Stimuli-Induced Release of Compounds from Elastin Biomimetic Matrix

Bandiera, Antonella; Markulin, A; Corich, Lucia; Vita, Francesca; Borelli, Violetta

doi:10.1021/bm401677n

Cited by 26 publications

(32 citation statements)

References 45 publications

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“…The enzymatic degradation of ELP assemblies for drug release can be preferentially targeted to regions with increased elastase activity, which often correlate with pathological conditions such as pulmonary emphysema, cystic fibrosis, bacterial infections, inflammation, chronic wounds and atherosclerosis . In support, a stable ELP hydrogel demonstrated enhanced drug release when exposed to elastolytic activity from Pseudomonas aeruginosa and from activated human polymorphonuclear leukocytes …”

Section: Elastin‐like Peptide (Elp) Constructsmentioning

confidence: 98%

Fabricated Elastin

Yeo

Aghaei-Ghareh-Bolagh

Brackenreg

et al. 2015

Adv Healthcare Materials

103

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The mechanical stability, elasticity, inherent bioactivity, and self-assembly properties of elastin make it a highly attractive candidate for the fabrication of versatile biomaterials. The ability to engineer specific peptide sequences derived from elastin allows for precise control of these physicochemical and organizational characteristics, and further broadens the diversity of elastin-based applications. Elastin and elastin-like peptides can also be modified or blended with other natural or synthetic moieties, including peptides, proteins, polysaccharides and polymers, to augment existing capabilities or confer additional architectural and biofunctional features to compositionally pure materials. Elastin and elastin-based composites have been subjected to diverse fabrication processes, including heating, electrospinning, wet spinning, solvent casting, freeze-drying, and cross-linking, for the manufacture of particles, fibers, gels, tubes, sheets and films. The resulting materials can be tailored to possess specific strength, elasticity, morphology, topography, porosity, wettability, surface charge and bioactivity. This extraordinary tunability of elastin-based constructs enables their use in a range of biomedical and tissue engineering applications such as targeted drug delivery, cell encapsulation, vascular repair, nerve regeneration, wound healing, and dermal, cartilage, bone and dental replacement.

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Section: Elastin‐like Peptide (Elp) Constructsmentioning

confidence: 98%

Fabricated Elastin

Yeo

Aghaei-Ghareh-Bolagh

Brackenreg

et al. 2015

Adv Healthcare Materials

103

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“…For example, Bandiera et al engineered proteolytically-responsive scaffolds for delivery of model proteins using elastin-derived biomimetic peptides of recombinant origin. 36 Incorporation of Controlled-release Technology: Growth factors and other compounds such as antibiotics 37 have been incorporated into scaffold/matrix designs for a variety of purposes. For example, controlled release systems can entail bulk incorporation of growth factors into the scaffold matrix by adsorption or chemical coupling, 38 incorporation of delivery drug-laden vehicles/carriers, such as microspheres, into the scaffold matrix, 39 or surface functionalization of the ECM proteins with moieties that have high growth factor binding affinities, for example heparin sulfates in the case of VEGFs and FGFs.…”

Section: Ecm-inspired Smart Matrix Designmentioning

confidence: 99%

Smart Matrices for Distal Lung Tissue Engineering

Mondrinos¹,

Lelkes²

2015

Stem Cells, Tissue Engineering and Regenerative Medicine

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“…In this sense, Bandiera [73] has described the behavior of different cell lines cultured on surfaces coated with an ELR that adopts a defined pattern of concentric circles. The good adhesiveness displayed by all the cell lines studied is noteworthy, with the specific behavior depending on the cell type concerned.…”

Section: Modification Of Surface Topography By Elrsmentioning

confidence: 99%

Recent Contributions of Elastin-Like Recombinamers to Biomedicine and Nanotechnology

Arias¹,

Santos²,

Fernández‐Colino³

et al. 2014

CTMC

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Abstract:The emergence of the new scientific field known as nanomedicine is being catalyzed by multiple improvements in nanoscience techniques and significant progress in materials science, especially as regards the testing of novel and sophisticated biomaterials. This conjuncture has furthered the development of promising instruments in terms of detection, bioanalysis, therapy, diagnostics and imaging. Some of the most innovative new biomaterials are protein-inspired biomimetic materials in which modern biotechnology and genetic-engineering techniques complement the huge amount of information afforded by natural protein evolution to create advanced and tailor-made multifunctional molecules. Amongst these protein-based biomaterials, Elastin-like Recombinamers (ELRs) have demonstrated their enormous potential in the fields of biomedicine and nanoscience in the last few years. This broad applicability derives from their unmatched properties, particularly their recombinant and tailor-made nature, the intrinsic characteristics derived from their elastin-based origin (mainly their mechanical properties and ability to self-assemble as a result of their stimuli-responsive behavior), their proven biocompatibility and biodegradability, as well as their versatility as regards incorporating advanced chemical or recombinant modifications into the original structure that open up an almost unlimited number of multifunctional possibilities in this developing field. This article provides an updated review of the recent challenges overcome by using these recombinant biomaterials in the fields of nano-and biomedicine, ranging from nanoscale applications in surface modifications and self-assembled nanostructures to drug delivery and regenerative medicine.

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Stimuli-Induced Release of Compounds from Elastin Biomimetic Matrix

Cited by 26 publications

References 45 publications

Fabricated Elastin

Fabricated Elastin

Smart Matrices for Distal Lung Tissue Engineering

Recent Contributions of Elastin-Like Recombinamers to Biomedicine and Nanotechnology

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