Stimuli-responsive single-chain polymeric nanoparticles towards the development of efficient drug delivery systems

Cheng, Chih‐Chia; Lee, Dong Hoon; Liao, Zhi-Sheng; Huang, Jyun-Jie

doi:10.1039/c6py01623e

Cited by 53 publications

(40 citation statements)

References 55 publications

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“…10 Several SCNPs are able to sense metal ions 11 and even proteins. 12 A variety of SCNP systems have been designed and constructed for bioimaging (e.g., magnetic resonance imaging, 13 single photon emission computerized tomography, 14 and fluorescence imaging 15 ) and drug delivery applications (e.g., controlled delivery of chiral amino acid derivatives, 16 peptides, 17 vitamins, 18 and drugs 19 ). Also, SCNPs have been employed for the development of all-polymer nanocomposites.…”

Section: Introductionmentioning

confidence: 99%

Melts of single-chain nanoparticles: A neutron scattering investigation

Arbe

Rubio

Molina

et al. 2020

Journal of Applied Physics

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The impact of purely intramolecular cross-linking on the properties of a polymer melt is studied by neutron diffraction and quasielastic incoherent and coherent neutron scattering on a system composed exclusively of single-chain nanoparticles. As a reference, a parallel study is presented on the melt of the linear precursor chains' counterpart. Associated with structural heterogeneities provoked by the internal compartmentalization due to cross-links, a dramatic slowing down of the relaxation of density fluctuations is observed at intermediate length scales.

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Section: Introductionmentioning

confidence: 99%

Melts of single-chain nanoparticles: A neutron scattering investigation

Arbe

Rubio

Molina

et al. 2020

Journal of Applied Physics

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“…Modern single‐chain nanoparticles (SCNPs) prepared by intramolecular cross‐linking of individual functional polymer chains can be considered as bioinspired soft nano‐objects with promising prospects for enzyme‐mimetic catalysis, nanomedicine and several other potential applications . Access to full perdeuterated functional polymer precursors to produce completely deuterated single‐chain nanoparticles (dSCNPs) for NS is limited by the fact that most of the functional monomers as well as reactive cross‐linkers currently in use are not commercially available in their deuterated version.…”

Section: Methodsmentioning

confidence: 99%

Facile Access to Completely Deuterated Single‐Chain Nanoparticles Enabled by Intramolecular Azide Photodecomposition

Rubio‐Cervilla

Molina

Robles‐Hernández

et al. 2019

Macromol. Rapid Commun.

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consequence of the momentum transfer dependence of the measured magnitudes, providing spatial resolution which can be tuned by choosing the proper probe and/or experimental conditions. In particular, neutron-scattering (NS) techniques provide two additional advantages for soft-matter investigations, such as: i) the possibility to match simultaneously the right length and time scales, and ii) the possibility to label selectively the components of a complex material via deuterium labeling. [2][3][4][5][6][7][8] Illustrative examples of the importance of deuterium labeling in polymeric systems were the pioneering experiments on labeled polymer melts realized in the 1970s [9,10] -as soon as the first small-angle neutron-scattering (SANS) instruments were developed-providing experimental evidence for the random coil conformation of linear macromolecules in bulk, as originally proposed by Flory. [11] Modern single-chain nanoparticles (SCNPs) prepared by intramolecular cross-linking of individual functional polymer chains can be considered as bioinspired soft nano-objects [12][13][14][15][16][17][18][19][20][21][22] with promising prospects for enzyme-mimetic catalysis, [23][24][25][26][27][28][29][30][31][32] nanomedicine [33][34][35][36][37][38][39][40][41] and several other potential applications. [42] Access to full perdeuterated functional polymer precursors to produce completely deuterated single-chain nanoparticles (dSCNPs) for NS is limited by the fact that most of the functional monomers as well as reactive cross-linkers currently in use are not commercially available in their deuterated version. Even with this severe limitation, NS studies with partially deuterated SCNPs have proven: i) the "crumple-globule"-like conformation of SCNPs when embedded in a linear polymeric matrix, [43,44] ii) the SCNP-induced matrix entanglement dilution in a polymer nanocomposite, [45] and iii) the confined dynamics of a low-T g polymer in the matrix of a nanocomposite rich in SCNPs, even at temperatures where the latter are above their T g . [46] However, deploying the full possibilities of the NS techniques for investigating the structure and dynamic features of SCNPs, as model macromolecules to address the effect of chain topology on materials properties, has been constrained by the absence of dSCNP samples. Their availability is a prerequisite for investigations of functions as important as, for example, the single-chain dynamic structure Single-Chain Nanoparticles Access to completely deuterated single-chain nanoparticles (dSCNPs) has remained an unresolved issue. Herein, the first facile and efficient procedure to produce dSCNPs is reported, which comprises: i) the use of commercially available perdeuterated cyclic ether monomers as starting reagents, ii) a ringopening copolymerization process performed in bulk to produce a neat dSCNP precursor, iii) a standard azidation reaction to decorate this precursor with azide moieties, and iv) a facile intramolecular azide photodecomposition step carried out under UV irradiation at...

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“…We hypothesized that by folding individual PVP chains at high dilution via intra-chain cross-linking [19], the resulting Povidone SCNPs will be endowed with local domains (pockets) to which drugs can be temporary immobilized for their subsequent controlled delivery. Previously, we and others have demonstrated the possibilities that SCNPs offer for the construction of responsive drug delivery nanocarriers [20][21][22]. A detailed analysis of recent findings in the field of drug delivery from SCNPs can be found in a relevant review paper by Kröger and Paulusse [23].…”

Section: Introductionmentioning

confidence: 97%

Preparation and Preliminary Evaluation of Povidone Single-Chain Nanoparticles as Potential Drug Delivery Nanocarriers

Asenjo-Sanz¹,

Del-Corte²,

Pinacho-Olaciregui³

et al. 2019

Med One

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One of the key areas in nanomedicine is the use of nanometer-sized materials as nanocarriers for therapeutic and diagnostic (theranostic) purposes. In particular, nanoparticles (NPs) have attracted a considerable attention due to their small size that confers the ability to be transported more easily through the body. Ideally, nanocarriers would be biocompatible and biodegradable so the involvement of soft matter-based NPs is an interesting approach. Folding individual polymer chains to single-chain nanoparticles (SCNPs) endows the resulting soft nano-objects with promising prospects for drug encapsulation and subsequent controlled delivery. In this work, we report on the preparation and preliminary (in vitro) evaluation of Povidone SCNPs as potential drug delivery nanocarriers. We select Povidone (polyvinylpyrrolidone) as a water-soluble polymer with a large commercial use in medicine, which is biocompatible and non-antigenic as well as safe for oral and topical applications. For evaluation of Povidone SCNPs as drug delivery nanocarriers, we select two drugs with reported anti-cancer activity: (i) Cisplatin, a widely used hydrophilic anticancer agent for treatment of a variety of cancer cells; and (ii) Lovastatin, a lipophilic compound with in vitro anti-proliferative, pro-apoptotic and anti-invasive effects in different cancer cell lines. After showing release of these drugs from Povidone SCNPs, we demonstrate that these nanoparticles can be rendered fluorescent in combination with functional aggregation-induced emission (AIE) fluorophore molecules paving the way to the potential development of theranostic Povidone SCNPs.

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Stimuli-responsive single-chain polymeric nanoparticles towards the development of efficient drug delivery systems

Abstract: Novel dynamic single-chain polymeric nanoparticles not only significantly improve drug transport efficiency in vitro but can also reside stably and facilitate precisely triggered drug-release in tumor-like microenvironments.

Cited by 53 publications

References 55 publications

Melts of single-chain nanoparticles: A neutron scattering investigation

Melts of single-chain nanoparticles: A neutron scattering investigation

Facile Access to Completely Deuterated Single‐Chain Nanoparticles Enabled by Intramolecular Azide Photodecomposition

Preparation and Preliminary Evaluation of Povidone Single-Chain Nanoparticles as Potential Drug Delivery Nanocarriers

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