Stimuli-responsive multilayer chitosan hollow microspheres via layer-by-layer assembly

Lu, Chunyin; Mu, Bin; Liu, Peng

doi:10.1016/j.colsurfb.2010.11.029

Cited by 39 publications

(19 citation statements)

References 20 publications

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“…erefore, the shis of the characteristic bands of CS in the spectrum of the composite microcapsules could be attributed to the presence of Fe 3 O 4 nanoparticles in the CS matrix. Moreover, the shis indicate strong interaction between CS and the Fe 3 O 4 nanoparticles [20,[27][28][29], so that, the interaction bene�ts the stabilization of the formed Fe 3 O 4 nanoparticles by the neighboring CS molecules and prevents them from agglomerating, which is consistent with the SEM and TEM observations. e interaction between 6 Journal of Chemistry CS and the Fe 3 O 4 nanoparticles may also interfere with the crystallization of CS, as shown in Figure 5.…”

Section: Microstructures Of the Microcapsulessupporting

confidence: 85%

“…Aer removal of the sulfonated polystyrene core, chitosan hollow microspheres were obtained to have an average diameter of about 842 ± 41 nm. Stimuli-responsive multilayer chitosan hollow microspheres were fabricated by sacri�cial template method combined with a sequential layer-by-layer electrostatic assembly technique [20]. erein, polystyrene sulfonate templates were used to absorb polycations of CS molecules, which then absorb polyanions of carboxymethyl chitosan.…”

Section: Introductionmentioning

confidence: 99%

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Preparation and Characterization of Magnetic Chitosan Microcapsules

Xiong

Wang

Zou

et al. 2012

Journal of Chemistry

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By dispersing aqueous precipitant in liquid paraffin to prepare a W/O emulsion then adding chitosan (CS) solution, CS microcapsules have been successfully prepared. It is a facile way to prepare polymer microcapsules by using aqueous precipitant or nonsolvent as template, which avoids the removal of template and would free from the necessity to cross-link the microcapsule as usual methods to directly form dense shell. The hollow feature of the obtained materials is revealed. The diameter of the microcapsules ranges from severalμm to over 100 μm. Magnetic CS microcapsules have been prepared in this way when Fe3+and Fe2+were mixed with CS to prepare a mixture starting solution. The appearance and microstructure of the composite microcapsules were studied. The results indicate that the formed Fe3O4nanoparticles are embedded in the CS matrix evenly due to strong interaction between the Fe3O4nanoparticles and the CS molecules. The Fe3O4content and the magnetic properties of the composite microcapsule were measured. The composite microcapsules were calcined in air at 700°C to prepare pure inorganic hollow microspheres. It is general to prepare hollow polymeric or composite particles by using this method.

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Section: Microstructures Of the Microcapsulessupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Magnetic Chitosan Microcapsules

Xiong

Wang

Zou

et al. 2012

Journal of Chemistry

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“…9 In addition to the applications mentioned above, polymeric hollow microspheres have also been found potential applications in several areas such as medical diagnosis, e-ink and photonics. 10,11 A variety of methods have been used for synthesis of the polymeric hollow microspheres, such as stepwise alkali-acid method, 12 template method, [13][14][15] self-assembly method, [16][17][18] precipitation polymerization and emulsion polymerization. [19][20][21][22][23] In order to obtain these unique properties, it is necessary to control their morphologies such as microsphere size, pore size and porosity.…”

mentioning

confidence: 99%

Facile route to synthesis and morphology control of anionic waterborne polyurethane hollow microspheres via self-crosslinking reaction

Guo

Wang

et al. 2015

RSC Adv.

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“…15−17 Some hollow microspheres (microcapsules) can even not only further increase drugloading efficiency, but also enhance stimuli-responsive ability. 18 Therefore, many methods, including emulsion cross-linking, 19 ionic gelation, 20 complex coacervation, 21 spray drying, 22 and self-assembly, 23,24 have been developed to design and prepare polymer-based hollow microspheres based on biocompatible polymers and biomacromolecules.…”

Section: Introductionmentioning

confidence: 99%

Adaptive Chitosan Hollow Microspheres as Efficient Drug Carrier

et al. 2017

Biomacromolecules

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Smart drug carrier with function-oriented adaptations is highly desired due to its unique properties in medical applications. Herein, adaptive chitosan hollow microspheres (CHM) are fabricated by employing interfacial Schiff-base bonding reaction. Hydrophilic macromolecules of glycol chitosan are fixed at the oil/water interface through numerous hydrophobic small molecules of borneol 4-formylbenzoate, forming the CHM with a positively charged surface and lipophilic cavity. These CHM have an average size of 400-1000 nm after passing through the 0.22 μm apertures of filter paper. This phenomenon combined with SEM measurements demonstrates its remarkable shape-adaptive behavior. Furthermore, the CHM present a pH-dependence of structural stability. When pH value reduces from 7.06 to 5.01, the CHM begin to lose their integrity. All those characteristics make the CHM an intelligent drug carrier, especially for water-insoluble anticancer drugs, paclitaxel (PTX) in particular. Both cell uptake and cell cytotoxicity assays suggest that the PTX-loaded CHM are highly efficient on HepG2 and A549 cells. Therefore, rather than most of the traditional materials, these adaptive CHM show great potential as a novel drug carrier.

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Stimuli-responsive multilayer chitosan hollow microspheres via layer-by-layer assembly

Cited by 39 publications

References 20 publications

Preparation and Characterization of Magnetic Chitosan Microcapsules

Preparation and Characterization of Magnetic Chitosan Microcapsules

Facile route to synthesis and morphology control of anionic waterborne polyurethane hollow microspheres via self-crosslinking reaction

Adaptive Chitosan Hollow Microspheres as Efficient Drug Carrier

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