Stimuli-responsive size-changeable strategy for cancer theranostics

Cheng, Guohui; Wu, Dan; Wang, Sheng; Zhang, Xu; Yu, Peng; Chang, Jin; Chen, Xiaoyuan

doi:10.1016/j.nantod.2021.101208

Cited by 36 publications

(23 citation statements)

References 193 publications

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“…It has been reported that nanoparticles with a size-enlargement effect are conducive to enhancing their tumor retention. 31,32 To further evaluate the tumor retention behaviour of CPMI NP, in vivo fluorescence imaging of the nanodrug was operated. After intravenous injection of CPMI NP to the 4T1 tumor-bearing mice, the tumor region was clearly imaged by NIR fluorescence (Fig.…”

Section: In Vivo Fluorescence Imagingmentioning

confidence: 99%

“…[25][26][27][28][29][30] Also, TMEactivated nanoparticles with size-enlargement ability show enhanced tumor retention, benefitting long-term tumor imaging and therapy. [31][32][33] Therefore, these activated functions can strongly enhance the accuracy and effectiveness of cancer theranostics. However, how to activate multiple functions with a single stimulus still remains a big challenge.…”

Section: Introductionmentioning

confidence: 99%

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Tumor microenvironment-activated multi-functional nanodrug with size-enlargement for enhanced cancer phototheranostics

et al. 2023

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Section: In Vivo Fluorescence Imagingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tumor microenvironment-activated multi-functional nanodrug with size-enlargement for enhanced cancer phototheranostics

et al. 2023

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“…Moreover, the IONPs with size larger than 10 nm exhibit a stronger T2 effect due to the high saturation magnetization. [71] To achieve signal enhancement, a series of stimuliÀresponsive NPs which can in vivo self-aggregate for enhanced tumor MRI have been exploited. [72][73][74] Gao and Yang's groups developed a GSH-responsive nanoprobe labeled with 99m Tc for in situ crosslinking of Fe 3 O 4 to aggregate into large-sized IONPs for enhanced dual-modality imaging (Figure 8a).…”

Section: Interparticle Crosslinking Reaction-driven Self-aggregationmentioning

confidence: 99%

Driving Forces Sorted In Situ Size‐Increasing Strategy for Enhanced Tumor Imaging and Therapy

et al. 2022

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Nanoparticles (NPs) with diverse functionalities are widely used in tumor diagnostic and therapeutic. However, the therapeutic efficiency is unsatisfactory because of the limited penetration depth as well as short retention time in a solid tumor, resulting in the inaccessibility of NPs and low tumor treatment efficiency. Therefore, it is of extreme vital significance to design NPs for simultaneously realizing deep penetration and long retention. Considering that the smaller‐sized NPs may penetrate deeply in tumor and large‐sized NPs show enhanced retention, many kinds of in situ size‐increasing strategies of NPs have recently been developed for precise tumor imaging and therapy. In this review, the recent progress of stimuli‐induced size increasing of NPs in vivo according to the driving forces inducing the aggregation of the smaller entity into bigger one with ordered or unordered structures in disease sites is summarized. The biomedical applications of the size‐increasing strategy in the field of tumor imaging and therapeutics are introduced. Finally, the potential challenges underlying this strategy are briefly listed and its possible future clinical transformation directions are envisioned.

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“…Larger particles (60–200 nm) are beneficial for extended retention time in vivo , while deep tumor penetration favors smaller particles (30–50 nm) . To overcome the dilemma of size, multistage nanoparticles with size-changeable property have been developed. − …”

Section: Introductionmentioning

confidence: 99%

Size Changeable Nanomedicines Assembled by Noncovalent Interactions of Responsive Small Molecules for Enhancing Tumor Therapy

Chen

Zeng

et al. 2022

ACS Appl. Mater. Interfaces

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The size of nanocarriers strongly affects their performance in biological systems, especially the capacity to overcome various barriers before delivering the payloads to destinations. However, the optimum size varies at different delivery stages in cancer therapy due to the complicated tumor microenvironment. Relatively large particles are favored for long-term circulation in vivo, while smaller particles contribute to deep penetration into tumor tissues. This dilemma in the size of particles stimulates the development of stimuli-responsive size-shrinking nanocarriers. Herein, we report a facile strategy to construct a tumor-triggered tannic acid (TA) nanoassembly with improved drug delivery efficiency. Cystamine (CA), a small molecule with a disulfide bond, is thus used to mediate TA assembling via cooperative noncovalent interactions, which endows the nanoassembly with intrinsic pH/GSH dual-responsiveness. The obtained TA nanoassemblies were systematically investigated. DOX encapsulated nanoassembly labeled TCFD NP shows high drug loading efficiency, pH/GSH-responsiveness and significant size shrinkage from 122 to 10 nm with simultaneous drug release. The in vitro and in vivo experimental results demonstrate the excellent biocompatibility, sufficient intracellular delivery, enhanced tumor retention/penetration, and superior anticancer efficacy of the small-molecule-mediated nanoassembly. This noncovalent strategy provides a simple method to fabricate a tumor-triggered size-changeable delivery platform to overcome biological barriers.

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Stimuli-responsive size-changeable strategy for cancer theranostics

Cited by 36 publications

References 193 publications

Tumor microenvironment-activated multi-functional nanodrug with size-enlargement for enhanced cancer phototheranostics

Tumor microenvironment-activated multi-functional nanodrug with size-enlargement for enhanced cancer phototheranostics

Driving Forces Sorted In Situ Size‐Increasing Strategy for Enhanced Tumor Imaging and Therapy

Size Changeable Nanomedicines Assembled by Noncovalent Interactions of Responsive Small Molecules for Enhancing Tumor Therapy

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