Stimuli‐Responsive Nanoparticles Combining Photodynamic Therapy and Mitochondria Disruption Suppressed Tumor Metastasis

Li, Xiang; Zhou, Zhou; Yang, Jiatao; Zhou, Minglu; Li, Qiuyi; Li, Lian; Huang, Yuan

doi:10.1002/admi.202002200

Cited by 13 publications

(9 citation statements)

References 59 publications

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“…Finally, Dox-GA subsequently targeted mitochondria to reduce the O2 level to maximize the efficacy of PDT. Adapted with permission from (Li et al, 2021) Frontiers in Bioengineering and Biotechnology | www.frontiersin.org June 2022 | Volume 10 | Article 916952 Sameiyan et al, 2021). Gu's group developed an ATP-responsive nanogel (Dox/NG) consisting of a DNA motif containing an ATP aptamer and its complementary strand with doxorubicin insertion, protamine, and a hyaluronic acid (HA)-crosslinked shell (Mo et al, 2014).…”

Section: Atp-responsive Ddsmentioning

confidence: 99%

“…Inspired by the natural substrates for enzymes found in living organisms, researchers have also developed many nanomedicines with intrinsic enzyme responsiveness using these substrates. Indeed, Huang’s group established an MMP-2-responsive nanoparticle using gelatin as the basic framework ( Li et al, 2021 ). The nanoparticle (GD/Ce6@GNP) consists of a gelatin core encapsulating photosensitizer chlorin e6 (Ce6) and a polymeric shell chemically conjugated to mitochondria-targeted anticancer drugs (doxorubicin-glycyrrhetinic acid conjugates) on the surface.…”

Section: Internal Stimulus-responsive Ddsmentioning

confidence: 99%

“…Finally, Dox–GA subsequently targeted mitochondria to reduce the O2 level to maximize the efficacy of PDT. Adapted with permission from ( Li et al, 2021 )…”

Section: Internal Stimulus-responsive Ddsmentioning

confidence: 99%

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Recent Progress in Bio-Responsive Drug Delivery Systems for Tumor Therapy

Cong

2022

Front. Bioeng. Biotechnol.

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Spatially- and/or temporally-controlled drug release has always been the pursuit of drug delivery systems (DDSs) to achieve the ideal therapeutic effect. The abnormal pathophysiological characteristics of the tumor microenvironment, including acidosis, overexpression of special enzymes, hypoxia, and high levels of ROS, GSH, and ATP, offer the possibility for the design of stimulus-responsive DDSs for controlled drug release to realize more efficient drug delivery and anti-tumor activity. With the help of these stimulus signals, responsive DDSs can realize controlled drug release more precisely within the local tumor site and decrease the injected dose and systemic toxicity. This review first describes the major pathophysiological characteristics of the tumor microenvironment, and highlights the recent cutting-edge advances in DDSs responding to the tumor pathophysiological environment for cancer therapy. Finally, the challenges and future directions of bio-responsive DDSs are discussed.

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Section: Atp-responsive Ddsmentioning

confidence: 99%

Section: Internal Stimulus-responsive Ddsmentioning

confidence: 99%

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Recent Progress in Bio-Responsive Drug Delivery Systems for Tumor Therapy

Cong

2022

Front. Bioeng. Biotechnol.

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“…Being different from the traditional therapies, such as surgery, chemotherapy and radiotherapy, photodynamic therapy (PDT) uses a photosensitizer to transfer laser energy to oxygen molecules to generate reactive oxygen species (ROS) to kill cancer cells. 13–17 PDT offers apparent advantages of being noninvasive, exhibiting non drug resistance with few side effects and becomes an important treatment of cancer. 18–21 However, the low delivery efficiency of photosensitizers in vivo and the high dependence on oxygen limit its therapeutic effect on hypoxic solid tumors.…”

Section: Introductionmentioning

confidence: 99%

Combined Prussian Blue Nanozyme Carriers Improve Photodynamic Therapy and Effective Interruption of Tumor Metastasis

Shen¹,

Han²,

Yu³

et al. 2022

IJN

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Introduction Photodynamic therapy (PDT) as a new technique for theranostics is to kill tumor cells by activating photosensitizer and interacting with oxygen (O 2 ) to produce reactive oxygen species (ROS). However, the hypoxic tumor microenvironment (TME) may constrain the efficacy of PDT. Moreover, the lack of O 2 in TME also up-regulates the expression of HIF-1α and promotes tumor metastasis, which is also a leading cause of death for terminal cancer patients. Methods Prussian blue (PBs) was firstly synthesized by hydrothermal method, which was then etched by hydrochloric acid to obtained hollow Prussian blue nanoparticles (HPBs). Afterwards, Au-Pt nanozymes were in situ growing on the HPBs by reduction method to prepare Au-Pt@HPBs (APHPBs). Owing to the hollow structure of APHPBs, photosensitizer Ce6 can be easily and efficiently loaded into it to obtain Ce6-Au-Pt@HPBs (Ce6-APHPBs). After ce6-APHPBS regulation, photoacoustic imaging and hypoxic fluorescence imaging were then used to evaluate changes in hypoxic TME in vivo. Finally, under the assistant of Ce6-APHPBs, we evaluated the inhibitory effect of enhanced PDT on primary and metastatic tumors. Results We first designed and synthesized Ce6 loaded hollow prussian blue nanoparticles with Au-Pt nanozymes grown in situ on it. Both in vitro and in vivo experiments show that the prepared Ce6-APHPBs have good biosafety and could effectively degrade the overexpressed H 2 O 2 in TME to generate O 2 , further relieve the hypoxic TME and thus enhance the effect of PDT. At the same time, the increasing O 2 content could also reduce the expression of HIF-1α at the tumor site, which could reduce lung metastasis. Conclusion Ce6-APHPBs designed by us could not only efficiently enhance PDT but also regulate TME to reduce tumor metastasis and prolong survival of mice, which provide a novel idea and strategy for clinical PDT and metastatic tumor.

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“…Photosensitizers that can generate ROS upon light irradiation have been widely used in antitumor therapies and antibacterial surfaces. [36,37] In this research, we constructed a chlorin e6 (Ce6) incorporated PCL substrate by ultrasonic spray technique (Scheme 1). We verified that the 660 nm laser irradiation-induced the continuous generation of ROS from the surface, which promoted localized dopamine oxidation and in situ PDA coating formation.…”

Section: Introductionmentioning

confidence: 99%

Laser‐Triggered Interfacial Generation of ROS Promotes a Rapid Fabrication of Polydopamine Coating

Fang

Wang

Zou

et al. 2022

Macro Materials & Eng

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Mussel-inspired polydopamine (PDA) coating has been proved to be a universal surface modification strategy with remarkable versatility and active post-modification ability. However, the traditional preparation of PDA coating shows low polymerization efficiency and alkaline environment dependency. Herein, a robust method to accelerate the in situ generation of PDA coating based on a photosensitizer entrapped substrate is reported. It is demonstrated that the chlorin e6 (Ce6)-incorporated substrates induce sustained reactive oxygen species (ROS) production via laser irradiation at 660 nm, which dramatically promotes the preparation of PDA coating even in acidic conditions. The thickness of the PDA coating reaches over 4 nm with only 10 min irradiation (pH 6). Patterned PDA coatings can also be achieved by using a photomask. The functionality of this interfacial ROS-induced PDA coating including photothermal ability and secondary modification ability is also verified. The obtained PDA coating realizes the reduction of Ag + to Ag NPs, which shows excellent antibacterial ability. This interfacial ROS generation strategy offers a facile and efficient way to construct the PDA coating and expands the potential applications in the biomedical field.

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Stimuli‐Responsive Nanoparticles Combining Photodynamic Therapy and Mitochondria Disruption Suppressed Tumor Metastasis

Cited by 13 publications

References 59 publications

Recent Progress in Bio-Responsive Drug Delivery Systems for Tumor Therapy

Recent Progress in Bio-Responsive Drug Delivery Systems for Tumor Therapy

Combined Prussian Blue Nanozyme Carriers Improve Photodynamic Therapy and Effective Interruption of Tumor Metastasis

Laser‐Triggered Interfacial Generation of ROS Promotes a Rapid Fabrication of Polydopamine Coating

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