Stimulation strategies for absence seizures: targeted therapy of the focus in coupled thalamocortical model

Wang, Zhihui; Wang, Qingyun

doi:10.1007/s11071-019-04876-z

Cited by 27 publications

(19 citation statements)

References 51 publications

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“…There are four types of neuronal populations shown in the original Taylor model [19], which are comprised of thalamic reticular nucleus (TRN) and specific relay nucleus (SRN) in the subcortical pathway and inhibitory interneuronal population (IN) and pyramidal neuronal population (PY) in the cortex, where pathological SWD activity is reproduced and a single pulse stimulation is given to control epileptic seizures. To explore how the cortico-cortical connectivities affected different macroscopic dynamical phenomena, some modified models were extended in spatial pathways [17,18,20,21].…”

Section: The Principle Of Connection and Schemes Of Treatmentmentioning

confidence: 99%

“…A set of evaluation indices is adopted to compare the advantages and disadvantages of the four strategies, especially indices on the percentage reduction in the number of absence seizures and energy consumption. The root mean 4 Neural Plasticity square (RMS) is considered to calculate the electrical current stimuli values of ICRS (t) and u ðtÞ defined as follows [20]:…”

Section: The Principle Of Connection and Schemes Of Treatmentmentioning

confidence: 99%

“…The original model containing four neurons in the space of brain has been proposed in [19]. The coupled thalamocortical model consisting of two different coupled compartments with short-range connection has been reported in [20]. A basal ganglia corticothalamic (BG-CT) model has been expanded via replacing basal ganglia by a 2I:3O feedback modulator [21].…”

Section: Introductionmentioning

confidence: 99%

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Regulatory Mechanism for Absence Seizures in Bidirectional Interactive Thalamocortical Model via Different Targeted Therapy Schemes

et al. 2021

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Recent clinical practice has found that the spike-wave discharge (SWD) scopes of absence seizures change from small cortical region to large thalamocortical networks, which has also been proved by theoretical simulation. The best biophysics explanation is that there are interactions between coupled cortico-thalamic and thalamocortical circuits. To agree with experiment results and describe the phenomena better, we constructed a coupled thalamocortical model with bidirectional channel (CTMBC) to account for the causes of absence seizures which are connected by the principle of two-way communication of neural pathways. By adjusting the coupling strength of bidirectional pathways, the spike-wave discharges are reproduced. Regulatory mechanism for absence seizures is further applied to CTMBC via four different targeted therapy schemes, such as deep brain stimulation (DBS), charge-balanced biphasic pulse (CBBP), coordinated reset stimulation (CRS) 1 : 0, and (CRS) 3 : 2. The new CTMBC model shows that neurodiversity in bidirectional interactive channel could supply theory reference for the bidirectional communication mode of thalamocortical networks and the hypothesis validation of pathogenesis.

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Section: The Principle Of Connection and Schemes Of Treatmentmentioning

confidence: 99%

Section: The Principle Of Connection and Schemes Of Treatmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Regulatory Mechanism for Absence Seizures in Bidirectional Interactive Thalamocortical Model via Different Targeted Therapy Schemes

et al. 2021

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“…Considering the side effect of single-pulse stimulation and DBS, here, we further explore the control effect of 3 : 2 CRS strategy on absence epilepsy, which is more effective and safer. The stimulus form is similar to the previous research [44], and the stimulation targets are TC and RE. In addition, in order to compare the effect of different stimulation strategies, we introduce two qualitative measurable indexes firstly.…”

Section: Control Of Coordinated Reset Stimulationmentioning

confidence: 99%

“…Ge et al presented a robust closed-loop control of SWD based on a thalamocortical computational model of absence epilepsy [43]. Wang et al tried different stimulation strategies, including deep brain stimulation (DBS), 1 : 0 coordinated reset stimulation (CRS), and 3 : 2 CRS [44]. These methods are all attempts based on theoretical models, but they can give some scientific enlightenments to the direction of clinical treatment.…”

Section: Introductionmentioning

confidence: 99%

Dynamic Transitions of Epilepsy Waveforms Induced by Astrocyte Dysfunction and Electrical Stimulation

et al. 2020

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Experimental studies have shown that astrocytes participate in epilepsy through inducing the release of glutamate. Meanwhile, considering the disinhibition circuit among inhibitory neuronal populations with different time scales and the feedforward inhibition connection from thalamic relay nucleus to cortical inhibitory neuronal population, here, we propose a modified thalamocortical field model to systematically investigate the mechanism of epilepsy. Firstly, our results show that rich firing activities can be induced by astrocyte dysfunction, including high or low saturated state, high- or low-frequency clonic, spike-wave discharge (SWD), and tonic. More importantly, with the enhancement of feedforward inhibition connection, SWD and tonic oscillations will disappear. In other words, all these pathological waveforms can be suppressed or eliminated. Then, we explore the control effects after different external stimulations applying to thalamic neuronal population. We find that single-pulse stimulation can not only suppress but also induce pathological firing patterns, such as SWD, tonic, and clonic oscillations. And we further verify that deep brain stimulation can control absence epilepsy by regulating the amplitude and pulse width of stimulation. In addition, based on our modified model, 3 : 2 coordinated reset stimulation strategies with different intensities are compared and a more effective and safer stimulation mode is proposed. Our conclusions are expected to give more theoretical insights into the treatment of epilepsy.

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Control of epileptic activities in a cortex network of multiple coupled neural populations under electromagnetic induction

Sun

Liu

Yang

et al. 2023

Appl. Math. Mech.-Engl. Ed.

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Epilepsy is believed to be associated with the abnormal synchronous neuronal activity in the brain, which results from large groups or circuits of neurons. In this paper, we choose to focus on the temporal lobe epilepsy, and establish a cortex network of multiple coupled neural populations to explore the epileptic activities under electromagnetic induction. We demonstrate that the epileptic activities can be controlled and modulated by electromagnetic induction and coupling among regions. In certain regions, these two types of control are observed to show exactly reverse effects. The results show that the strong electromagnetic induction is conducive to eliminating the epileptic seizures. The coupling among regions has a conduction effect that the previous normal background activity of the region gives way to the epileptic discharge, owing to coupling with spike wave discharge regions. Overall, these results highlight the role of electromagnetic induction and coupling among the regions in controlling and modulating epileptic activities, and might provide novel insights into the treatments of epilepsy.

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Stimulation strategies for absence seizures: targeted therapy of the focus in coupled thalamocortical model

Cited by 27 publications

References 51 publications

Regulatory Mechanism for Absence Seizures in Bidirectional Interactive Thalamocortical Model via Different Targeted Therapy Schemes

Regulatory Mechanism for Absence Seizures in Bidirectional Interactive Thalamocortical Model via Different Targeted Therapy Schemes

Dynamic Transitions of Epilepsy Waveforms Induced by Astrocyte Dysfunction and Electrical Stimulation

Control of epileptic activities in a cortex network of multiple coupled neural populations under electromagnetic induction

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