Stimuli-Responsive Triblock Terpolymer Conversion into Multi-Stimuli-Responsive Micelles with Dynamic Covalent Bonds for Drug Delivery through a Quick and Controllable Post-Polymerization Reaction

Hlavatovičová, Eva; Fernandez‐Alvarez, Roberto; Byś, Katarzyna; Kereı̈che, Sami; Mandal, Tarun K.; Atanase, Leonard Ionuţ; Štěpánek, Miroslav; Uchman, Mariusz

doi:10.3390/pharmaceutics15010288

Cited by 11 publications

(8 citation statements)

References 54 publications

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“…They are connected by tight junctions, which prevent drug transport through the paracellular route. These tight junctions contribute to higher transendothelial electrical resistance (TEER) and prevent the passive diffusion of foreign components from the blood into the brain ( Singh et al, 2021 ; Eva et al, 2023 ). Pericytes and astrocytes provide support to BCECs and help maintain the function and structure of the BBB ( Fakhara Sabir et al, 2019 ).…”

Section: Barriers In Brain Targetingmentioning

confidence: 99%

“…Coating with lipophilic materials: In order to create a lipophilic shell around their hydrophilic core, nanogels can be coated or encapsulated with lipophilic substances like lipid bilayers or surfactants. Through passive diffusion or other transport processes that favour lipophilic molecules, the nanogels may be able to cross the BBB with the aid of this lipophilic coating ( Eva et al, 2023 ). 3.…”

Section: Barriers In Brain Targetingmentioning

confidence: 99%

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Nanogels as novel drug nanocarriers for CNS drug delivery

Manimaran

Nivetha

Tamilanban

et al. 2023

Front. Mol. Biosci.

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Nanogels are highly recognized as adaptable drug delivery systems that significantly contribute to improving various therapies and diagnostic examinations for different human diseases. These three-dimensional, hydrophilic cross-linked polymers have the ability to absorb large amounts of water or biological fluids. Due to the growing demand for enhancing current therapies, nanogels have emerged as the next-generation drug delivery system. They effectively address the limitations of conventional drug therapy, such as poor stability, large particle size, and low drug loading efficiency. Nanogels find extensive use in the controlled delivery of therapeutic agents, reducing adverse drug effects and enabling lower therapeutic doses while maintaining enhanced efficacy and patient compliance. They are considered an innovative drug delivery system that highlights the shortcomings of traditional methods. This article covers several topics, including the involvement of nanogels in the nanomedicine sector, their advantages and limitations, ideal properties like biocompatibility, biodegradability, drug loading capacity, particle size, permeability, non-immunological response, and colloidal stability. Additionally, it provides information on nanogel classification, synthesis, drug release mechanisms, and various biological applications. The article also discusses barriers associated with brain targeting and the progress of nanogels as nanocarriers for delivering therapeutic agents to the central nervous system.

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Section: Barriers In Brain Targetingmentioning

confidence: 99%

Section: Barriers In Brain Targetingmentioning

confidence: 99%

Nanogels as novel drug nanocarriers for CNS drug delivery

Manimaran

Nivetha

Tamilanban

et al. 2023

Front. Mol. Biosci.

View full text Add to dashboard Cite

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“…The organic solvent used must be miscible with water. The drug and polymer are dissolved in the organic solvent and placed in the dialysis bag, and dialysis takes place against the water [ 31 ]. This method has two major drawbacks [ 32 ].…”

Section: Polymeric Micellesmentioning

confidence: 99%

Polymeric-Micelle-Based Delivery Systems for Nucleic Acids

et al. 2023

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Nucleic acids can modulate gene expression specifically. They are increasingly being utilized and show huge potential for the prevention or treatment of various diseases. However, the clinical translation of nucleic acids faces many challenges due to their rapid clearance after administration, low stability in physiological fluids and limited cellular uptake, which is associated with an inability to reach the intracellular target site and poor efficacy. For many years, tremendous efforts have been made to design appropriate delivery systems that enable the safe and effective delivery of nucleic acids at the target site to achieve high therapeutic outcomes. Among the different delivery platforms investigated, polymeric micelles have emerged as suitable delivery vehicles due to the versatility of their structures and the possibility to tailor their composition for overcoming extracellular and intracellular barriers, thus enhancing therapeutic efficacy. Many strategies, such as the addition of stimuli-sensitive groups or specific ligands, can be used to facilitate the delivery of various nucleic acids and improve targeting and accumulation at the site of action while protecting nucleic acids from degradation and promoting their cellular uptake. Furthermore, polymeric micelles can be used to deliver both chemotherapeutic drugs and nucleic acid therapeutics simultaneously to achieve synergistic combination treatment. This review focuses on the design approaches and current developments in polymeric micelles for the delivery of nucleic acids. The different preparation methods and characteristic features of polymeric micelles are covered. The current state of the art of polymeric micelles as carriers for nucleic acids is discussed while highlighting the delivery challenges of nucleic acids and how to overcome them and how to improve the safety and efficacy of nucleic acids after local or systemic administration.

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“…Nanoscale copolymeric aggregates have been found to be particularly suitable as drug carriers. [27][28][29][30][31][32] Here, the hydrophilic corona acts as a stabilizing interface between the hydrophobic core and the outer environment, allowing them to solubilize poorly-soluble drugs and inhibit infected species in biological media, whereas the hydrophobic core acts as a microhabitat for lipophilic drugs. There are a number of drug delivery systems that have been created or are still being researched in order to reduce drug degradation and boost drug availability.…”

Section: Introductionmentioning

confidence: 99%