Stimuli-sensitivity and dynamics in the self-assembly structure of TEMPO-containing nonamphiphilic nanoparticles and their triggering hydrophobic drug release

Uddin, Md Alim; Yu, Haojie; Yan, Sheng; Mehmood, Sahid; Amin, Bilal Ul; Liang, Ruihong

doi:10.1016/j.mtcomm.2021.103107

Materials Today Communications

2022

DOI: 10.1016/j.mtcomm.2021.103107

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Stimuli-sensitivity and dynamics in the self-assembly structure of TEMPO-containing nonamphiphilic nanoparticles and their triggering hydrophobic drug release

Md Alim Uddin

Haojie Yu

Sheng Yan

et al.

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Cited by 8 publications

References 69 publications

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One‐Pot Synthesis of Size‐Controlled Poly(cyclotriphosphazene‐co‐hesperetin) Microspheres and Their Properties as Drug Delivery Carriers

Mehmood

Uddin

et al. 2022

ChemistrySelect

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In this study, cross‐linked poly(cyclotriphosphazene‐co‐hesperetin) (PCTPHP) microspheres were synthesized by the reaction of hexachlorocyclotriphosphazene (HCCP) with hesperetin (HSP). Fourier transform infrared (FT‐IR) spectroscopy was used to confirm the successful preparation of the PCTPHP microspheres. The cross‐linking density of the prepared PCTPHP microspheres was examined by electron paramagnetic resonance (EPR) spectroscopy. The results showed that the increased HSP mole might be more suitable to cross‐link with HCCP in high density. The thermal properties, particle size distribution, morphology and crystalline nature of PCTPHP microspheres were investigated by thermogravimetric analysis (TGA), dynamic light scattering (DLS), scanning electron microscope (SEM) and X‐ray diffraction (XRD). The prepared PCTPHP‐3 microspheres were used as drug carriers. The 5‐fluorouracil (5‐FU) was loaded on the microspheres and their in vitro release behavior was observed at two different pH values. The results showed a controlled release of 5‐FU from the PCTPHP‐3/5‐FU in both basic and acidic mediums up to 216 h. The results showed that the PCTPHP microspheres might play a vital role as drug carriers in cancer therapy.

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One‐Pot Synthesis of Size‐Controlled Poly(cyclotriphosphazene‐co‐hesperetin) Microspheres and Their Properties as Drug Delivery Carriers

Mehmood

Uddin

et al. 2022

ChemistrySelect

Self Cite

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Study on synthesis of cross-linked poly(cyclotriphosphazene-co-luteolin) nanospheres and their properties for controlled drug delivery

Mehmood

Uddin

et al. 2022

Colloid Polym Sci

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Intertumoral and intratumoral barriers as approaches for drug delivery and theranostics to solid tumors using stimuli-responsive materials

Chenab,

Malektaj,

Nadinlooie

et al. 2024

Microchim Acta

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Stimuli-sensitivity and dynamics in the self-assembly structure of TEMPO-containing nonamphiphilic nanoparticles and their triggering hydrophobic drug release

Cited by 8 publications

References 69 publications

One‐Pot Synthesis of Size‐Controlled Poly(cyclotriphosphazene‐co‐hesperetin) Microspheres and Their Properties as Drug Delivery Carriers

One‐Pot Synthesis of Size‐Controlled Poly(cyclotriphosphazene‐co‐hesperetin) Microspheres and Their Properties as Drug Delivery Carriers

Study on synthesis of cross-linked poly(cyclotriphosphazene-co-luteolin) nanospheres and their properties for controlled drug delivery

Intertumoral and intratumoral barriers as approaches for drug delivery and theranostics to solid tumors using stimuli-responsive materials

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