STin2 VNTR polymorphism is associated with comorbid tobacco use and mood disorders

Castro, Márcia Regina Pizzo de; Nunes, Sandra Odebrecht Vargas; Guembarovski, Roberta Losi; Ariza, Carolina Batista; Oda, Julie Massayo Maeda; Vargas, Heber Odebrecht; Melo, Luiz Gustavo Piccoli de; Watanabe, Maria Angélica Ehara; Berk, Michael; Maes, Michaël

doi:10.1016/j.jad.2014.10.023

Cited by 13 publications

(2 citation statements)

References 75 publications

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“…They observed a greater likeliness mood disorders and suicidal attempts in anxious smokers than non-anxious smokers ( 166 ). Further the same group reported an association between comorbid mood and tobacco use disorder and Tin2.10/10, GSTM1, and GSTT1 genotypes and lowered paraoxonase 1 activity ( 167 , 168 ). Additionally, there are increased odds of BD in smokers who are homozygous for the PON1 QQ genotype and the risk for MDD was predicted by plasma PON1 expression, as well as interactions between genotype and smoking ( 169 ).…”

Section: Introductionmentioning

confidence: 85%

Inflammatory Markers in Substance Use and Mood Disorders: A Neuroimaging Perspective

et al. 2022

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Chronic exposure to addictive drugs in substance use disorders and stressors in mood disorders render the brain more vulnerable to inflammation. Inflammation in the brain, or neuroinflammation, is characterized by gliosis, microglial activation, and sustained release of cytokines, chemokines, and pro-inflammatory factors compromising the permeability of the blood-brain barrier. There is increased curiosity in understanding how substance misuse and/or repeated stress exposure affect inflammation and contribute to abnormal neuronal activity, altered neuroplasticity, and impaired cognitive control, which eventually promote compulsive drug-use behaviors and worsen mood disorders. This review will emphasize human imaging studies to explore the link between brain function and peripheral markers of inflammation in substance use disorders and mood disorders.

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Section: Introductionmentioning

confidence: 85%

Inflammatory Markers in Substance Use and Mood Disorders: A Neuroimaging Perspective

et al. 2022

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“…The allele featuring 12 repeats has the highest transcriptional activity [31]. This variant is reported to be associated with mood disorders [32].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Common Alleles of Some Stress Resilience Genes among Adolescents Born in Different Periods Relative to the Socioeconomic Crisis of the 1990s in Russia

Михайлова

Ivanoshchuk

Yushkevich

et al. 2022

CIMB

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Social stress is common among people and is considered one of the causes of the declining birth rate. Predisposition to stress and stress-induced disorders is largely determined genetically. We hypothesized that due to differences in stress resistance, carriers of different genetic variants of genes associated with stress resilience and stress-induced diseases may have dissimilar numbers of offspring under conditions of long-term social stress. To test this hypothesis, a comparative analysis of frequencies of seven common polymorphic regions [exon 3 variable number of tandem repeats (VNTR) of the DRD4 gene, rs4680 of COMT, STin2 VNTR and the 5-HTTLPR (rs774676466) insertion/deletion polymorphism of SLC6A4, rs4570625 of TPH2, rs6265 of BDNF, and rs258747 of NR3C1] was performed on standardized groups of randomly selected adolescents born before, during, and after severe socioeconomic deprivation (the crisis of the 1990s in Russia). There were significant differences in frequencies of “long” alleles of the DRD4 gene (p = 0.020, χ2 = 5.492) and rs4680 (p = 0.022, χ2 = 5.289) in the “crisis” group as compared to the combined “noncrisis” population. It is possible that the dopaminergic system had an impact on the successful adaptation of a person to social stress.

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Looking Beyond the 5-HTTLPR Polymorphism: Genetic and Epigenetic Layers of Regulation Affecting the Serotonin Transporter Gene Expression

2016

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Serotonin (5-HT) is a neurotransmitter that regulates fundamental aspects of brain development, physiology and behaviour. The serotonin transporter (5-HTT) is deputized to the reuptake of 5-HT from the intersynaptic space in the presynaptic neurons. 5-HTT governs duration and magnitude of 5-HT biological actions, acting as a master regulator of the fine-tuning of 5-HT signalling. Genetic variation at SLC6A4 gene locus, encoding 5-HTT, contributes to alteration in 5-HT reuptake. The 5-HTTLPR/rs25531/rs25532 polymorphisms located in the promoter region of SLC6A4 gene have been associated with stress-related psychopathology and functional brain phenotypes. Besides, further DNA variations in functional regulative elements located at 5' and 3' termini of the SLC6A4 gene influence transcriptional and post-transcriptional steps. Recently, epigenetic processes including SLC6A4 promoter methylation and transcript silencing by microRNA were shown to be involved in the aetiology of affective disorders. Furthermore, gene-environment interactions such as early life stress often encompass epigenetic changes, which can stably mark the genome in response to environmental stimuli potentially altering gene expression across lifespan. Therefore, it seems well established that functional variations in the SLC6A4 gene expression can no longer be ascribed to the modulating 5-HTTLPR promoter polymorphism but need to be integrated with the contribution arising from other interactive elements and epigenetic mechanisms. In this review, we discuss genetic and epigenetic layers of regulation affecting SLC6A4 gene expression. An overview of human and cellular studies investigating the impact of these regulatory processes on SLC6A4 gene expression is provided.

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STin2 VNTR polymorphism is associated with comorbid tobacco use and mood disorders

Cited by 13 publications

References 75 publications

Inflammatory Markers in Substance Use and Mood Disorders: A Neuroimaging Perspective

Inflammatory Markers in Substance Use and Mood Disorders: A Neuroimaging Perspective

Prevalence of Common Alleles of Some Stress Resilience Genes among Adolescents Born in Different Periods Relative to the Socioeconomic Crisis of the 1990s in Russia

Looking Beyond the 5-HTTLPR Polymorphism: Genetic and Epigenetic Layers of Regulation Affecting the Serotonin Transporter Gene Expression

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