Stimulative effects of<i>Polygonum amplexicaule</i>var.<i>sinense</i>on osteoblastic MC3T3-E1 cells

Xiang, Ming; Su, Hexiu; Hu, Jinyue; Yan, Yunjun

doi:10.3109/13880209.2011.568507

Cited by 12 publications

(9 citation statements)

References 24 publications

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“…), and the extract of Polygonum amplexicaule var. sinense showed the stimulative effect on osteoblasts by influencing cell cycle progression, which was consistent with the findings in the present study. ,− …”

Section: Resultssupporting

confidence: 92%

Characterizations and the Mechanism Underlying Osteogenic Activity of Peptides from Enzymatic Hydrolysates of Stichopus japonicus

Yang

et al. 2021

J. Agric. Food Chem.

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Sea cucumber (Stichopus japonicus) is a kind of fishery product with high nutritional value. It exhibits a wide range of biological activity and has potential application in the food, pharmaceutical, and biomedical industries. However, there are no reports available on the effects of S. japonicus peptides (SJP) on bone mineral density regulations. The purpose of this work was to analyze the composition and osteogenic activity of SJP and explore its underlying mechanism. The results showed that SJP stimulated cell proliferation, differentiation, and mineralization in a dose-dependent manner. In addition, SJP could promote the proliferation of MC3T3-E1 cells by altering the cell cycle progression and regulating the expression of Cyclins. Besides, SJP activated the WNT/β-catenin pathway and increased the nuclear level of the active form β-catenin. Furthermore, SJP also induced the expression of bone morphogenetic protein (BMP-2) and increase the phosphorylation levels of p38, JNK, and ERK, suggesting that the osteogenic activity of SJP may be achieved through the activation of WNT/β-catenin and BMP/MAPK signal pathways. In vivo, SJP significantly inhibited the serum levels of RANKL, ALP, and TRAP, whereas it increased the levels of osteocalcin and osteoprotegerin in OVX-mice. These results indicate that SJP may have the potential to stimulate bone formation and regeneration, and may be used as a functional food or nutritional supplement to prevent osteoporosis.

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Section: Resultssupporting

confidence: 92%

Characterizations and the Mechanism Underlying Osteogenic Activity of Peptides from Enzymatic Hydrolysates of Stichopus japonicus

Yang

et al. 2021

J. Agric. Food Chem.

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“…CHMs may exhibit bone protection effect after longterm treatment. Studies have also suggested that CHM may be beneficial for bone metabolism through osteopenia prevention, anti-osteoporotic activities, promotion of fracture healing, and inhibition of inflammation (Chow et al, 1982;Chen et al, 2005;Li et al, 2011;Ma et al, 2011;Xiang et al, 2011;Wong et al, 2013;He and Shen, 2014;Zhang et al, 2016;Hsiao et al, 2017;Wang et al, 2018b;Xi et al, 2018;Lee et al, 2019). Among these studies, there were two review studies reported in human beings.…”

Section: Discussionmentioning

confidence: 99%

“…Chinese herbal medicines (CHMs) are often used to treat bone related diseases, as they show anti-inflammatory, antiosteopenia, anti-osteoporotic, and promote fracture healing activities (Chow et al, 1982;Chen et al, 2005;Li et al, 2011;Ma et al, 2011;Xiang et al, 2011;Shih et al, 2012;Wong et al, 2013;He and Shen, 2014;Mukwaya et al, 2014;Lin et al, 2015;Zhang et al, 2016;Hsiao et al, 2017;Wang et al, 2018b;Xi et al, 2018;Cheng et al, 2019a;Cheng et al, 2019b). However, none of these studies have been carried out in prospective randomized clinical trials in humans.…”

Section: Introductionmentioning

confidence: 99%

Chinese Herbal Medicine Usage Reduces Overall Mortality in HIV-Infected Patients With Osteoporosis or Fractures

et al. 2021

Front. Pharmacol.

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The survival of patients with HIV has greatly improved, due to Anti-Retroviral Therapy (ART). However, long-term HIV survivors often develop serious bone abnormalities, possibly due to the interplay of osteoblasts, osteoclasts, HIV ad ART. We evaluated in a nation-wide study in Taiwan the effect of Chinese herbal medicine (CHM) on overall mortality in HIV patients with osteoporosis or fractures. Enrollment period was between 1998 and 2011. Patients with osteoporosis or fractures before the HIV infection, and those with less than 14 days CHM use, were excluded. This left 498 patients, 160 CHM users, 338 without CHM. Univariate Kaplan-Meier and multivariate Cox regression analysis were used to compare the overall mortality in these 2 groups. Due to the nature of Chinese medicine, CHMs inevitably varied. We therefore also used rule mining and network analysis to determine which major CHM clusters were prescribed to the patients. CHM users had a much Lower mortality (hazard ratio (HR) = 0.43, 95% confidence interval (CI): 0.24–0.77, p < 0.005) and higher survival (p = 0.004, log-rank test). Although the CHMs greatly varied, network analysis identified one main cluster of strongly related CHM combinations (Chuan-Xiong-Cha-Tiao-San (CXCTS), Gan-Cao (GC; Glycyrrhiza uralensis Fisch.), Liu-He-Tang (LHT), Huang-Qin-Tang (HQT), Jia-Wei-Ping-Wei-San (JWPWS), and Dang-Gui-Long-Hui-Wan (DGLHuiW)). CHM as an additional treatment strongly improves overall survival in HIV-infected patients with osteoporosis and fractures.

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“…As CHM is cost-effective with relatively few side effects and has been widely applied for clinical use in Asian countries, it has been previously used for the clinical treatment of osteoporosis and bone fracture in Taiwan (Shih et al, 2012; Liao et al, 2015). Indeed, there are several Chinese herbs that help maintain bone health by regulating bone metabolism (Chow et al, 1982; Chen et al, 2005; Li et al, 2011; Ma et al, 2011; Xiang et al, 2011; Wong et al, 2013; He and Shen, 2014; Zhang et al, 2016; Hsiao et al, 2017; Wang et al, 2018c; Xi et al, 2018). Our pharmacoepidemiologic results have demonstrated that for the patients who were above 60 years old, there was a significant distribution difference in the cumulative overall mortality between CHM and non-CHM users ( Table S3 and Table S4 ).…”

Section: Resultsmentioning

confidence: 99%

“…CHM has also been used to treat bone-related diseases including osteoporosis and bone fractures (Shih et al, 2012; Mukwaya et al, 2014; Liao et al, 2015). CHM is believed to maintain bone health, including: inhibition of inflammation, promotion of fracture healing, osteopenia prevention, and antiosteoporotic activities (Chow et al, 1982; Chen et al, 2005; Li et al, 2011; Ma et al, 2011; Xiang et al, 2011; Wong et al, 2013; He and Shen, 2014; Zhang et al, 2016; Hsiao et al, 2017; Wang et al, 2018c; Xi et al, 2018; Lee et al, 2019). These studies have encouraged the search for complementary therapy for the better management of bone-related diseases.…”

Section: Introductionmentioning

confidence: 99%

Effects of Chinese Herbal Medicines on the Risk of Overall Mortality, Readmission, and Reoperation in Hip Fracture Patients

et al. 2019

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Hip fracture is a major public health concern, with high incidence rates in the elderly worldwide. Hip fractures are associated with increased medical costs, patient dependency on families, and higher rates of morbidity and mortality. Chinese herbal medicine (CHM) is typically characterized as cost-effective and suitable for long-term use with few side effects. To better understand the effects of CHM on hip fracture patients, we utilized a population-based database to investigate the demographic characteristics, cumulative incidence of overall mortality, readmission, reoperation, and patterns of CHM prescription. We found that CHM usage was associated with a lower risk of overall mortality [ P = 0.0009; adjusted hazard ratio (HR): 0.47, 95% confidence interval (CI): 0.30–0.73], readmission ( P = 0.0345; adjusted HR: 0.67, 95% CI: 0.46–0.97), and reoperation ( P = 0.0009; adjusted HR: 0.57, 95% CI: 0.40–0.79) after adjustment for age, type of hip fracture, surgical treatment type, and comorbidities. We also identified the herbal formulas, single herbs, and prescription patterns for the treatment of hip fracture by using association rule mining and network analysis. For hip fracture patients, the most common CHM coprescription pattern was Du-Zhong (DZ) → Xu-Duan (XD), followed by Du-Huo-Ji-Sheng-Tang (DHJST) → Shu-Jing-Huo-Xue-Tang (SJHXT), and Gu-Sui-Bu (GSB) → Xu-Duan (XD). Furthermore, XD was the core prescription, and DZ, GSB, SJHXT, and DHJST were important prescriptions located in cluster 1 of the prescription patterns. This study provides evidence for clinical CHM use as an adjunctive therapy that offers benefits to hip fracture patients.

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Stimulative effects ofPolygonum amplexicaulevar.sinenseon osteoblastic MC3T3-E1 cells

Cited by 12 publications

References 24 publications

Characterizations and the Mechanism Underlying Osteogenic Activity of Peptides from Enzymatic Hydrolysates of Stichopus japonicus

Characterizations and the Mechanism Underlying Osteogenic Activity of Peptides from Enzymatic Hydrolysates of Stichopus japonicus

Chinese Herbal Medicine Usage Reduces Overall Mortality in HIV-Infected Patients With Osteoporosis or Fractures

Effects of Chinese Herbal Medicines on the Risk of Overall Mortality, Readmission, and Reoperation in Hip Fracture Patients

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