Stimulatory Action of Itopride Hydrochloride on Colonic Motor Activity in Vitro and in Vivo

Tsubouchi, Tadashi; Saito, Takaharu; Mizutani, Fujie; Yamauchi, Toshie; Iwanaga, Yuji

doi:10.1124/jpet.102.048603

Cited by 48 publications

(44 citation statements)

References 21 publications

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“…On the other hand, itopride hydrochloride is a benzamide derivative and acts through both dopamine D2 receptor antagonism and acetylcholinesterase inhibition. Previous studies have revealed that itopride hydrochloride stimulates the colonic peristalsis with propelling colonic luminal contents [18, 19]. …”

Section: Introductionmentioning

confidence: 99%

Efficacy of Prokinetic Agents in Improving Bowel Preparation for Colonoscopy

Mishima

Amano²,

Okita³

et al. 2008

Digestion

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Background and Aim: Colonoscopy plays an important role in the diagnosis and treatment of gastrointestinal illness in both Western countries and Japan. However, preparative bowel cleansing for colonoscopy is frequently troublesome for elderly and/or constipated patients, since they must drink larger volumes of lavage solution for adequate cleansing. We investigated the use of prokinetic agents for improving the efficacy and tolerability of bowel cleansing prior to colonoscopy. Methods: 613 patients were divided into two groups according to oral lavage solution used (polyethylene glycol or magnesium citrate), and were further randomized to receive either vehicle (100 ml water) alone, vehicle with 5 mg mosapride citrate, or vehicle with 50 mg itopride hydrochloride 30 min before administration of lavage solution. Experimental parameters included bowel cleansing quality, times to first defecation and completion of bowel cleansing, and incidence of uncomfortable abdominal symptoms during colonoscopy preparation. Results: Administration of mosapride citrate or itopride hydrochloride prior to oral lavage solution did not significantly improve bowel cleansing quality. However, statistically significantly fewer uncomfortable abdominal symptoms were found in patients who received mosapride citrate or itopride hydrochloride versus vehicle alone. Conclusion: Prokinetic agents effectively decreased the incidence of uncomfortable abdominal symptoms experienced during colonoscopy preparation.

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Section: Introductionmentioning

confidence: 99%

Efficacy of Prokinetic Agents in Improving Bowel Preparation for Colonoscopy

Mishima

Amano²,

Okita³

et al. 2008

Digestion

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“…Mosapride did not affect the colonic motor index in conscious dogs, and showed a relatively high EC50 value, indicating low affinity for the distal colon in guinea pig (Mine et al, 1997). In the isolated guinea pig colon, mosapride augmented only segmental contraction in the proximal portion, and failed to induce peristaltic acceleration (Tsubouchi et al, 2003). However, mosapride increased the amplitude of proximal colonic motility in conscious guinea pigs, measured by a force transducer recording contractions of the circular muscle of the proximal colon (Inui et al, 2002).…”

Section: The Effect Of 5-ht4 Receptor Agonists On Colonic Motor Functionmentioning

confidence: 95%

5-Hydroxytryptamine4 receptor agonists and colonic motility

Kim

2009

J. Smooth Muscle Res.

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5-Hydroxytryptamine (5-HT) released from enterochromaffin cells regulates gastrointestinal function in either an excitatory or inhibitory manner. 5-HT3 and 5-HT4 receptors in the gut have been the focus of clinical studies on the management of gastrointestinal motility disorders. 5-HT stimulates intestinal propulsive reflexes through 5-HT4 receptors. 5-HT4 receptor agonists can stimulate upper or lower gut motility, depending on their selectivity and affinity. In the guinea pig colon, the distribution of 5-HT4 receptors in the myenteric plexus and circular muscle layer differs between the proximal and distal regions. 5-HT stimulates intestinal motility via excitatory neurons while causing relaxation of the circular muscle via 5-HT4 receptors. In the light of these findings on the distribution of 5-HT4 receptors, the effects of receptor agonist compounds could vary depending on the species of experimental animal and the anatomical region studied.

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“…На сегодняшний день получены экспериментальные данные о стимулирующем влиянии итоприда на моторику кишечника [63]. Представляется перспективным приме-нение итоприда гидрохлорида у пациентов с хрониче-ским дуоденитом и явлениями дуоденостаза [64,65].…”

Section: результаты многочисленных международных и российских исследоunclassified

Functional Gastrointestinal Disorders: Select From the Point Prokinetic Comorbidity, Clinical Efficacy and Drug Safety

Трухан¹

2017

Med. sov.

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Д.И. ТРУХАН, д.м.н., профессор, Омский государственный медицинский университет Минздрава России ФУНКЦИОНАЛЬНЫЕ ГАСТРОИНТЕСТИНАЛЬНЫЕ РАССТРОЙСТВА:ВЫБОР ПРОКИНЕТИКА С ПОЗИЦИЙ КОМОРБИДНОСТИ, КЛИНИЧЕСКОЙ ЭФФЕКТИВНОСТИ И ЛЕКАРСТВЕННОЙ БЕЗОПАСНОСТИ Функциональные гастроинтестинальные расстройства в настоящее время рассматриваются как наиболее распространен-ная патология желудочно-кишечного тракта (ЖКТ). Симптомы, которые могут быть отнесены к гастродуоденальной обла-сти, представляют собой одну из основных подгрупп среди функциональных желудочно-кишечных расстройств, в которой синдром функциональной диспепсии (ФД) по праву сохраняет ведущие позиции. Патогенетическим фактором ФД и дру-гих функциональных гастроинтестинальных расстройств (ФГИР), который можно считать доказанным в настоящее время, являются нарушения моторики ЖКТ, что определяет целесообразность использования в базисной терапии этих заболева-ний лекарственных препаратов, воздействующих на моторную функцию ЖКТ и препятствующих антиперистальтическим сокращениям гладкой мускулатуры, которые объединены в группу прокинетиков. С позиций коморбидности, клинической эффективности и лекарственной безопасности итоприда гидрохлорид является приоритетным прокинетиком в лечении ФД и других сопутствующих ФГИР.Ключевые слова: функциональные гастроинтестинальные расстройства, функциональная диспепсия, гастроэзофагеаль-ная рефлюксная болезнь, прокинетики, итоприда гидрохлорид, Итопра®. D.I. TRUKHAN, MD, PhD, Federal State Educational Institution of Higher Education «Omsk state medical university» Ministry for Public Health of the Russian Federation FUNCTIONAL GASTROINTESTINAL DISORDERS: SELECT FROM THE POINT PROKINETIC COMORBIDITY, CLINICAL EFFICACY AND DRUG SAFETY

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Stimulatory Action of Itopride Hydrochloride on Colonic Motor Activity in Vitro and in Vivo

Abstract: We investigated the effects of itopride hydrochloride (itopride,

Cited by 48 publications

References 21 publications

Efficacy of Prokinetic Agents in Improving Bowel Preparation for Colonoscopy

Efficacy of Prokinetic Agents in Improving Bowel Preparation for Colonoscopy

5-Hydroxytryptamine4 receptor agonists and colonic motility

Functional Gastrointestinal Disorders: Select From the Point Prokinetic Comorbidity, Clinical Efficacy and Drug Safety

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