Stimuli-responsive hybrid metal nanocomposite – A promising technology for effective anticancer therapy

Biogenic synthesis of copper oxide nanoparticles: comprehensive in vitro profiling for cervical cancer treatment and antibacterial strategies

“…This phenomenon amplifies their efficacy and renders them appropriate for an extensive range of biological applications. 62,64,65 The prepared NPs were subjected to various characterizations, such as UV-vis spectroscopy, FTIR, XRD, zeta potential, SEM, EDS, and TEM, and were also evaluated for their potential as an anticancer, antibacterial, and photocatalytic nanomaterial, and the results are reported as follows.…”

pH-responsive chitosan/acrylamide/gold/nanocomposite supported with silver nanoparticles for controlled release of anticancer drug

“…Cancer is a difficult and stubborn disease to treat that claims many lives. More than ten million cases are discovered annually around the world 1 . There are numerous cancer treatments available, but their side effects on healthy organs are numerous and sometimes fatal 2 .…”

“…Researchers' efforts have focused on producing a new safe anti-cancer drug or strategy. Therefore, efforts focused on the production of biopolymer composites that can be extrinsically or internally induced and coupled (stimuli-response) with nanometer-sized materials and with an anti-cancer drug 1 , 10 , 11 . Polymers containing ionizable functional groups can be used in the production of pH stimuli-response polymers (SRP) 12 .…”

“…Metal nanocomposite drug delivery is based on the concept of turning on/off bioactive compounds such as drugs, genes, and succession to specific tissues or organs through a stimulus such as heat, radiation, or pH change 9 . The pH-responsive nanocomposites or stimuli-responsive nanocomposites (SRNs) are one of the most successful and effective designs in the drug transport and delivery process, as the infected cells are acidic at a pH of 5 to 6.5 while healthy cells are at 7.4 neutral environments 1 , 3 . Loading the inorganic Nano materials onto the polymers enhances their stability, and efficiency facilitates drug release at the target site 13 , 14 , and prolongs blood circulation time in vivo.…”