Stimuli responsive biopolymer (chitosan) based blend hydrogels for wound healing application

Rasool, Atta; Ata, Sadia; Islam, Atif

doi:10.1016/j.carbpol.2018.09.083

Cited by 181 publications

(86 citation statements)

References 39 publications

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“…Other advantages of PVP in FFSs are high hygroscopicity, good biocompatibility, and the ability to increase bioadhesive strength, which is probably explained by the formation of hydrogen bonds and Van der Walls’ forces [89,90]. Therefore, PVP was investigated in various studies on wound dressing applications [44,93,94,95,96,97,98]. In some cases, the copolymer of polyvinylpyrrolidone-vinyl acetate is used instead of PVP [32].…”

Section: Formulation Design Of Controlled Drug Release Film-forminmentioning

confidence: 99%

Controlled Release Film Forming Systems in Drug Delivery: The Potential for Efficient Drug Delivery

Tran

2019

Pharmaceutics

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Despite many available approaches for transdermal drug delivery, patient compliance and drug targeting at the desired concentration are still concerns for effective therapies. Precise and efficient film-forming systems provide great potential for controlling drug delivery through the skin with the combined advantages of films and hydrogels. The associated disadvantages of both systems (films and hydrogels) will be overcome in film-forming systems. Different strategies have been designed to control drug release through the skin, including changes to film-forming polymers, plasticizers, additives or even model drugs in formulations. In the current review, we aim to discuss the recent advances in film-forming systems to provide the principles and review the methods of these systems as applied to controlled drug release. Advances in the design of film-forming systems open a new generation of these systems.

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Section: Formulation Design Of Controlled Drug Release Film-forminmentioning

confidence: 99%

Controlled Release Film Forming Systems in Drug Delivery: The Potential for Efficient Drug Delivery

Tran

2019

Pharmaceutics

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“…Fibroblasts play a critical role in normal wound healing 45 . Furthermore, the outer hydrogel of the IS can absorb and retain wound exudate, and promote the proliferation of fibroblasts and consequently the formation of wound epithelium 46 , 47 . Compared with the control and PD5 groups, the amount of deposited collagen in the IS group initially increased and then decreased.…”

Section: Resultsmentioning

confidence: 99%

3D printed intelligent scaffold prevents recurrence and distal metastasis of breast cancer

et al. 2020

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Rationale: Tumors are commonly treated by resection, which usually leads to massive hemorrhage and tumor cell residues, thereby increasing the risk of local recurrence and distant metastasis. Methods: Herein, an intelligent 3D-printed poly(lactic-co-glycolic acid), gelatin, and chitosan scaffold loaded with anti-cancer drugs was prepared that showed hemostatic function and good pH sensitivity. Results: Following in situ implantation in wounds, the scaffolds absorbed hemorrhage and cell residues after surgery, and promoted wound healing. In an in vivo environment, the scaffold responded to the slightly acidic environment of the tumor to undergo sustained drug release to significantly inhibit the recurrence and growth of the tumor, and reduced drug toxicity, all without causing damage to healthy tissues and with good biocompatibility. Conclusions: The multifunctional intelligent scaffold represents an excellent treatment modality for breast cancer following resection, and provides great potential for efficient cancer therapy.

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“…The pH-responsive hydrogel made of chitosan and poly( N -vinyl-2-pyrrolidone) in the presence of 74% neutralized PAA was used for wound healing. It showed different extent of swelling depending on the pH of external media [63]. The pH-responsive character of chitosan hydrogels was imparted on textile fabric by coating or integrating on it to develop smart textiles or medical textiles [50,64].…”

Section: Natural Stimuli-responsive Polymersmentioning

confidence: 99%

Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application

2019

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This review describes some commercially available stimuli-responsive polymers of natural and synthetic origin, and their applications in drug delivery and textiles. The polymers of natural origin such as chitosan, cellulose, albumin, and gelatin are found to show both thermo-responsive and pH-responsive properties and these features of the biopolymers impart sensitivity to act differently under different temperatures and pH conditions. The stimuli-responsive characters of these natural polymers have been discussed in the review, and their respective applications in drug delivery and textile especially for textile-based transdermal therapy have been emphasized. Some practically important thermo-responsive polymers such as pluronic F127 (PF127) and poly(N-isopropylacrylamide) (pNIPAAm) of synthetic origin have been discussed in the review and they are of great importance commercially because of their in situ gel formation capacity. Some pH-responsive synthetic polymers have been discussed depending on their surface charge, and their drug delivery and textile applications have been discussed in this review. The selected stimuli-responsive polymers of synthetic origin are commercially available. Above all, the applications of bio-based or synthetic stimuli-responsive polymers in textile-based transdermal therapy are given special regard apart from their general drug delivery applications. A special insight has been given for stimuli-responsive hydrogel drug delivery systems for textile-based transdermal therapy, which is critical for the treatment of skin disease atopic dermatitis.

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Stimuli responsive biopolymer (chitosan) based blend hydrogels for wound healing application

Cited by 181 publications

References 39 publications

Controlled Release Film Forming Systems in Drug Delivery: The Potential for Efficient Drug Delivery

Controlled Release Film Forming Systems in Drug Delivery: The Potential for Efficient Drug Delivery

3D printed intelligent scaffold prevents recurrence and distal metastasis of breast cancer

Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application

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