Stimulus responsive peptide based materials

Abstract

In this tutorial review we give an introduction into the field of stimulus responsive peptide based materials illustrated by some recent and current developments. We have tried to categorize them according to the stimulus the materials are responsive to, being pH, temperature, metal ions, enzymes and light. Because we have focused on the structural changes that these stimuli effect we have further classified the topics according to the secondary structures that are involved. These changes in molecular structure in turn cause a change in the macroscopic properties of the material they constitute. It is believed that these materials, often referred to as smart materials, have a great potential being applicable in areas like drug delivery, tissue engineering and bio-sensors.

A Systematic Study on the Self-Assembly Behaviour of Multi Component Fmoc-Amino Acid-Poly(oxazoline) Systems

“…The ratio used is the following: propargyl/azide/CuSO 4 1:2:0.3. 2 equiv of azide and 0.3 equiv of CuSO 4 and ascorbic acid were dissolved in an aqueous solution containing the polymer (final volume 7 mL). The reaction was left overnight under stirring, before going through the purification process, using a membrane having a molecular weight cut off of 3.5 kDa.…”

“…This objective is often pursued through the use of polymers, whose properties and characteristics can be precisely tailored; often relying on a change in environmental conditions, e.g., change in ionic strength or pH value, to undergo morphological changes [4]. The use of enzyme responsive materials, has OPEN ACCESS attracted significant interest due to their capacity to operate under constant environmental conditions, i.e., a change in conditions is not required to activate their catalytic activity.…”

The unexpected advantages of using D-amino acids for peptide self-assembly into nanostructured hydrogels for medicine

“…The rise of selfassembling peptide nanostructures [2] and hydrogels has brought innovation to various medicinal fields [3], spanning from adaptive [4], biodegradable tissue engineering scaffolds [5] for wound healing and cell encapsulation, to unprecedented paradigms in drug delivery, and even targeted cell therapy [6]. Among the many peptide-based systems, lowmolecular-weight gelators deserve special mention as they possess an economic advantage over longer peptides or more complex peptide-based derivatives [7].…”

Terpolymerization kinetics of amino acid N‐carboxy anhydrides

“…Both the chemical variety of amino acids and the synergistic functionality that arises from specific amino acid sequences make polypeptides versatile molecules that perform a multitude of functions such as enzymatic catalysis, recognition events, and regulating processes. 1 The potential of peptides in materials science has been recognized [1][2][3] and over the last decades increasing efforts have been placed into designing functional peptide-based materials such as drug delivery vehicles, 4-10 peptide surfaces, [11][12][13][14] and selfassembling peptide-based gels. [15][16][17][18][19][20][21] As a result, preparation methods of peptides become more advanced.…”