STin2 Variant and Family History of Suicide as Significant Predictors of Suicide Completion in Major Depression

Lara, Catalina Lopez de; Dumais, Alexandre; Rouleau, Guy A.; Lesage, Alain; Dumont, M; Chawky, Nadia; Alda, Martin; Benkelfat, Chawki; Turecki, Gustavo

doi:10.1016/j.biopsych.2005.06.021

Cited by 54 publications

(33 citation statements)

References 64 publications

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“…No association was observed to bipolar disorder or suicidality in a Canadian family study 104 and in Canadian suicide attempters. 105 Similar negative findings were derived for Chinese mood disorder patients with suicidal history 106 or psychotic patients with suicidal behaviour. 95 Using DNA of Croatian suicide victims there was also no association between suicide and the VNTR-2 variants.…”

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confidence: 61%

Genetics of suicide

2006

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The concept that genetic factors contribute to the complex trait of suicidal behaviour has stimulated much work aimed at identifying susceptibility genes. So far molecular genetic studies focused on the serotonergic pathway as the intent to die and the lethality of suicide acts were related to the serotonergic system. Two genes have so far emerged as being involved in the vulnerability for suicidality: first, the intronic polymorphisms (A218C or A779C) of the tryptophan hydroxylase 1 (TPH1) gene, which was suggested as a quantitative risk factor for suicidal behaviour; second, the insertion/deletion polymorphism of the serotonin transporter gene (5-HTTLPR), which does not seem to be involved in general suicidal behaviour, but in violent and repeated suicide attempts. The data have further shown that the MAOA gene, which is consistently associated with impulsive-aggressive personality traits, is not related to suicide but might induce violent methods in subjects with other suicide risk factors. Predominantly negative were the findings with any type of the serotonin receptors and inconsistent with catecholamine-synthesizing and -metabolizing enzymes or with the dopaminergic receptors. This paper reviews the status of current knowledge in this area, points to the weakness of the investigations and presents new approaches beyond the serotonergic system.

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confidence: 61%

Genetics of suicide

2006

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“…Another polymorphism influencing 5-HTT expression was identified by Ogilvie and colleagues 198 within intron 2 (STin2) and described as a 17bp VNTR polymorphism. It was reported that the STin2 polymorphism can play a role as a risk factor in MDD [198][199][200] and suicidal behaviour, 201,202 creating a synergistic effect with 5-HTTLPR. 203 The STin2 polymorphism seems to also affect antidepressant response, as reported by different authors, 85,175,182,191 and it was proposed that a STin2 10/12 genotype (where 10/12 indicates the number of repeats in the 2 alleles) may be associated with a poorer antidepressant effect, especially in Asian populations.…”

Section: Comtmentioning

confidence: 99%

Pharmacogenetics of antidepressant response

Porcelli

Drago

Fabbri

et al. 2011

J Psychiatry Neurosci

160

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87Personalized medicine -the adaptation of therapies based on an individual's genetic and molecular profile -is one of the most promising aspects of modern medicine. The identification of the relation between genotype and drug response, including both the therapeutic effect and side effect profile, is expected to deeply affect medical practice. In this paper, we review the current knowledge about the genes related to antidepressant treatment response and provide methodologic proposals for future studies. We have mainly focused on genes associated with pharmacodynamics, for which a list of promising genes has been identified despite some inconsistency across studies. We have also synthesized the main results for pharmacokinetic genes, although so far they seem less relevant than those for pharmaco dynamic genes. We discuss possible reasons for these inconsistent findings and propose new study designs.

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“…However, not all individuals with major depression commit suicide. Many studies have investigated factors associated with suicide in MDD patients, such as psychiatric comorbidities,67 genetic factors,89 melancholic features of MDD,1011 biomarkers,12 and environmental factors 13. Although some studies suggested that somatic symptoms are related to suicide,1415 gender differences regarding somatic symptoms and suicide are still poorly understood in MDD patients.…”

Section: Introductionmentioning

confidence: 99%

Gender Differences in Somatic Symptoms and Current Suicidal Risk in Outpatients with Major Depressive Disorder

Jeon

Woo

Kim

et al. 2016

Psychiatry Investig

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ObjectiveAlthough somatic symptoms are common complaints of patients with major depressive disorder (MDD), their associations with suicide are still unclear.MethodsA total of 811 MDD outpatients of aged between 18 to 64 years were enrolled nationwide in Korea with the suicidality module of the Mini-International Neuropsychiatric Interview (MINI) and the Depression and Somatic Symptom Scale (DSSS).ResultsOn stepwise regression analysis, current suicidality scores were most strongly associated with chest pain in men, and neck or shoulder pain in women. Severe chest pain was associated with higher current suicidality scores in men than in women, whereas severe neck or shoulder pain showed no significant differences between the genders. In conclusion, MDD patients of both sexes with suicidal ideation showed significantly more frequent and severe somatic symptoms than those without. Current suicidal risk was associated with chest pain in men, and neck or shoulder pain in women.ConclusionWe suggest that clinicians pay attention to patients' somatic symptoms in real world practice.

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STin2 Variant and Family History of Suicide as Significant Predictors of Suicide Completion in Major Depression

Cited by 54 publications

References 64 publications

Genetics of suicide

Genetics of suicide

Pharmacogenetics of antidepressant response

Gender Differences in Somatic Symptoms and Current Suicidal Risk in Outpatients with Major Depressive Disorder

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