Stimulatory Effects of Prostaglandin E2 on Neurogenesis in the Dentate Gyrus of the Adult Rat

Uchida, Katsuya; Kumihashi, Kentarou; Kurosawa, Satoshi; Kobayashi, Tetsuya; Itoi, Keiichi; Machida, Takeo

doi:10.2108/zsj.19.1211

Cited by 54 publications

(30 citation statements)

References 30 publications

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“…Direct infusion of a stable analog of prostaglandin E 2 into the hippocampus increases cell proliferation in the dentate gyrus of the hippocampus and these cells express a neural marker suggesting prostaglandin E 2 has stimulatory effects on the hippocampal neurogenesis. 45) Other reports examined the effect of COX-2 inhibitor on ischemia-induced neurogenesis in the dentate gyrus of the hippocampus. 46,47) Treatment with COX-2 inhibitor after ischemia inhibited enhancement of neural progenitor proliferation, indicating that COX-2 products play a role in the proliferation of neural cells after ischemia.…”

Section: Possible Roles Of Ecs-induced Cox-2 In Hippocampusmentioning

confidence: 99%

Exploration of New Molecular Mechanisms for Antidepressant Actions of Electroconvulsive Seizure

Segi-Nishida

2011

Biological & Pharmaceutical Bulletin

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Electroconvulsive seizure (ECS) therapy is a clinically proven treatment for depression and is often effective even in patients resistant to chemical antidepressants. However, the molecular mechanisms underlying the therapeutic efficacy of ECS are not fully understood. Here, I review studies that show molecular, cellular, and behavioral changes by ECS treatment, and discuss the functions of ECS to underlie the action of antidepressant effects. In hippocampus, these changes cover gene induction, increased adult neurogenesis, and electrophysiological reactivity. Especially, the role of vascular endothelial growth factor (VEGF) in neurogenesis is discussed. Among other gene expression changes in hippocampus, a role of cyclooxygenase (COX)-2, an inducible type of the rate-limiting enzyme of prostanoid synthesis, is focused. ECS-induced changes in other brain regions such as prefrontal cortex and hypothalamus, and ECS-induced behavioral changes are also reviewed. Understanding the molecular, cellular, and behavioral changes by ECS will provide a new view to find potential targets for novel antidepressant design that are highlighted by these findings.

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Section: Possible Roles Of Ecs-induced Cox-2 In Hippocampusmentioning

confidence: 99%

Exploration of New Molecular Mechanisms for Antidepressant Actions of Electroconvulsive Seizure

Segi-Nishida

2011

Biological & Pharmaceutical Bulletin

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“…Arachidonic acid metabolite and prostaglandin E2 play an important role in neurogenesis (Uchida et al, 2002). Zhao et al (2009) have reported that maternal arachidonic acid supplementation improves neurodevelopment in young adult offspring from rat dams with and without diabetes.…”

Section: Discussionmentioning

confidence: 99%

Alterations of the Giant Pyramidal Neurons (Betz Cells) in Brain Cortex of Rat Offspring Born from Gestational Diabetic Dams: A Morphometric Study

Ghafari

Golalipour

2015

Int. J. Morphol.

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GHAFARI, S.; GOLALIPOUR, E. & GOLALIPOUR, M. J.Alterations of the giant pyramidal neurons (Betz cells) in brain cortex of rat offspring born from gestational diabetics dams: a morphometric study. Int. J. Morphol., 33(3):1120-1125, 2015. SUMMARY:A few studies reported the adverse effects of gestational diabetes on hippocampus and spinal cord of rat offspring. Giant pyramidal neurons are giant pyramidal neurons located in fifth layers of the gray matter in the primary motor cortex. Therefore, this study was conducted to determine the effect of gestational diabetes on the giant pyramidal neurons and the thickness of internal pyramidal layer in the brain cortex of rat offspring. On day 1 of gestation, 10 Wistar rat dams were randomly allocated into two control and diabetic groups. Five animals in diabetic group received 40 mg/kg/BW of Streptozotocin (intraperitoneally) and control animals received normal saline. We randomly selected six offspring of every subject in both groups at day 28, 56 and 84. Rat offspring were scarified and then coronal sections were taken from the right brain cortex and sections were stained with Cresyl violet. The density of giant pyramidal neurons in brain cortex and thickness of internal pyramidal layer of brain cortex were evaluated. In P28, P56, P84 the Betz cells density of brain cortex were significantly reduced from 107.6±6.2, 131.6±4.6 and 143.5±4.0 in controls to 84.96±2.1, 109.8±7.3 and 121.05±5.6 in cases (p<0.05), respectively. The thickness of the internal pyramidal layer of brain cortex in P28, 56 and P84 was significantly higher in gestational diabetic group in comparison with the control group (p<0.05). This study showed that uncontrolled gestational diabetes reduces the giant pyramidal neurons density and internal pyramidal layer thickness in brain cortex of rat offspring.

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“…De fato, inúmeros estudos em modelos experimentais in vitro sugerem a contribuição potencial de enzimas PLA 2 e seus metabólitos ácido araquidônico e lisofosfatidilcolina para a neurogênese, incluindo sobrevivência e diferenciação neuronal em ambos, processo neurodesenvolvimental e resposta a dano neuronal (Tabela 3) [86][87][88][89][90][91][92][93][94] . Além disso, estudos em modelos experimentais in vitro sugerem que a via de metabolismo do ácido araquidônico pela 5-lipoxigenase desempenha um papel crucial na proliferação de progenitores neurais, pelo menos durante o processo neurodesenvolvimental 95,96 , e estudos em modelos animais in vivo sugerem que a via de metabolismo do ácido araquidônico pela ciclooxigenase-2 desempenha um papel importante na proliferação de progenitores neurais em ambos, animais selvagens e modelos animais de neurodegeneração adultos, e na diferenciação em neurônios imaturos e maduros, pelo menos em animais selvagens adultos (Tabela 3) 97,98 . Estudos adicionais são necessários para investigar a relação direta entre a PLA 2 (ou seus metabólitos) e o processo de neurogênese em animais adultos, incluindo modelos animais de DA.…”

Section: Discussionunclassified

“…O envolvimento da ciclo-oxigenase-2 e da prostaglandina E 2 na neurogênese tem sido descrito no cérebro de roedores adultos. Inicialmente, foi relatado que a infusão de um análogo da prostaglandina E 2 no hipocampo de ratos adultos aumentou a proliferação celular na SGZ; as células proliferativas também expressaram o marcador de diferenciação celular PSA-NCAM e o marcador de neurônios maduros NeuN 97 . Posteriormente, foi observado que o tratamento de camundongos adultos com inibidores da ciclo-oxigenase-2 mascarou o aumento da proliferação de progenitores neurais no giro denteado induzido por isquemia cerebral global.…”

Section: Possível Participação Da Fosfolipase a 2 Na Neurogênese Promunclassified

Enriquecimento ambiental como estratégia para promover a neurogênese na doença de Alzheimer: possível participação da fosfolipase A2

Schaeffer¹

2010

Rev. psiquiatr. clín.

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Stimulatory Effects of Prostaglandin E2 on Neurogenesis in the Dentate Gyrus of the Adult Rat

Cited by 54 publications

References 30 publications

Exploration of New Molecular Mechanisms for Antidepressant Actions of Electroconvulsive Seizure

Exploration of New Molecular Mechanisms for Antidepressant Actions of Electroconvulsive Seizure

Alterations of the Giant Pyramidal Neurons (Betz Cells) in Brain Cortex of Rat Offspring Born from Gestational Diabetic Dams: A Morphometric Study

Enriquecimento ambiental como estratégia para promover a neurogênese na doença de Alzheimer: possível participação da fosfolipase A2

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