.…”
Section: Discussionmentioning
confidence: 99%
“…This intrafascicular placement of the neural interface can be accomplished by using punctate penetrating arrays such as the Utah Slanted Electrode Array (USEA) [3137], the transverse intrafascicular multichannel electrode array (TIME) [34,38], individual longitudinal intrafascicular electrodes (LIFEs) [32] or thin-film LIFEs [33,39]. Chronically implanted intrafascicular electrodes can elicit discrete activation of nerve fibers on electrical stimulation, as illustrated by reproducible and localized finger sensations or object discrimination capabilities in amputees [35,3740].…”
Section: Intrafascicular Electrodes: Stimulationmentioning
confidence: 99%
“…A sufficiently long length of the fascicle to accommodate the LIFE electrode is necessary. The somatotopic organization of peripheral nerves at both the fascicular and subfascicular levels allows highly selective functional and topographical access for stimulation or recording [31,33,40,4548]. The small diameter of LIFE electrodes, which are made of platinum/iridium (Pt/Ir), and their longitudinal orientation provide a safe and stable interface to the nerve subpopulations within a nerve fascicle [31,49].…”
Section: Intrafascicular Electrodes: Stimulationmentioning
confidence: 99%
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