Stimuli-responsive supramolecular polymeric materials

Yan, Xuzhou; Wang, Rui; Zheng, Bo; Huang, Feihe

doi:10.1039/c2cs35091b

Cited by 1,504 publications

(1,030 citation statements)

References 305 publications

(362 reference statements)

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“…), thus enhancing the antitumoral efficiency 1, 2. Various stimuli‐responsive DDSs have been designed for cancer treatment, such as pH‐triggered nanocomposites,3, 4 GSH or temperature‐responsive nanoparticles,5, 6 and porous‐based smart nanoparticles 7, 8, 9. However, such DDS systems are still unsatisfactory and suffer from various shortcomings, including complicated synthetic processes and low repeatability due to complex designs, limited drug payloads, nonspecific drug leakage and nondegradable compositions 3, 5, 9.…”

Section: Introductionmentioning

confidence: 99%

“…Various stimuli‐responsive DDSs have been designed for cancer treatment, such as pH‐triggered nanocomposites,3, 4 GSH or temperature‐responsive nanoparticles,5, 6 and porous‐based smart nanoparticles 7, 8, 9. However, such DDS systems are still unsatisfactory and suffer from various shortcomings, including complicated synthetic processes and low repeatability due to complex designs, limited drug payloads, nonspecific drug leakage and nondegradable compositions 3, 5, 9. Thus, developing a novel stimuli‐responsive DDS with excellent biocompatibility, high drug payload, deep penetration into solid tumors, minimized nonspecific drug activation, and good repeatability with a simple strategy is urgently needed for cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

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Chemotherapeutic Drug Based Metal–Organic Particles for Microvesicle‐Mediated Deep Penetration and Programmable pH/NIR/Hypoxia Activated Cancer Photochemotherapy

Zhang

Cai

et al. 2018

Advanced Science

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A novel metal–organic particle (MOP) based nanodrug formed by mild self‐assembly of chemotherapeutic drugs, including banoxantrone and doxorubicin, through Cu(II)‐mediated coordination effects, is reported. In this nanodrug, Cu(II) acts as a bridge to join AQ4N and DOX, and then, self‐assembly of [‐AQ4N‐Cu(II)‐(DOX)2‐Cu(II)‐]n complexes forms nanosized MOPs (referred to as ADMOPs) through multiple interactions including host–metal–guest coordination, hydrophobic interactions, π‐stacking, and van der Waals force. The ADMOPs reported here have several important features over conventional drugs, including tumor microenvironment pH‐sensitive drug release that can be tracked by “turning on” the fluorescence of AQ4N or DOX through proton competition with Cu(II) to break the coordination bonds and much deeper penetration into solid tumors via microvesicle‐mediated intercellular transfer. Most strikingly, the ADMOPs can serve as stimuli‐responsive nanocarriers to efficiently load the photosensitizer phthalocyanine due to their inherent highly porous characteristics. Thus, the ADMOPs significantly enhance the chemotherapeutic efficacy by “on‐demand” photodynamic therapy, which further induces a hypoxic environment that enhances the reduction of AQ4N to systematically increase the therapeutic efficiency. Taken together, the designed ADMOPs composed of chemotherapeutic drugs may serve as a potential programmable controlled synergistic agent for cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chemotherapeutic Drug Based Metal–Organic Particles for Microvesicle‐Mediated Deep Penetration and Programmable pH/NIR/Hypoxia Activated Cancer Photochemotherapy

Zhang

Cai

et al. 2018

Advanced Science

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“…The reader is referred to a number of excellent general reviews of SMPs and their composites [82][83][84][85] for more exhaustive assessments of previously studied polymers and their properties. A Figure 6 The molecular mechanism of a dual shape memory polymer throughout a thermal cycle.…”

Section: Tendons-release Of Stored Energymentioning

confidence: 99%

Morphing in nature and beyond: a review of natural and synthetic shape-changing materials and mechanisms

2016

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Shape-changing materials open an entirely new solution space for a wide range of disciplines: from architecture that responds to the environment and medical devices that unpack inside the body, to passive sensors and novel robotic actuators. While synthetic shape-changing materials are still in their infancy, studies of biological morphing materials have revealed key paradigms and features which underlie efficient natural shape-change. Here, we review some of these insights and how they have been, or may be, translated to artificial solutions. We focus on soft matter due to its prevalence in nature, compatibility with users and potential for novel design. Initially, we review examples of natural shape-changing materials-skeletal muscle, tendons and plant tissues-and compare with synthetic examples with similar methods of operation. Stimuli to motion are outlined in general principle, with examples of their use and potential in manufactured systems. Anisotropy is identified as a crucial element in directing shape-change to fulfil designed tasks, and some manufacturing routes to its achievement are highlighted. We conclude with potential directions for future work, including the simultaneous development of materials and manufacturing techniques and the hierarchical combination of effects at multiple length scales.

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“…Owing to the dynamic nature of the noncovalent interactions, supramolecular polymers exhibit unique properties such as reversibility, stimuli‐responsiveness, self‐healing, and good processability 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30. Over the past decades, significant advances have been made in developing methods of supramolecular polymerization, from spontaneous to controllable and living supramolecular polymerization 31, 32, 33, 34, 35, 36, 37, 38.…”

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confidence: 99%

Supramolecular Interfacial Polymerization: A Controllable Method of Fabricating Supramolecular Polymeric Materials

et al. 2017

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A new method of supramolecular polymerization at the water–oil interface is developed. As a demonstration, an oil‐soluble supramonomer containing two thiol end groups linked by two ureidopyrimidinone units and a water‐soluble monomer bearing two maleimide end groups are employed. Supramolecular interfacial polymerization can be implemented by a thiol–maleimide click reaction at the water–chloroform interface to obtain supramolecular polymeric films. The glass transition temperature of such supramolecular polymers can be well‐tuned by simply changing the polymerization time and temperature. It is highly anticipated that this work will provide a facile and general approach to realize control over supramolecular polymerization by transferring the preparation of supramolecular polymers from solutions to water–oil interfaces and construct supramolecular materials with well‐defined properties.

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Stimuli-responsive supramolecular polymeric materials

Cited by 1,504 publications

References 305 publications

Chemotherapeutic Drug Based Metal–Organic Particles for Microvesicle‐Mediated Deep Penetration and Programmable pH/NIR/Hypoxia Activated Cancer Photochemotherapy

Chemotherapeutic Drug Based Metal–Organic Particles for Microvesicle‐Mediated Deep Penetration and Programmable pH/NIR/Hypoxia Activated Cancer Photochemotherapy

Morphing in nature and beyond: a review of natural and synthetic shape-changing materials and mechanisms

Supramolecular Interfacial Polymerization: A Controllable Method of Fabricating Supramolecular Polymeric Materials

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