Stimuli-responsive nucleic acid nanostructures for efficient drug delivery

Yang, Changping; Wu, Xiaohui; Liu, Jianbing; Ding, Baoquan

doi:10.1039/d2nr05316k

Cited by 13 publications

(11 citation statements)

References 90 publications

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“…With the development of nucleic acid self‐assembly technology, nucleic acid‐based nanostructures have been employed for mRNA delivery due to their good biocompatibility, facile modification, and structural programmability. [ 84,137 ,. 138 ] For instance, Yoshinaga et al.…”

Section: Types Of Mrna Cargos and Delivery Systemsmentioning

confidence: 99%

Cellular Trafficking of Nanotechnology‐Mediated mRNA Delivery

Huang,

Deng,

Wang

et al. 2023

Advanced Materials

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Messenger RNA (mRNA)‐based therapy has emerged as a powerful, safe, and rapidly scalable therapeutic approach that involves technologies for both mRNA itself and the delivery vehicle. Although there are some unique challenges for different applications of mRNA therapy, a common challenge for all mRNA therapeutics is the transport of mRNA into the target cell cytoplasm for sufficient protein expression. This review is focused on the behaviors at the cellular level of nanotechnology‐mediated mRNA delivery systems, which have not been comprehensively reviewed yet. First, the four main therapeutic applications of mRNA are introduced, including immunotherapy, protein replacement therapy, genome editing, and cellular reprogramming. Second, common types of mRNA cargos and mRNA delivery systems are summarized. Third, strategies to enhance mRNA delivery efficiency during the cellular trafficking process are highlighted, including accumulation to the cell, internalization into the cell, endosomal escape, release of mRNA from the nanocarrier, and translation of mRNA into protein. Finally, the challenges and opportunities for the development of nanotechnology‐mediated mRNA delivery systems are presented. This review can provide new insights into the future fabrication of mRNA nanocarriers with desirable cellular trafficking performance.

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Section: Types Of Mrna Cargos and Delivery Systemsmentioning

confidence: 99%

Cellular Trafficking of Nanotechnology‐Mediated mRNA Delivery

Huang,

Deng,

Wang

et al. 2023

Advanced Materials

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“…Among all the stimuli, such as metal ions, pH, enzymes, and heat, light is alluring since it can activate a system with incredibly high temporal and spatial accuracy by an ON/ OFF switching mechanism. [38][39][40] Light is also traceless to avoid the possible accumulation of undesired waste materials in the dynamic assembly system. Meanwhile, accurate control of the wavelength and intensity of light is possible, and light activation is typically reversible.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, various stimuli‐responsive groups can be site‐specifically incorporated in the versatile DNA nanomaterials through efficient chemical modification and controlled self‐assembly. Among all the stimuli, such as metal ions, pH, enzymes, and heat, light is alluring since it can activate a system with incredibly high temporal and spatial accuracy by an ON/OFF switching mechanism [38–40] . Light is also traceless to avoid the possible accumulation of undesired waste materials in the dynamic assembly system.…”

Section: Introductionmentioning

confidence: 99%

Light Responsive DNA Nanomaterials and Their Biomedical Applications

Aqib,

Umer,

et al. 2024

Chemistry An Asian Journal

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DNA nanomaterials have been widely employed for various biomedical applications. With rapid development of chemical modification of nucleic acid, serials of stimuli‐responsive elements are included in the multifunctional DNA nanomaterials. In this review, we summarize the recent advances in light responsive DNA nanomaterials based on photocleavage/photodecage, photoisomerization, and photocrosslinking for efficient bioimaging (including imaging of small molecule, microRNA, and protein) and drug delivery (including delivery of small molecule, nucleic acid, and gene editing system). We also discuss the remaining challenges and future perspectives of the light responsive DNA nanomaterials in biomedical applications.

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“…Injectable hydrogels, such as chitosan-based hydrogels, have shown potential for precise and non-invasive drug delivery [ 29 ]. Nucleic acid nanostructures have been engineered to respond to various stimuli, including pH, redox gradient, and light, for drug delivery applications [ 30 ]. Responsive delivery systems based on pH, light, and redox-cleavable polymers have been developed for controlled drug release [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and biological evaluation of titanium dioxide/thiopolyurethane composite: anticancer and antibacterial effects

El Sadda,

Eissa,

Elafndi

et al. 2024

BMC Chemistry

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Nanocomposites incorporating titanium dioxide (TiO2) have a significant potential for various industrial and medical applications. These nanocomposites exhibit selectivity as antimicrobial and anticancer agents. Antimicrobial activity is crucial for medical uses, including applications in food processing, packaging, and surgical instruments. Additionally, these nanocomposites exhibit selectivity as anticancer agents. A stable nanocomposite as a new anticancer and antibacterial chemical was prepared by coupling titanium dioxide nanoparticles with a polyurethane foam matrix through the thiourea group. The titanium dioxide/thiopolyurethane nanocomposite (TPU/TiO2) was synthesized from low-cost Ilmenite ore and commercial polyurethane foam. EDX analysis was used to determine the elemental composition of the titanium dioxide (TiO2) matrix. TiO2NPs were synthesized and were characterized using TEM, XRD, IR, and UV–Vis spectra. TiO2NPs and TPU foam formed a novel composite. The MTT assay assessed Cisplatin and HepG-2 and MCF-7 cytotoxicity in vitro. Its IC50 values for HepG-2 and MCF-7 were 122.99 ± 4.07 and 201.86 ± 6.82 µg/mL, respectively. The TPU/TiO2 exhibits concentration-dependent cytotoxicity against MCF-7 and HepG-2 cells in vitro. The selective index was measured against both cell lines; it showed its safety against healthy cells. Agar well-diffusion exhibited good inhibition zones against Escherichia coli (12 mm), Bacillus cereus (10 mm), and Aspergillus niger (19 mm). TEM of TPU/TiO2-treated bacteria showed ultrastructure changes, including plasma membrane detachment from the cell wall, which caused lysis and bacterial death. TPU/TiO2 can treat cancer and inhibit microbes in dentures and other items. Also, TPU/TiO2 inhibits E. coli, B. cereus, and A. niger microbial strains.

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Stimuli-responsive nucleic acid nanostructures for efficient drug delivery

Abstract: Based on the complementary base pairing, nucleic acid molecules have acted as engineerable building blocks to fabricate versatile nanostructures with unique shapes and sizes. Benefiting from excellent programmability and biocompatibility,...

Cited by 13 publications

References 90 publications

Cellular Trafficking of Nanotechnology‐Mediated mRNA Delivery

Cellular Trafficking of Nanotechnology‐Mediated mRNA Delivery

Light Responsive DNA Nanomaterials and Their Biomedical Applications

Synthesis and biological evaluation of titanium dioxide/thiopolyurethane composite: anticancer and antibacterial effects

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