Stimulatory effect of Crocus sativus (saffron) on β2-adrenoceptors of guinea pig tracheal chains

Nemati, H.; Boskabady, Mohammad Hossein; Vostakolaei, H. Ahmadzadef

doi:10.1016/j.phymed.2008.07.008

Cited by 55 publications

(34 citation statements)

References 30 publications

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“…The hydro-ethanolic extract of C. sativus (saffron) and one of its constituents, safranal, exerted a stimulatory effect on β 2 -adrenoceptors of the tracheal smooth muscles of guinea pigs, indicating its relatively potent stimulatory effect on β 2 -adrenoceptors, which can be partially attributed to its constituent, safranal (Nemati et al, 2008).…”

Section: Stimulatory Effect On β 2 -Adrenoceptorsmentioning

confidence: 99%

A review of the relaxant effect of various medicinal plants on tracheal smooth muscle, their possible mechanism(s) and potency

Shakeri

Boskabady

2015

Journal of Ethnopharmacology

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Section: Stimulatory Effect On β 2 -Adrenoceptorsmentioning

confidence: 99%

A review of the relaxant effect of various medicinal plants on tracheal smooth muscle, their possible mechanism(s) and potency

Shakeri

Boskabady

2015

Journal of Ethnopharmacology

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“…Safranal has been shown to possess various pharmacological activities, including antioxidant [21], anticonvulsant [22], anti-anxiety and antidepressant [8], antitussive [23], antinociceptive [24], and anti-ischemia [25] activities. Safranal has also been shown to be able to improve impaired memory and learning ability in rats [26].…”

Section: Introductionmentioning

confidence: 99%

The Relaxant Activity of Safranal in Isolated Rat Aortas is Mediated Predominantly via an Endothelium-Independent Mechanism - Vasodilatory mechanism of safranal -

Razavi

Amanloo

Imenshahidi

et al. 2016

Journal of Pharmacopuncture

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Objectives:Safranal is a pharmacologically active component of saffron and is responsible for the unique aroma of saffron. The hypotensive effect of safranal has been shown in previous studies. This study evaluates the mechanism for the vasodilatory effects induced by safranal on isolated rat aortas.Methods:To study the vasodilatory effects of safranal (0.2, 0.4 and 0.8 mM), we contracted isolated rat thoracic aorta rings by using 10-6-M phenylephrine (PE) or 80-mM KCl. Dimethyl sulfoxide (DMSO) was used as a control. The vasodilatory effect of safranal was also evaluated both on intact and denuded endothelium aortic rings. Furthermore, to study the role of nitric oxide and prostacyclin in the relaxation induced by safranal, we incubated the aortic rings by using L-NAME (10-6 M) or indomethacin (10-5 M), each for 20 minutes.Results:Safranal induced relaxation in endothelium-intact aortic rings precontracted by using PE or KCl in a concentration-dependent manner, with a maximum relaxation of more than 100%. The relaxant activity of safranal was not eliminated by incubating the aortic rings with L-NAME (EC50 = 0.29 vs. EC50 = 0.43) or with indomethacin (EC50 = 0.29 vs. EC50 = 0.35), where EC50 is the half maximal effective concentration. Also, the vasodilatory activity of safranal was not modified by endothelial removal.Conclusion:This study indicated that relaxant activity of safranal is mediated predominantly through an endothelium- independent mechanism.

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“…Moreover, saffron stigma has been used as a drug in folk medicine since ancient times for various purposes such as an aphrodisiac, antispasmodic, andexpectorant, antidepressant, and stomachic agent (Abdullaev, 1993;Richelson, 1994;Wang et al, 2010). In some folk remedies, it was also used against scarlet fever, smallpox, colds, asthma, eye, and heart diseases (Rios et al, 1996;Abdullaev and EspinosaAguirre, 2004;Carmona et al, 2007;Nemati et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Chemical constituents and bioactivities of the liposoluble fraction from different medicinal parts ofCrocus sativus

Zheng¹,

Li²,

Ma³

et al. 2011

Pharmaceutical Biology

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Stimulatory effect of Crocus sativus (saffron) on β2-adrenoceptors of guinea pig tracheal chains

Cited by 55 publications

References 30 publications

A review of the relaxant effect of various medicinal plants on tracheal smooth muscle, their possible mechanism(s) and potency

A review of the relaxant effect of various medicinal plants on tracheal smooth muscle, their possible mechanism(s) and potency

The Relaxant Activity of Safranal in Isolated Rat Aortas is Mediated Predominantly via an Endothelium-Independent Mechanism - Vasodilatory mechanism of safranal -

Chemical constituents and bioactivities of the liposoluble fraction from different medicinal parts ofCrocus sativus

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