Stimuli-Sensitive Particles for Drug Delivery

Grainger, Stephanie; El-Sayed, Mohamed

doi:10.1142/9789814295680_0008

Cited by 32 publications

(36 citation statements)

References 79 publications

(103 reference statements)

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“…Hydrogels also have potential to enable integrated feedback-controlled drug delivery systems, which would self-regulate depending on therapeutic needs. Furthermore, they can be used to selectively deliver therapeutic agents to diseased tissues by utilizing certain cues that are specific to the targeted site [250]. Site-specific delivery minimizes many undesired effects that result from inefficient transport across biological barriers, non-preferred distribution of drugs in tissues, and off-target or systemic toxicity.…”

Section: Overview Of Gel-based Materials By Applicationmentioning

confidence: 99%

Role of mechanical factors in applications of stimuli-responsive polymer gels – Status and prospects

Goponenko

Dzenis

2016

Polymer

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Due to their unique characteristics such as multifold change of volume in response to minute change in the environment, resemblance of soft biological tissues, ability to operate in wet environments, and chemical tailorability, stimuli responsive gels represent a versatile and very promising class of materials for sensors, muscle-type actuators, biomedical applications, and autonomous intelligent structures. Success of these materials in practical applications largely depends on their ability to fulfill application-specific mechanical requirements. This article provides an overview of recent application-driven development of covalent polymer gels with special emphasis on the relevant mechanical factors and properties. A short account of mechanisms of gel swelling and mechanical characteristics of importance to stimuli-responsive gels is presented. The review highlights major barriers for wider application of these materials and discusses latest advances and potential future directions toward overcoming these barriers, including interpenetrating networks, homogeneous networks, nanocomposites, and nanofilamentary gels.

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Section: Overview Of Gel-based Materials By Applicationmentioning

confidence: 99%

Role of mechanical factors in applications of stimuli-responsive polymer gels – Status and prospects

Goponenko

Dzenis

2016

Polymer

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“…The monomers of PAA and DMAEMA have pKa of 6.7 and 8.3, respectively (21, 22). They undergo conformational changes at endosomal pH (acidic pH) and have been used to deliver agents into cytosolic compartments (2, 18).…”

Section: Resultsmentioning

confidence: 99%

Controlled Endolysosomal Release of Agents by pH-responsive Polymer Blend Particles

et al. 2015

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Purpose A key step of delivering extracellular agents to its intracellular target is to escape from endosomal/lysosomal compartments, while minimizing the release of digestive enzymes that may compromise cellular functions. In this study, we examined the intracellular distribution of both fluorecent cargoes and enzymes by a particle delivery platform made from the controlled blending of poly (lactic-co-glycolic acid) (PLGA) and a random pH-sensitive copolymer. Methods We utilized both microscopic and biochemical methods to semi-quantitatively assess how the composition of blend particles affects the level of endosomal escape of cargos of various sizes and enzymes into the cytosolic space. Results We demonstrated that these polymeric particles enabled the controlled delivery of cargos into the cytosolic space that was more dependent on the cargo size and less on the composition of blend particles. Blend particles did not induce the rupture of endosomal/lysosomal compartments and released less than 20% of endosomal/lysosomal enzymes. Conclusions This study provides insight into understanding the efficacy and safety of a delivery system for intracellular delivery of biologics and drugs. Blend particles offer a potential platform to target intracellular compartments while potentially minimizing cellular toxicity.

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“…Further, the microporous structure of the nanofiber system restricts the free access of the dissolution medium into the fiber matrix, and thereby causes extended drug release. The graph shows that 61.3% of the drug was released in 30 h. PLLA being an anionic polymer remained unionized at acidic pH for longer periods of time, thus facilitating the slow release of the drug from the nanofiber system (Grainger and El-Sayed 2010). The release profile, according to the Higuchi equation (R 2  0.966), showed characteristics of diffusion kinetics.…”

Section: Actual Drug Contentmentioning

confidence: 99%

Diacerein-Loaded novel gastroretentive nanofiber system using PLLA: Development andin vitrocharacterization

Malik

Garg

Goyal

et al. 2015

Artificial Cells, Nanomedicine, and Biotechnology

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The purpose of this research is to describe the utility of nanofibers as a gastroretentive dosage form and improve the solubility of diacerein (DIA) by using the above approach. Poly L-(lactic acid) (PLLA) nanofibers loaded with DIA were prepared using the electrospinning technique. The nanofibers developed were characterized for morphology, tensile strength, floating behavior, drug entrapment, drug solubility, mucoadhesive detachment force, and drug release profile. The results demonstrated that the drug-loaded nanofibers were smooth, discrete, & non-woven. Analysis by X-ray crystallography (XRD) revealed that the drug in the nanofiber was present in the amorphous state, which largely contributes to higher drug solubility in the nanofibers developed. The buoyancy study demonstrated that the nanofibers developed exhibited zero lag time. Approximately 61.3% of drug was released in 30 h, thus facilitating the slow release of the drug from the nanofiber system. Finally, we concluded that the electrospun nanofibers developed offer a promising gastroretentive drug delivery system to deliver DIA with improved solubility.

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Stimuli-Sensitive Particles for Drug Delivery

Cited by 32 publications

References 79 publications

Role of mechanical factors in applications of stimuli-responsive polymer gels – Status and prospects

Role of mechanical factors in applications of stimuli-responsive polymer gels – Status and prospects

Controlled Endolysosomal Release of Agents by pH-responsive Polymer Blend Particles

Diacerein-Loaded novel gastroretentive nanofiber system using PLLA: Development andin vitrocharacterization

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