Stimulierung der Calciumausscheidung im Pankreassaft von Hunden durch Pankreozymin

Goebell, H.; Steffen, Ch.; Bode, Ch.; Hupe, K

doi:10.1007/bf01497134

Cited by 11 publications

(2 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been demonstrated previously that intravenous injection of CCK-PZ produced a rapid increase in calcium and protein concentration in canine pancreatic juice secreted in response to secretin (Goebell, Steffen, Bode, and Hupe, 1970). The present data demonstrate that octa CCK-PZ, caerulein, and tetragastrin all caused a marked increase in amylase, protein, calcium, and zinc concentrations.…”

Section: Discussionsupporting

confidence: 76%

The action of the C-terminal octapeptide of cholecystokinin and related peptides on pancreatic exocrine secretion

Nakajima¹

1973

Gut

View full text Add to dashboard Cite

SUMMARY The effect of the C-terminal octapeptide of cholecystokinin-pancreozymin (CCK-PZ), caerulein, and the C-terminal tetrapeptide of gastrin on pancreatic secretion of fluid, electrolyte, amylase, and protein was studied in anaesthetized dogs prepared with pancreatic fistulae. Against background stimulation of fluid secretion with submaximal doses of secretin, all the polypeptides produced a qualitatively similar pancreatic response, causing a highly significant increase in amylase, protein, calcium, and zinc concentrations. Magnesium concentration was significantly increased only when the concentration preceding the administration of the peptide was below 100 ,u-equiv/l. Octa-CCK-PZ was 13-35 times and 20-56 times more potent than tetragastrin on weight and molar bases, respectively, as a stimulant of amylase secretion. The threshold doses were largest for amylase, lower for calcium, and lowest for zinc. A significant linear correlation was observed between amylase and calcium concentration, zinc and protein concentration, and magnesium and calcium concentration. The peptides produced some increase in secretin-induced volume flow, whereas bicarbonate, chloride, sodium, and potassium concentrations remained unchanged. The direct relation between bicarbonate concentration and flow rate was limited to rates below 1.5 ml/5 minutes. At higher rates bicarbonate and chloride concentration reached a high and low plateau, respectively, although the first five-min sample of pancreatic juice after secretin stimulation exhibited a relatively low bicarbonate and high chloride concentration compared with its voluminous flow. Chloride concentration varied inversely with bicarbonate concentration, the sum of the two anions being constant.The intestinal hormone cholecystokinin/pancreozymin (CCK-PZ), for which a partial structure has been proposed, is a single-chain polypeptide with 33 amino acid residues (Mutt and Jorpes, 1968). The C-terminal pentapeptide of CCK-PZ is structurally identical with that of the gastric hormone gastrin, and also of the decapeptide caerulein, isolated from the skin of Hyla caerulea (Anastasi, Erspamer, and Endean, 1968). Recently Plusec, Sheehan, Sabo, Williams, Kocy, and Ondetti (1970) have synthesized the C-terminal octapeptide of CCK-PZ (octa CCK-PZ) which possesses the biological activities of the full hormonal molecule.It has been demonstrated that octa CCK-PZ is more potent, on weight and molar bases, than the 'Address for correspondence: Sumio Nakajima, MD, 2nd

show abstract

Section: Discussionsupporting

confidence: 76%

The action of the C-terminal octapeptide of cholecystokinin and related peptides on pancreatic exocrine secretion

Nakajima¹

1973

Gut

View full text Add to dashboard Cite

show abstract

“…The survival of nonvascularized joint graft transfer has its limitations and was first described by Goebell. 1 Vascularized joint transfer has been described in literature as pedicled flap or as free tissue transfer from the toes or fingers. The metatarsophalangeal joint and proximal interphalangeal (PIP) joint of the foot are usually used for the finger joints reconstruction.…”

Section: Introductionmentioning

confidence: 99%

Free Vascularized Joint Transfer from Toes for Finger Reconstruction in a 2-Year-Old Child with Good Functional Recovery

Balan¹

2023

Journal of Hand and Microsurgery

View full text Add to dashboard Cite

A 2-year-old male child sustained injury to middle and ring fingers of the right hand following a road traffic accident. He had mutilated fingers with loss of middle phalanx along with proximal interphalangeal (PIP) joint, distal interphalangeal joint of middle finger, and loss of part of middle phalanx and PIP joint of the ring finger. There was dorsal tissue loss of both the fingers. With staged reconstructive strategy, we could salvage the fingers. In the initial part, the soft tissue reconstruction was done using pedicled groin flap. In the later stage, free PIP joint transfer from the second toes of both feet was used to reconstruct the bone and PIP joint of the ring and middle finger. A year following the joint transfer, the child had good functional outcome.

show abstract

Allgemeine Pathologie der Bauchspeicheldrüse

Becker¹

1976

Pankreas

View full text Add to dashboard Cite

Stimulierung der Calciumausscheidung im Pankreassaft von Hunden durch Pankreozymin

Cited by 11 publications

References 2 publications

The action of the C-terminal octapeptide of cholecystokinin and related peptides on pancreatic exocrine secretion

The action of the C-terminal octapeptide of cholecystokinin and related peptides on pancreatic exocrine secretion

Free Vascularized Joint Transfer from Toes for Finger Reconstruction in a 2-Year-Old Child with Good Functional Recovery

Allgemeine Pathologie der Bauchspeicheldrüse

Contact Info

Product

Resources

About