Stimuli-responsive hybrid cluster bombs of PEGylated chitosan encapsulated DOX-loaded superparamagnetic nanoparticles enabling tumor-specific disassembly for on-demand drug delivery and enhanced MR imaging

Xie, Pengwei; Du, Pengcheng; Li, Jiagen; Liu, Peng

doi:10.1016/j.carbpol.2018.10.076

Cited by 39 publications

(16 citation statements)

References 29 publications

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“…PEGylated, CS-encapsulated, DOX-loaded oleylamine-modified Fe 3 O 4 (DOX/OA-Fe 3 O 4 @CS-PEG) NPs, as cancer-specific theranostics for targeted DOX delivery and magnetic resonance (MR) imaging, designed by Xie et al, had a high drug loading capacity of 24.3% and a saturation magnetization of 4.11 emu/g. The results of the in vitro evaluation showed that the empty NC was cytocompatible, while DOX/OA-Fe 3 O 4 @CS-PEG increased penetration into the nuclei of HepG2 and showed higher efficacy in comparison to free DOX [166]. The NC for GRQD and Fe 3 O 4 , conjugated with concanavalin A, a lectin protein, provided GRQD-ConA@Fe 3 O 4 .…”

Section: Figure 11mentioning

confidence: 99%

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Graphenic Materials for Biomedical Applications

2019

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Graphene-based nanomaterials have been intensively studied for their properties, modifications, and application potential. Biomedical applications are one of the main directions of research in this field. This review summarizes the research results which were obtained in the last two years (2017-2019), especially those related to drug/gene/protein delivery systems and materials with antimicrobial properties. Due to the large number of studies in the area of carbon nanomaterials, attention here is focused only on 2D structures, i.e. graphene, graphene oxide, and reduced graphene oxide.

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Section: Figure 11mentioning

confidence: 99%

“…increased penetration into the nuclei of HepG2 and showed higher efficacy in comparison to free DOX [166]. The NC for GRQD and Fe3O4, conjugated with concanavalin A, a lectin protein, provided GRQD-ConA@Fe3O4.…”

Section: Figure 11mentioning

confidence: 99%

Graphenic Materials for Biomedical Applications

2019

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“…Controlled anticancer drug release [142] Tumor targeted therapy [143] N-octyl-O-sulfate chitosan Self-assembled polymeric micelles Absorption enhancement of anticancer drug [144,145] Tumor targeted therapy [146][147][148] Increasing stability of drug loaded liposomes [149] 2-[phenylhydrazine (or hydrazine)-thiosemicarbazone]-chitosan Powder Pharmaceutical and food industries [150] (Ser-Ile-Lys-Val-Ala-Val) peptide-modified chitosan Hydrogel Skin substitutes for wound closure in mice [53,151] Galactosylated chitosan (GC) NPs Tumor targeted therapy [152][153][154][155] siRNA delivery [156,157] N-palmitoyl chitosan (NPCS) MPs and micelles Tumor targeted therapy [158,159] O-palmitoyl chitosan (OPC) Liposomes Intestinal drug delivery [160] Hydroxyapatite/CS NPs Drug delivery [161][162][163][164] CS loaded with antioxidant NPs Hydrogel Drug release [165] PEGylated CS NPs Tumor targeted therapy [166][167][168] Chitosan-based vaccine Polyelectrolyte, NPs Intranasal CS-DNA vaccine [169,170] 4. Conclusions CS, as a natural polymer, is actively used in tissue engineering and regenerative medicine as a biomaterial alone, as well as in combination with other polymers.…”

Section: Cs/derivativesmentioning

confidence: 99%

Progress in the Development of Chitosan-Based Biomaterials for Tissue Engineering and Regenerative Medicine

et al. 2019

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Over the last few decades, chitosan has become a good candidate for tissue engineering applications. Derived from chitin, chitosan is a unique natural polysaccharide with outstanding properties in line with excellent biodegradability, biocompatibility, and antimicrobial activity. Due to the presence of free amine groups in its backbone chain, chitosan could be further chemically modified to possess additional functional properties useful for the development of different biomaterials in regenerative medicine. In the current review, we will highlight the progress made in the development of chitosan-containing bioscaffolds, such as gels, sponges, films, and fibers, and their possible applications in tissue repair and regeneration, as well as the use of chitosan as a component for drug delivery applications.

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“…Natural polymers play an important role in surface engineering of nanoparticles, which have been widely applied in catalysis, 35,36 environment, 37 drug delivery, 38 and biomedical 39−42 fields. Nanoparticles modified with natural polymers often possess stimuli-responsive property, and act as multifunctional carriers for constructing smart drug delivery systems.…”

Section: Introductionmentioning

confidence: 99%

Carboxymethyl Chitosan Modified Carbon Nanoparticle for Controlled Emamectin Benzoate Delivery: Improved Solubility, pH-Responsive Release, and Sustainable Pest Control

Song

Wang

Xie

et al. 2019

ACS Appl. Mater. Interfaces

143

129

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Environmentally friendly pesticide delivery systems have drawn extensive attention in recent years, and they show great promise in sustainable development of agriculture. We herein report a multifunctional nanoplatform, carboxymethyl chitosan modified carbon nanoparticles (CMC@CNP), as the carrier for emamectin benzoate (EB, a widely used insecticide), and investigate its sustainable antipest activity. EB was loaded on CMC@CNP nanocarrier via simple physisorption process, with a high loading ratio of 55.56%. The EB@CMC@CNP nanoformulation showed improved solubility and dispersion stability in aqueous solution, which is of vital importance to its practical application. Different from free EB, EB@CMC@CNP exhibited pH-responsive controlled release performance, leading to sustained and steady EB release and prolonged persistence time. In addition, the significantly enhanced anti-UV property of EB@ CMC@CNP further ensured its antipest activity. Therefore, EB@CMC@CNP exhibited superior pest control performance than free EB. In consideration of its low cost, easy preparation, free of organic solution, and enhanced bioactivity, we expect, CMC@CNP will have a brilliant future in pest control and green agriculture.

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Stimuli-responsive hybrid cluster bombs of PEGylated chitosan encapsulated DOX-loaded superparamagnetic nanoparticles enabling tumor-specific disassembly for on-demand drug delivery and enhanced MR imaging

Cited by 39 publications

References 29 publications

Graphenic Materials for Biomedical Applications

Graphenic Materials for Biomedical Applications

Progress in the Development of Chitosan-Based Biomaterials for Tissue Engineering and Regenerative Medicine

Carboxymethyl Chitosan Modified Carbon Nanoparticle for Controlled Emamectin Benzoate Delivery: Improved Solubility, pH-Responsive Release, and Sustainable Pest Control

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