Stimuli-responsive DOX release behavior of cross-linked poly(acrylic acid) nanoparticles

Abstract

Cross-linked poly(acrylic acid) nanoparticles were synthesized via distillation precipitation polymerization of acrylic acid and ethylene glycol dimethacrylate withdifferent molar ratios. Spherical nanoparticles with diameters between 75 and 122 nm were synthesized and exhibited temperature and pH-responsive behaviors. However, this behavior was less pronounced for samples with higher cross-linking degrees. The potential of all nanoparticles as carriers for controlled release of doxorubicin (DOX) anti-cancer drug was examined at pH values of 1.2, 5.3 and 7.4. An obvious alleviation in burst release behavior and the amount of cumulative drug release was seen for all nanoparticles as the pH of the medium and the cross-linking degree of nanoparticle increased. Also kinetics of drug release was studied using mathematical models of zero-order, first-order, Higuchi, Korsmeyer-Peppas and Hixson-Crowell, where Higuchi and Korsmeyer-Peppas models best defined the kinetics of drug release.

Fabrication of acid‐labile poly(2‐hydroxyethyl methacrylate) nanoparticles using aldazine‐based crosslinker as pH‐sensitive drug nanocarriers

“…Hence, homogeneous solution (at the beginning of the reaction) induced phase separation in later stages, and this phenomenon resulted in nucleation and formation of the primary particles. The formed particles were swollen by the solvent and then polymerization was continued within the individual particles to form larger particles, whereas single growing radical chains may be isolated from others 43,44 . Actually, MBA was assumed as a hydrophilic crosslinking agent and, therefore, particle core was swelled in significant amount of solution.…”

Enhancing the Kinetic Stability of Polymeric Nanomicelles (PLGA) Using Nano-Montmorillonite for Effective Targeting of Cancer Tumors

“…The most important outcome of enhancing the stability of NDDS is the extension of the release period of drug molecule . The release period of curcumin from PMC and PC NPs was compared using a dialysis assay.…”

“…The release mechanism of curcumin from PMC and PC was investigated by fitting the release data to the mathematical models of zero order (eq ), first order (eq ), Hixson–Crowell (eq ), and Korsmeyer–Peppas (eq ) using the equations below where Q 0 is the initial amount of drug, Q t is the cumulative amount of drug at the time t , K 0 is zero-order release constant, K is first-order release constant, K HC is Hixson-Crowell release constant, F is fraction of drug released at the time t , M t is the amount of drug released at the time t , M is the total amount of drug in dosage form, K m is the kinetic constant, and t n is diffusion or release exponent. − …”

Multifunctional and stimuli-responsive nanocarriers for targeted therapeutic delivery

“…Lower burst release of doxorubicin (change in hydrodynamic diameter) was observed with increase in the cross-linker content and pH of the release medium. pH-sensitive behavior of this PAA nanoparticle systems with higher and lower cross-linking ratios has been shown schematically in Figure 5 [ 128 ].…”

“… Responses of the poly(acrylic acid) (PAA) nanoparticles with different monomer to cross-linker ratios to pH and temperature. Reproduced with permission [ 128 ]. The change in hydrodynamic diameter and drug release from high and low cross-linked PAA has been displayed schematically.…”