Stimulus-responsive liquids for encapsulation storage and controlled release of drugs from nano-shell capsules

Chang, Ming Wei; Stride, Eleanor; Edirisinghe, Mohan

doi:10.1098/rsif.2010.0428

Cited by 16 publications

(16 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this regard, electrohydrodynamic (EHD) processing is a promising technique for producing particles (electrospraying) and fibers (electrospinning) from a wide range of materials such as biocompatible polymers and hydrogels, proteins and peptides [20][21][22][23][24]. EHD processing can produce uniform solid and encapsulated particles and fibers with diameters ranging from a few nanometers to several micrometers in a single step, under ambient conditions, low cost and without the need for high concentrations of additives or surfactants.…”

Section: Introductionmentioning

confidence: 99%

Design, construction and performance of a portable handheld electrohydrodynamic multi-needle spray gun for biomedical applications

Sofokleous

Stride

Bonfield³

et al. 2013

Materials Science and Engineering: C

Self Cite

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Design, construction and performance of a portable handheld electrohydrodynamic multi-needle spray gun for biomedical applications

Sofokleous

Stride

Bonfield³

et al. 2013

Materials Science and Engineering: C

Self Cite

View full text Add to dashboard Cite

“…However, the major disadvantages of A microspheres is their low loading efficiency and also rapid release of proteins owing to the meshlike networks of the gel [18]. Previous studies have shown that a core-shell structure in drug -protein carriers can overcome the issues of limited loading efficiencies and rapid release of drug or protein [19][20][21]. We therefore hypothesized that introducing a core-shell structure into the A microspheres could solve the shortcomings of the pure A.…”

Section: Introductionmentioning

confidence: 99%

In situ preparation and protein delivery of silicate–alginate composite microspheres with core-shell structure

Fan

Gelinsky

et al. 2011

J. R. Soc. Interface.

View full text Add to dashboard Cite

The efficient loading and sustained release of proteins from bioactive microspheres remain a significant challenge. In this study, we have developed bioactive microspheres which can be loaded with protein and then have a controlled rate of protein release into a surrounding medium. This was achieved by preparing a bioactive microsphere system with core-shell structure, combining a calcium silicate (CS) shell with an alginate (A) core by a one-step in situ method. The result was to improve the microspheres' protein adsorption and release, which yielded a highly bioactive material with potential uses in bone repair applications. The composition and the core-shell structure, as well as the formation mechanism of the obtained CS -A microspheres, were investigated by X-ray diffraction, optical microscopy, scanning electron microscopy, energy dispersive spectrometer dot and line-scanning analysis. The protein loading efficiency reached 75 per cent in CS -A microspheres with a core-shell structure by the in situ method. This is significantly higher than that of pure A or CS -A microspheres prepared by non-in situ method, which lack a core-shell structure. CS -A microspheres with a core-shell structure showed a significant decrease in the burst release of proteins, maintaining sustained release profile in phosphate-buffered saline (PBS) at both pH 7.4 and 4.3, compared with the controls. The protein release from CS -A microspheres is predominantly controlled by a Fickian diffusion mechanism. The CS -A microspheres with a core-shell structure were shown to have improved apatite-mineralization in simulated body fluids compared with the controls, most probably owing to the existence of bioactive CS shell on the surface of the microspheres. Our results indicate that the core-shell structure of CS -A microspheres play an important role in enhancing protein delivery and mineralization, which makes these composite materials promising candidates for application in bone tissue regeneration.

show abstract

“…Although many research articles have been published in recent years 7,21,26,34,35 , CEHD processing is a relatively new method and thus, they are still many parameters that need to be investigated. In this work the goal was to use a two needle co-axial system with adjustable needle axial position to study how the displacement between the two needle tips affects the main characteristics and morphology of the core-shell particles and fibres produced.…”

Section: Introductionmentioning

confidence: 99%

The effect of needle tip displacement in co-axial electrohydrodynamic processing

et al. 2016

Self Cite

View full text Add to dashboard Cite

Co-axial electrospraying and electrospinning are versatile electrohydrodynamic (EHD) techniques that can be used to encapsulate a variety of materials in the form of polymeric particles and fibres via a one step process. The successful production of uniform encapsulated products in co-axial EHD (CEHD) processing depends on multiple parameters including solution concentration, applied voltage and needle capillary diameter. Although many studies have been conducted to investigate the effects of these parameters, there has been very limited research on how the axial displacement between the two needle tips affects the final products formed. Hence the purpose of this study was to adjust the positioning of the inner needle such that its tip extends beyond, is level with or resides inside that of the outer needle and to thus determine the most effective arrangement for controlling product size, uniformity and/or yield. Core-shell particles were prepared using two polymers, poly(lactic-co-glycolic) acid (PLGA) as the shell and polymethysilsesquioxane (PMSQ) as the core and core-shell fibres using PMSQ as the shell and a volatile liquid, perfluorohexane (PFH) as the core. The products formed were analyzed by optical microscopy, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). After analysis, it was concluded that the most effective arrangement for generating both particles and fibres with the optimal combination of size, uniformity and yield was to have the inner needle 2 mm inside the outer needle. This allows for formation of a stable cone-jet and successful encapsulation of the inner liquid within the outer liquid, before the outer stable conejet forms. The corresponding collected product diameter and percentage of products in which material was successfully encapsulated were found to be 0.6±0.1μm and 85±3% respectively for particles and 9±1μm and 92±2% for fibres.

show abstract

Stimulus-responsive liquids for encapsulation storage and controlled release of drugs from nano-shell capsules

Cited by 16 publications

References 36 publications

Design, construction and performance of a portable handheld electrohydrodynamic multi-needle spray gun for biomedical applications

Design, construction and performance of a portable handheld electrohydrodynamic multi-needle spray gun for biomedical applications

In situ preparation and protein delivery of silicate–alginate composite microspheres with core-shell structure

The effect of needle tip displacement in co-axial electrohydrodynamic processing

Contact Info

Product

Resources

About