Stimuli-Responsive Polymeric Nanoplatforms for Cancer Therapy

Chen, Di; Ma, Yuanyuan; Xu, Xiaoxuan; Xie, Jianping; Ju, Shenghong

doi:10.3389/fbioe.2021.707319

Cited by 77 publications

(43 citation statements)

References 200 publications

(233 reference statements)

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“…Most of the data discussed here are in vitro studies, but some systematic reviews on the use of nanocarriers in clinical trials (Dri et al, 2021), reviews on nanomedicine and the clinical application of various nanoparticles (Chang et al, 2021;Mitchell et al, 2021) can be consulted for further reading.…”

Section: Introductionmentioning

confidence: 99%

Natural Compounds With Antimicrobial and Antiviral Effect and Nanocarriers Used for Their Transportation

Stan

Enciu

Mateescu³

et al. 2021

Front. Pharmacol.

120

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Due to the increasing prevalence of life-threatening bacterial, fungal and viral infections and the ability of these human pathogens to develop resistance to current treatment strategies, there is a great need to find and develop new compunds to combat them. These molecules must have low toxicity, specific activity and high bioavailability. The most suitable compounds for this task are usually derived from natural sources (animal, plant or even microbial). In this review article, the latest and most promising natural compounds used to combat bacteria, filamentous fungi and viruses are presented and evaluated. These include plant extracts, essential oils, small antimicrobial peptides of animal origin, bacteriocins and various groups of plant compounds (triterpenoids; alkaloids; phenols; flavonoids) with antimicrobial and antiviral activity. Data are presented on the inhibitory activity of each natural antimicrobial substance and on the putative mechanism of action against bacterial and fungal strains. The results show that among the bioactive compounds studied, triterpenoids have significant inhibitory activity against coronaviruses, but flavonoids have also been shown to inhibit SARS-COV-2. The last chapter is devoted to nanocarriers used to improve stability, bioavailability, cellular uptake/internalization, pharmacokinetic profile and reduce toxicity of natural compunds. There are a number of nanocarriers such as liposomes, drug delivery microemulsion systems, nanocapsules, solid lipid nanoparticles, polymeric micelles, dendrimers, etc. However, some of the recent studies have focused on the incorporation of natural substances with antimicrobial/antiviral activity into polymeric nanoparticles, niosomes and silver nanoparticles (which have been shown to have intrinsic antimicrobial activity). The natural antimicrobials isolated from animals and microorganisms have been shown to have good inhibitory effect on a range of pathogens, however the plants remain the most prolific source. Even if the majority of the studies for the biological activity evaluation are in silico or in vitro, their internalization in the optimum nanocarriers represents the future of “green therapeutics” as shown by some of the recent work in the field.

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Section: Introductionmentioning

confidence: 99%

Natural Compounds With Antimicrobial and Antiviral Effect and Nanocarriers Used for Their Transportation

Stan

Enciu

Mateescu³

et al. 2021

Front. Pharmacol.

120

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“…Finding efficient systems for the targeted delivery of drugs and contrast agents to tumor growth areas and the stimulus-sensitive release of both drugs and agents is essential; therefore, it is at the forefront of the development of theranostic agents for the combined diagnosis and treatment of tumors [1,2].…”

Section: Introductionmentioning

confidence: 99%

Designing Functionalized Polyelectrolyte Microcapsules for Cancer Treatment

et al. 2021

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The engineering of delivery systems for drugs and contrasting labels ensuring the simultaneous imaging and treatment of malignant tumors is an important hurdle in developing new tools for cancer therapy and diagnosis. Polyelectrolyte microcapsules (MCs), formed by nanosized interpolymer complexes, represent a promising platform for the designing of multipurpose agents, functionalized with various components, including high- and low-molecular-weight substances, metal nanoparticles, and organic fluorescent dyes. Here, we have developed size-homogenous MCs with different structures (core/shell and shell types) and microbeads containing doxorubicin (DOX) as a model anticancer drug, and fluorescent semiconductor nanocrystals (quantum dots, QDs) as fluorescent nanolabels. In this study, we suggest approaches to the encapsulation of DOX at different stages of the MC synthesis and describe the optimal conditions for the optical encoding of MCs with water-soluble QDs. The results of primary characterization of the designed microcarriers, including particle analysis, the efficacy of DOX and QDs encapsulation, and the drug release kinetics are reported. The polyelectrolyte MCs developed here ensure a modified (prolonged) release of DOX, under conditions close to normal and tumor tissues; they possess a bright fluorescence that paves the way to their exploitation for the delivery of antitumor drugs and fluorescence imaging.

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“…Taking advantage of the properties, versatility, and control of light, photoactive molecules-such as azobenzenes, photosensitizers and ortho-nitrobenzene; gold, upconversion nanoparticles (UCNPs), among others-have been used to produce photosensitive polymeric micro/nanocarriers and motors with the versatility of structures to respond to light stimuli [56][57][58][59]. They provide high external and non-invasive spatiotemporal control, accelerating the cargo release, activating photoreactions, fuel-free, and self-motion of micro/nanomotors via photo-isomerization, photo-cleavage, and thermophoresis mechanisms, which are of importance in the field of biophotonics [60][61][62][63].…”

Section: Introductionmentioning

confidence: 99%

Polymeric Micro/Nanocarriers and Motors for Cargo Transport and Phototriggered Delivery

Mena-Giraldo

Orozco

2021

Polymers

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Smart polymer-based micro/nanoassemblies have emerged as a promising alternative for transporting and delivering a myriad of cargo. Cargo encapsulation into (or linked to) polymeric micro/nanocarrier (PC) strategies may help to conserve cargo activity and functionality when interacting with its surroundings in its journey to the target. PCs for cargo phototriggering allow for excellent spatiotemporal control via irradiation as an external stimulus, thus regulating the delivery kinetics of cargo and potentially increasing its therapeutic effect. Micromotors based on PCs offer an accelerated cargo–medium interaction for biomedical, environmental, and many other applications. This review collects the recent achievements in PC development based on nanomicelles, nanospheres, and nanopolymersomes, among others, with enhanced properties to increase cargo protection and cargo release efficiency triggered by ultraviolet (UV) and near-infrared (NIR) irradiation, including light-stimulated polymeric micromotors for propulsion, cargo transport, biosensing, and photo-thermal therapy. We emphasize the challenges of positioning PCs as drug delivery systems, as well as the outstanding opportunities of light-stimulated polymeric micromotors for practical applications.

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Stimuli-Responsive Polymeric Nanoplatforms for Cancer Therapy

Cited by 77 publications

References 200 publications

Natural Compounds With Antimicrobial and Antiviral Effect and Nanocarriers Used for Their Transportation

Natural Compounds With Antimicrobial and Antiviral Effect and Nanocarriers Used for Their Transportation

Designing Functionalized Polyelectrolyte Microcapsules for Cancer Treatment

Polymeric Micro/Nanocarriers and Motors for Cargo Transport and Phototriggered Delivery

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