Stimuli‐Responsive Cucurbit[n]uril‐Mediated Host‐Guest Complexes on Surfaces

Wiemann, Maike; Jonkheijm, Pascal

doi:10.1002/ijch.201700109

Cited by 23 publications

(21 citation statements)

References 115 publications

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“…For example, most of the complicated supramolecular architectures, such as rotaxanes, catenanes, molecular shuttles, molecular switches, molecular machines, supramolecular polymers, supramolecular amphiphiles, and so on, are based on the host−guest chemistry of these macrocycles. They have been also employed to modify the surface properties of metal nanoparticles via noncovalent host−guest interactions, covering their applications in drug delivery, highly sensitive sensors, selective catalysis, and so on.…”

Section: Introductionmentioning

confidence: 99%

Supramolecular‐Macrocycle‐Based Crystalline Organic Materials

et al. 2019

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macrocycles. They have been also employed to modify the surface properties of metal nanoparticles via noncovalent host−guest interactions, [31] covering their applications in drug delivery, [32] highly sensitive sensors, [33] selective catalysis, [34] and so on.In addition to their intensive applications based on their host−guest chemistry, macrocycles have also been used as building blocks to construct solid materials including porous organic polymers (POPs), [35,36] metal-organic frameworks (MOFs), [37][38][39][40][41][42][43] and crystalline organic materials (COMs). [44][45][46][47][48][49][50][51][52][53][54][55][56][57] Particular attention should be paid to COMs, a class of organic materials featuring facile preparation, high crystallinity, structural diversity, chemical stability, solution-processability, etc. [58][59][60][61][62][63][64][65][66][67][68][69][70] Different from MOFs that are composed of both inorganic (metal ions) and organic species (organic ligands) through coordination, COMs refer to a kind of crystalline materials composed of pure organics connected by either covalent or noncovalent bonds. [71][72][73] For COMs connected by noncovalent bonds, the typical materials are organic molecular crystals with intriguing properties such as semiconductor, [53] porosity, [68] etc. Owing to the inefficient packing of organic building blocks in the crystal state, some molecular crystals display extrinsic porosity, which are often termed as hydrogen-bonded organic frameworks (HOFs) [74,75] or supramolecular organic frameworks (SOFs). [76][77][78][79][80] For COMs connected by covalent bonds, typical materials are crystalline covalent organic frameworks (COFs), which were firstly reported in 2005 by Yaghi and co-workers [44] Benefitting from rigid chemical bonds and building blocks, COFs show permanent and well-ordered porosity. [45][46][47][48] Supramolecular-macrocycle-based COMs, a class of COMs with macrocycles as the main building blocks, have drawn particular attention in recent years. According to their components, supramolecular-macrocycle-based COMs can be classified into two main categories, the ones composed of pure macrocycles and the others consisting of macrocycles and other simple organic building blocks. Owing to their prefabricated cavities of a certain type, some of macrocycle-based COMs exhibit intrinsic microporosity for guest adsorption in the solid state. On the other hand, the extrinsic porosity of some macrocyclebased COMs may form due to the inefficient packing of these rigid macrocyclic molecules in the crystalline state. In certain circumstances, both intrinsic and extrinsic microporosity can be created in a single lattice of a certain COM, thus leading to Supramolecular macrocycles are well known as guest receptors in supramolecular chemistry, especially host−guest chemistry. In addition to their wide applications in host−guest chemistry and related areas, macrocycles have also been employed to construct crystalline organic materials (COMs) owing to their particular structur...

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Section: Introductionmentioning

confidence: 99%

Supramolecular‐Macrocycle‐Based Crystalline Organic Materials

et al. 2019

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“…84 Modification of biosensors by CB[n] anchoring offers new opportunities to generate stimulusresponsive surfaces in a reversible manner. 85 Up to date, two examples of CB[n]-functionalized surfaces as analytical tools for prostate and breast cancer diagnostics have been reported. In 2016, F. Zhang and co-workers developed an electrochemical sensing platform on the basis of a CB [7]-modified electrode for the detection of breast cancer susceptibility gene (BRCA) DNA (Scheme 7a).…”

Section: Cb-assisted Supramolecular Sensing and Imagingmentioning

confidence: 99%

Cucurbiturils in nucleic acids research

Chernikova

Berdnikova

2020

Chem. Commun.

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“…CB[ n ]s are widely employed in catalysis, drug delivery, nanoparticle functionalization, supramolecular chemistry, and in mediating different chemical reactions [68–73]. In terms of its usage in 129 Xe NMR and MRI, there are few reports in which they have been successfully used for different applications.…”

Section: Synthetic Nanosystems For Hypercest Applicationsmentioning

confidence: 99%

Nanoparticle-Based Contrast Agents for¹²⁹Xe HyperCEST NMR and MRI Applications

Jayapaul

Schröder

2019

Contrast Media & Molecular Imaging

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Spin hyperpolarization techniques have enabled important advancements in preclinical and clinical MRI applications to overcome the intrinsic low sensitivity of nuclear magnetic resonance. Functionalized xenon biosensors represent one of these approaches. They combine two amplification strategies, namely, spin exchange optical pumping (SEOP) and chemical exchange saturation transfer (CEST). The latter one requires host structures that reversibly bind the hyperpolarized noble gas. Different nanoparticle approaches have been implemented and have enabled molecular MRI with 129Xe at unprecedented sensitivity. This review gives an overview of the Xe biosensor concept, particularly how different nanoparticles address various critical aspects of gas binding and exchange, spectral dispersion for multiplexing, and targeted reporter delivery. As this concept is emerging into preclinical applications, comprehensive sensor design will be indispensable in translating the outstanding sensitivity potential into biomedical molecular imaging applications.

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Stimuli‐Responsive Cucurbit[n]uril‐Mediated Host‐Guest Complexes on Surfaces

Cited by 23 publications

References 115 publications

Supramolecular‐Macrocycle‐Based Crystalline Organic Materials

Supramolecular‐Macrocycle‐Based Crystalline Organic Materials

Cucurbiturils in nucleic acids research

Nanoparticle-Based Contrast Agents for¹²⁹Xe HyperCEST NMR and MRI Applications

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Stimuli‐Responsive Cucurbit[n]uril‐Mediated Host‐Guest Complexes on Surfaces

Cited by 23 publications

References 115 publications

Supramolecular‐Macrocycle‐Based Crystalline Organic Materials

Supramolecular‐Macrocycle‐Based Crystalline Organic Materials

Cucurbiturils in nucleic acids research

Nanoparticle-Based Contrast Agents for129Xe HyperCEST NMR and MRI Applications

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Nanoparticle-Based Contrast Agents for¹²⁹Xe HyperCEST NMR and MRI Applications