Stimulatory effect of Holy basil and Thai basil on mouse spleen cell proliferation

Biswas, Aparna Riti; Mason, Lindee; Mortuza, Asif; Blumenthal, Elliott; Mustafa, Ahmed

doi:10.1080/15321819.2020.1862864

Cited by 6 publications

(5 citation statements)

References 22 publications

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“…4) as macrophage phagocytic capacity, but the stress (66%) and stress basil (65%) treatments are significantly lower than the control (100%). Holy basil has been previously shown to improve spleen cell proliferation in mice (Biswas et al 2021), but that was not observed here in fish. Fulton's condition factor also shows similar results (Fig.…”

Section: Resultscontrasting

confidence: 59%

Effects of Holy Basil (Ocimum Sanctum Linnaeus) On the Modulation Of Stress in Nile Tilapia (Oreochromis Niloticus Linnaeus)

Biswas

Mason

Mustafa

2023

J. Biodivers. Conserv. Bioresour. Manag.

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Fish in aquaculture face stress, which is a major concern due to its effects on the overall wellbeing of the fish. To modulate the stress responses, researchers are turning to the use nutraceuticals rather than chemical drugs. In a six-week long study, holy basil (Ocimum sanctum) was used to observe its effects on stress in Nile tilapia (Oreochromis niloticus). Stress was induced by adding cortisol with the feed as a supplement. Three different treatments (control, stress, stress- basil), each with two replicates, were used to measure serum cortisol, lysozyme activity, macrophage phagocytosis, spleen somatic index, and condition factor. Basil had no significant effect on any of the parameters when comparing the stress and stress basil treatments. But the result showed significant imperative effect of stress due to cortisol supplement in both stress and stress-basil groups. The results suggest that basil may have potentials to modulate the stress response in Nile tilapia. J. Biodivers. Conserv. Bioresour. Manag. 2022, 8(2): 1-12

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Section: Resultscontrasting

confidence: 59%

Effects of Holy Basil (Ocimum Sanctum Linnaeus) On the Modulation Of Stress in Nile Tilapia (Oreochromis Niloticus Linnaeus)

Biswas

Mason

Mustafa

2023

J. Biodivers. Conserv. Bioresour. Manag.

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“…Recent studies showed that darkly pigmented fruits such as berry extract could decelerate the aging process, alleviate hypertension and cardiovascular diseases, stress modulation, and improve protection against infectious agents [1-3, 13, 14]. Although several attempts have been made by researchers to distinguish the role of various nutraceuticals in different model systems [2,[15][16][17], the comprehensive insights of the nutraceutical are yet to be uncovered due to inadequate studies in various models, limited knowledge about the potential effect of processing techniques specifically extract preparation and enrichment, and lack of data regarding bioavailability and membrane interaction [2,[18][19][20]. Thus, to explicate the specific role of nutraceuticals on immune response, we investigated the effect of 13% anthocyanin standardized Austrian black elderberry (Sambucus nigra 'Haschberg') extract in cell-mediated and humoral immunity in in-vitro conditions using Nile tilapia, Oreochromis niloticus.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the role of anthocyanin standardized elderberry (Sambucus nigra) extract as an immune-stimulating nutraceutical of Nile tilapia, Oreochromis niloticus

et al. 2022

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The study of nutraceuticals and their connection to immunity is an expanding field of research. The use of nutraceuticals to alleviate stress and enhance immunity in adverse aquaculture environments have been examined to a certain extent. To elucidate the understanding, we focused on the immunological effect of membrane-separated 13% anthocyanin standardized elderberry (EB) extract with maltodextrin excipient, widely used first-line nutraceuticals to augment the immunity, in aquaculture fish, Nile tilapia. To evaluate the potential of EB-extract, we assessed their capability to enhance lymphocyte proliferation and interleukin-2 production in an in-vitro condition using spleen and thymus lymphocytes. The experiments on spleen and thymus T-cells demonstrated significantly higher T-cell proliferation by EB-extract when lectin mitogen Con A was present as a stimulator. Likewise, our spleen B-cell proliferation result reveals a significant effect of EB-extracts, along with B-cell stimulator non-lectin mitogen LPS. Further, the quantification of IL-2 indicates elevated IL-2 levels when spleen T-cells were cultured with EB-extracts and with Con A present as a stimulator. These suggest that 13% anthocyanin standardized EB-extracts can aggrandize fish cells’ cellular and humoral immune responses. With further research, elderberry extracts could be used to supplement commercial feed in aquaculture to reduce stress and stimulate the immune response.

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“…Among the hop phytochemicals, xanthohumol has been reported to cause a marked reduction in nitric oxide (NO) synthesis through the inhibition of nitric oxide synthase (iNOS) [18]; it also blocked the production of inflammatory mediators in LPS-and IFN-γ-activated macrophages by suppressing the activation of NF-κB, STAT-1α and IRF-1 cascades [81]. Furthermore, several polyphenols detected in the ECP and HOP extracts, including chicoric acid, caffeic acid, ferulic acid and benzoic acid derivatives, as well as resveratrol, catechin and thymol, have been reported to act as immune system modulators, owing to their antioxidant power [82][83][84][85][86][87].…”

Section: Discussionmentioning

confidence: 99%

ECHOPvir: A Mixture of Echinacea and Hop Extracts Endowed with Cytoprotective, Immunomodulatory and Antiviral Properties

Percaccio,

De Angelis,

Acquaviva

et al. 2023

Nutrients

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Respiratory viral infections continue to pose significant challenges, particularly for more susceptible and immunocompromised individuals. Nutraceutical strategies have been proposed as promising strategies to mitigate their impact and improve public health. In the present study, we developed a mixture of two hydroalcoholic extracts from the aerial parts of Echinacea purpurea (L.) Moench (ECP) and the cones of Humulus lupulus L. (HOP) that can be harnessed in the prevention and treatment of viral respiratory diseases. The ECP/HOP mixture (named ECHOPvir) was characterized for the antioxidant and cytoprotective properties in airway cells. Moreover, the immunomodulating properties of the mixture in murine macrophages against antioxidant and inflammatory stimuli and its antiviral efficacy against the PR8/H1N1 influenza virus were assayed. The modulation of the Nrf2 was also investigated as a mechanistic hypothesis. The ECP/HOP mixture showed a promising multitarget bioactivity profile, with combined cytoprotective, antioxidant, immunomodulating and antiviral activities, likely due to the peculiar phytocomplexes of both ECP and HOP, and often potentiated the effect of the single extracts. The Nrf2 activation seemed to trigger these cytoprotective properties and suggest a possible usefulness in counteracting the damage caused by different stressors, including viral infection. Further studies may strengthen the interest in this product and underpin its future nutraceutical applications.

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Stimulatory effect of Holy basil and Thai basil on mouse spleen cell proliferation

Cited by 6 publications

References 22 publications

Effects of Holy Basil (Ocimum Sanctum Linnaeus) On the Modulation Of Stress in Nile Tilapia (Oreochromis Niloticus Linnaeus)

Effects of Holy Basil (Ocimum Sanctum Linnaeus) On the Modulation Of Stress in Nile Tilapia (Oreochromis Niloticus Linnaeus)

Assessment of the role of anthocyanin standardized elderberry (Sambucus nigra) extract as an immune-stimulating nutraceutical of Nile tilapia, Oreochromis niloticus

ECHOPvir: A Mixture of Echinacea and Hop Extracts Endowed with Cytoprotective, Immunomodulatory and Antiviral Properties

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