Stinging Nettle: the Bad, the Good, the Unknown

Baumgardner, Dennis J

doi:10.17294/2330-0698.1216

Cited by 11 publications

(7 citation statements)

References 29 publications

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“…Urtica dioica (Urticaceae), commonly known as nettle is an herbaceous perennial species. Growing up to 1 m high, nettle produces erect and wiry stems that hold up its opposite, roughly textured, serrated leaves [1][2][3][4]. The plant is rich of chemical component and composition [5], which is why it has a long history of use as a food, medicine and against hair loss [1,2,6].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Capacity and Total Phenolic and Flavonoid Contents of Methanolic Extracts of Urtica dioica L. by Different Extraction Techniques

Bеgić

Horozić

Alibašić

et al. 2020

IRJPAC

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In this study, the efficacy of different extraction techniques (maceration, ultrasound-assisted and Soxhlet extraction) on the content of biologically active components in extracts from fresh and dried nettle leaves, and their antioxidant activity were analyzed. Methanol was used as the solvent. Total phenolic content and antioxidant capacity were determined by Folin-Ciocalteu, DPPH and FRAP methods, respectively. High content of total phenolic compounds and high antioxidant activity were recorded in extracts of dried nettle. Extracts obtained from fresh nettle samples showed significantly lower content of analyzed bioactive components and lower antioxidant activity. In the case of all extracts, Soxhlet extraction proved to be the most efficient, and maceration the least efficient extraction technique for isolation of bioactive components from nettle leaves.

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Section: Introductionmentioning

confidence: 99%

Antioxidant Capacity and Total Phenolic and Flavonoid Contents of Methanolic Extracts of Urtica dioica L. by Different Extraction Techniques

Bеgić

Horozić

Alibašić

et al. 2020

IRJPAC

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“…[1][2][3] However, it has been suggested that additional substances may be present. 4 Besides, U dioica has been widely reported to have various pharmacological activities such as immunomodulatory, anti-inflammatory, antioxidant or diuretic effects due to the numerous constituents identified in nettle herb (leaves and roots). 4 5 Physical contact with stinging nettle often results in a non-immunologic-induced contact urticarial or irritant dermatitis.…”

Section: Discussionmentioning

confidence: 99%

“…Chemical toxic substances found in the trichomes include histamine, acetylcholine and 5‐hydroxytryptamine (serotonin) 1–3. However, it has been suggested that additional substances may be present 4. Besides, U dioica has been widely reported to have various pharmacological activities such as immunomodulatory, anti‐inflammatory, antioxidant or diuretic effects due to the numerous constituents identified in nettle herb (leaves and roots) 4 5…”

Section: Discussionmentioning

confidence: 99%

Neurological signs following suspected exposure to stinging nettles in two dogs

Puig¹,

Griffin

Montoliu³

2019

Vet Record Case Reports

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Two gun dogs presented with a combination of neuromuscular and autonomic signs following suspected exposure to stinging nettles (Urtica dioica) in the UK. Both dogs developed first clinical signs on the same day and had been working in the same area where the presence of stinging nettles had been reported. Clinical signs included urticaria, tachypnoea, hypersalivation, bilateral miosis, ambulatory tetraparesis, muscle fasciculations and myokymia and generalised decreased hyporeflexia. Complete blood count and acetylcholinesterase activity were within normal limits apart from the elevated creatine kinase levels. One dog had three toxic episodes over a period of three weeks and the second case had a single toxic insult. Both dogs made a complete recovery after supportive care including intravenous fluid therapy, antihistamines, proton pump inhibitors, analgesics, antibiotics and steroidal eye-drops. There was no report of any permanent clinical signs as a result of the exposure.

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“…11 Inspired by a memorable patient encounter and the integrative medicine theme of the preceding issue of JPCRR, the review article on stinging nettle (p. 48) illustrates a natural product that can cause both harm and potential benefit. 16 Botulinum toxin is another obvious example of a naturally produced substance with effects both bad and good. 17 As with recent history regarding botulinum toxin, well-designed translational studies and clinical trials are needed to elucidate the potential therapeutic uses of stinging nettle extracts.…”

mentioning

confidence: 99%