Stimuli-Responsive Hydrogels in Drug Delivery

Rodríguez‐Rodríguez, Rogelio; Espinosa‐Andrews, Hugo; García-Carvajal, Zaira Y.

doi:10.1007/978-981-16-7152-4_3

Cited by 5 publications

(9 citation statements)

References 163 publications

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“…However, injectable hydrogels are not only all those that gel once they have been injected into the human body. Hydrogels with shear-thinning and self-healing properties are also classified as injectable biomaterials [ 23 , 77 , 78 ].…”

Section: Hydrogel Scaffolds Used In the Regeneration Of The Nervous S...mentioning

confidence: 99%

“…Hydrogels produced in situ undergo a transition from a solution to a gel state, triggered by stimuli such as temperature, pH, or irradiation [ 91 , 92 ]. They can incorporate primary cells, stem cells, growth factors, and differentiating factors in situ in the matrix during the transition, leading to the formation of a three-dimensional (3D) scaffold for tissue engineering applications [ 23 , 93 ]. Other systems undergo gelation/solidification when the temperature decreases or have an inverse gelling property characterized by a lower critical solution temperature.…”

Section: Hydrogel Scaffolds Used In the Regeneration Of The Nervous S...mentioning

confidence: 99%

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Injectable Hydrogels for Nervous Tissue Repair—A Brief Review

Politrón-Zepeda,

Fletes-Vargas,

Rodríguez-Rodríguez

2024

Gels

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The repair of nervous tissue is a critical research field in tissue engineering because of the degenerative process in the injured nervous system. In this review, we summarize the progress of injectable hydrogels using in vitro and in vivo studies for the regeneration and repair of nervous tissue. Traditional treatments have not been favorable for patients, as they are invasive and inefficient; therefore, injectable hydrogels are promising for the treatment of damaged tissue. This review will contribute to a better understanding of injectable hydrogels as potential scaffolds and drug delivery system for neural tissue engineering applications.

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Section: Hydrogel Scaffolds Used In the Regeneration Of The Nervous S...mentioning

confidence: 99%

Section: Hydrogel Scaffolds Used In the Regeneration Of The Nervous S...mentioning

confidence: 99%

Injectable Hydrogels for Nervous Tissue Repair—A Brief Review

Politrón-Zepeda,

Fletes-Vargas,

Rodríguez-Rodríguez

2024

Gels

Self Cite

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“…The resulting composite nanobers displayed a smooth, uniform structure with hydrophobic properties. [57][58][59][60][61][62][63][64][65][66][67][68] Additionally, the presence of starch and chitosan promoted L929 cell migration, aiding in wound healing. Overall, these nanobers have the potential to eliminate pathogens and enhance wound healing.…”

Section: Capability Of Chitosan In Tissue Buildingmentioning

confidence: 99%

Advancements in application of chitosan and cyclodextrins in biomedicine and pharmaceutics: recent progress and future trends

Bahavarnia,

Hasanzadeh,

Bahavarnia

et al. 2024

RSC Adv.

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“…Clever hydrogel design can incorporate responsiveness to temperature, pH, ions, magnetic or electric fields, and biological species, among other external stimuli. [ 32,33 ]…”

Section: Introductionmentioning

confidence: 99%

“…Clever hydrogel design can incorporate responsiveness to temperature, pH, ions, magnetic or electric fields, and biological species, among other external stimuli. [32,33] Combination products, drug products that contain multiple APIs, have been shown to be therapeutically beneficial for clinical applications including hypertension, [34,35] diabetes, tuberculosis, [36,37] and HIV. [38,39] Specifically, fixed dosage combinations (FDCs), which contain multiple APIs in the same physical tablet or capsule, are clinically valuable to reduce patient pill burden and improve patient compliance.…”

Section: Introductionmentioning

confidence: 99%

Orthogonal Gelations to Synthesize Core–Shell Hydrogels Loaded with Nanoemulsion‐Templated Drug Nanoparticles for Versatile Oral Drug Delivery

Attia

Chen

Doyle

2023

Adv Healthcare Materials

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Hydrophobic active pharmaceutical ingredients are ubiquitous in the drug development pipeline, but their poor bioavailability often prevents their translation into drug products. Industrial processes to formulate hydrophobic APIs are expensive, difficult to optimize, and not flexible enough to incorporate customizable drug release profiles into drug products. Here, a novel, dual‐responsive gelation process that exploits orthogonal thermo‐responsive and ion‐responsive gelations is introduced. This one‐step “dual gelation” synthesizes core‐shell (methylcellulose‐alginate) hydrogel particles and encapsulates drug‐laden nanoemulsions in the hydrogel matrices. In situ crystallization templates drug nanocrystals inside the polymeric core, while a kinetically stable amorphous solid dispersion is templated in the shell. Drug release is explored as a function of particle geometry, and programmable release is demonstrated for various therapeutic applications including delayed pulsatile release and sequential release of a model fixed‐dose combination drug product of ibuprofen and fenofibrate. Independent control over drug loading between the shell and the core is demonstrated. This formulation approach is shown to be a flexible process to develop drug products with biocompatible materials, facile synthesis, and precise drug release performance. This work suggests and applies a novel method to leverage orthogonal gel chemistries to generate functional core‐shell hydrogel particles.This article is protected by copyright. All rights reserved

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Stimuli-Responsive Hydrogels in Drug Delivery

Cited by 5 publications

References 163 publications

Injectable Hydrogels for Nervous Tissue Repair—A Brief Review

Injectable Hydrogels for Nervous Tissue Repair—A Brief Review

Advancements in application of chitosan and cyclodextrins in biomedicine and pharmaceutics: recent progress and future trends

Orthogonal Gelations to Synthesize Core–Shell Hydrogels Loaded with Nanoemulsion‐Templated Drug Nanoparticles for Versatile Oral Drug Delivery

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